Hesperadin

ChemicalBook > CAS DataBase List > Hesperadin

Product Name: Hesperadin
CAS No.: 422513-13-1
Chemical Name: Hesperadin
Synonyms: CS-408;Hesperadin;Hesperadine;Hesperadin, >=98%;Hesperadin USP/EP/BP;Hesperadin hydrochloride;Hesperadin (This product is unavailable in the U.S.);Hesperadin Hesperadine;(Z)-N-(2-Oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulf;(Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide
CBNumber: CB12537545
Molecular Formula: C29H32N4O3S
Formula Weight: 516.65
MOL File: 422513-13-1.mol

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Hesperadin Property

Melting point:: 228 °C
Density: 1.326
storage temp.: Refrigerator
solubility: DMSO, Methanol
form: Solid
pka: 9.14±0.20(Predicted)
color: Yellow
CAS DataBase Reference: 422513-13-1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 375680
Product name: Hesperadin - CAS 422513-13-1 - Calbiochem
Purity: Hesperadin primarily used in Inhibition.
Packaging: 5mg
Price: $280
Updated: 2024/03/01

Cayman Chemical

Product number: 24199
Product name: Hesperadin
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 24199
Product name: Hesperadin
Purity: ≥98%
Packaging: 5mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 24199
Product name: Hesperadin
Purity: ≥98%
Packaging: 10mg
Price: $310
Updated: 2024/03/01

Cayman Chemical

Product number: 24199
Product name: Hesperadin
Purity: ≥98%
Packaging: 25mg
Price: $711
Updated: 2024/03/01

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Hesperadin Chemical Properties,Usage,Production

Description

Hesperadin is a multi-kinase inhibitor. It inhibits human Aurora kinase B (IC₅₀ = 250 nM) and its T. brucei homolog Aurora kinase-1 (IC₅₀ = 40 nM) in in vitro kinase assays. Hesperadin (1 μM) inhibits AMPK, LCK, MKK1, MAPKAP-K1, CHK1, and PHK in a panel of 25 kinases. It also inhibits MEKK2 in ATPase and transphosphorylation assays with IC₅₀s of 60 and 34 nM, respectively. Hesperadin (50-100 nM) induces polyploidy and defects in cytokinesis and spindle assembly as well as inhibits proliferation of HeLa cells and overrides mitotic arrest induced by paclitaxel or monastrol . Hesperadin also induces toxicity in HepG2 cells with a toxic concentration (TC₅₀) value of less than 0.2 μM. It inhibits replication of clinical isolates of influenza A and B viruses with EC₅₀s ranging from 0.22 to 2.21 μM in a plaque formation assay. Hesperadin inhibits the growth of T. brucei, L. major promastigotes and amastigotes, and P. falciparum with EC₅₀ values ranging from 0.01 to 2.37 μM, but has less activity against T. cruzi (EC₅₀ = 39 μM).

Uses

Hesperadin phosphorylates human mitotic protein complexes that control physiological changes within the cell to allow for proper and successful chromosome segregation. It also targets aurora kinases in cancer treatment, affecting the chromosomes’ regulation during mitosis.

Definition

ChEBI: An oxindole that is indolin-2-one which is substituted at position 5 by an (ethylsulfonyl)nitrilo group and at position 2 by a methylidene group, which is itself substituted by a phenyl group and a [4-(piperidin-1-ylmethyl)phenyl]amino group. An Aurora B k nase inhibitor, it is used to inhibit chromosome alignment and segregation.

References

[1]jetton n1, rothberg kg, hubbard jg, wise j, li y, ball hl, ruben l. the cell cycle as a therapeutic target against trypanosoma brucei: hesperadin inhibits aurora kinase-1 and blocks mitotic progression in bloodstream forms. mol microbiol. 2009 apr;72(2):442-58. doi: 10.1111/j.1365-2958.2009.06657.x. epub 2009 mar 6.
[2]hauf s1, cole rw, laterra s, zimmer c, schnapp g, walter r, heckel a, van meel j, rieder cl, peters jm. the small molecule hesperadin reveals a role for aurora b in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. j cell biol. 2003 apr 28;161(2):281-94. epub 2003 apr 21.

Hesperadin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Hesperadin manufacturers

Career Henan Chemical Co

Product: Hesperadin 422513-13-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

422513-13-1, HesperadinRelated Search:

ZM 447439 MK-5108 (VX-689) Aurora A Inhibitor I MG-132 MLN8054 Barasertib (AZD1152-HQPA)

(Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide

Hesperadin Hesperadine

N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]ethanesulfonamide Hesperadin

Hesperadin, >=98%

Hesperadin

Hesperadin hydrochloride

N-[(3Z)-2-Oxo-3-[phenyl-[4-(piperidin-1-ylMethyl)anilino]Methylidene]-1H-indol-5-yl]ethanesulfonaMide

Hesperadine

N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]ethanesulfonamide

(Z)-N-(2-Oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulf

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Hesperadin (This product is unavailable in the U.S.)

CS-408

N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-ethanesulfonamide hydrochloride

Ethanesulfonamide, N-[2,3-dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-

Hesperadin USP/EP/BP

422513-13-1

Inhibitor

Inhibitors