(L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID

Product Name: (L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID
CAS No.: 28697-11-2
Chemical Name: (L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID
Synonyms: Z-HomoPro-OH;(S)-1-N-CBZ-PIPECOLINIC ACID;Z-D-PIP-OH;Z-D-PIPECOLIC ACID;Z-D-PIPECOLINIC ACID;Cbz-L-Pipecolic acid;N-Cbz-L-pipecolic acid;(L)-N-CBZ-PIPECOLIC ACID;(-)-N-CBZ-L-PIPECOLINIC ACID;N-Cbz-S-2-Piperidinecarboxylic aci
CBNumber: CB1254583
Molecular Formula: C14H17NO4
Formula Weight: 263.29
MOL File: 28697-11-2.mol

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(L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID Property

Melting point:: 111-115 °C(lit.)
Boiling point:: 443.9±45.0 °C(Predicted)
Density: 1.265
storage temp.: 2-8°C
pka: 4.01±0.20(Predicted)
Appearance: White to off-white Solid
optical activity: [α]22/D 59°, c = 2 in acetic acid
CAS DataBase Reference: 28697-11-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-38-37-36
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 499587
Product name: (S)-(?)-1-Cbz-2-piperidinecarboxylic acid
Purity: 97%
Packaging: 5g
Price: $69.5
Updated: 2023/01/07

TRC

Product number: B194195
Product name: (S)-1-((Benzyloxy)carbonyl)piperidine-2-carboxylicAcid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B194195
Product name: (S)-1-((Benzyloxy)carbonyl)piperidine-2-carboxylicAcid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: W5133
Product name: (S)-1-N-Cbz-Pipecolinicacid
Packaging: 5g
Price: $54
Updated: 2021/12/16

Chem-Impex

Product number: 16258
Product name: Z-L-homoproline,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5G
Price: $46.37
Updated: 2021/12/16

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(L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Synthesis

60369-19-9

28697-11-2

Method B: Synthesis of (S)-piperidine-1,2-dicarboxylic acid 1-benzyl ester 1. To a stirred mixed solution of (S)-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (8.0 g, 28.8 mmol) in MeOH (75 mL) and water (38 mL) at 0 °C was slowly added powdered KOH (1.78 g, 31.7 mmol). 2. The reaction mixture was stirred at room temperature for 16 hours. 3. Upon completion of the reaction, MeOH was removed under vacuum. 4. The residue was diluted with water and washed with DCM. 5. The aqueous layer was acidified with 1.0 M HCl to pH < 7 and subsequently extracted three times with ethyl acetate. 6. The organic extracts were combined, dried with anhydrous Na2SO4, filtered and concentrated in vacuum to afford (L)-N-CBZ-piperidinecarboxylic acid as a light yellow oil (7.6 g, 100% yield). Product Characterization: 1H NMR (400 MHz, CD3OD) δ 1.36-1.61 (2H, m), 1.70-1.85 (3H, m), 2.28-2.40 (1H, m), 3.05-3.26 (1H, m), 4.06-4.14 (1H, m), 4.89-5.26 (4H, m), 7.37-7.48 (5H, m ); 13C NMR (100 MHz, CD3OD) δ 20.5,20.6 (CH2), 24.6,24.7 (CH2), 26.6 (CH2), 41.8,41.9 (CH2), 54.5,54.7 (CH), 67.2,67.3 (CH2), 127.6 (CH), 127.9 (CH), 128.4 (CH), 136.9 (C), 173.4 (CO). Note: Method C does not provide detailed information.

References

[1] Patent: US2002/61853, 2002, A1
[2] Patent: US2003/96737, 2003, A1

(L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID Suppliers

China 86 Europe 2 Germany 3 India 1 Switzerland 1 United Kingdom 6 United States 23 Global 122

J & K SCIENTIFIC LTD.

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China Langchem Inc.

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View Lastest Price from (L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID 28697-11-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-()-1-Cbz-2-piperidinecarboxylic acid 28697-11-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: (L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID 28697-11-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-30

28697-11-2, (L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACIDRelated Search:

Z-HomoSer-OH Z-HYP(TBU)-OH Z-Hyp(tBu)-OH.DCHA 1-CBZ-2-PIPERIDINECARBOXYLIC ACID L(-)-Pipecolinic acid 1-CBZ-2-PIPERIDINECARBOXYLIC ACID D(+)-Pipecolinic acid (D)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID METHYL (2S,5R)-1-CBZ-5-HYDROXY-6-METHOXYPIPECOLINATE (L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID CBZ-(2S, 4R)-4-HYDROXY-PIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER (3S,4AS,8AS)-2-CARBOBENZYLOXY-DECAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID CIS-4-HYDROXY-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER

(L)-N-CBZ-PIPECOLIC ACID

(L)-N-(BENZYLOXYCARBONYL)PIPECOLIC ACID

Z-D-PIPECOLIC ACID

Z-D-PIPECOLINIC ACID

Z-D-PIP-OH

PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER

(-)-N-CBZ-L-PIPECOLINIC ACID

N-BENZYLOXYCARBONYL-(S)-(-)-PIPECOLINIC ACID

(S)-1-N-CBZ-PIPECOLINIC ACID

(S)-(-)-1-(CARBOBENZYLOXY)-2-PIPERIDINECARBOXYLIC ACID

(S)-1-(BENZYLOXYCARBONYL)PIPERIDINE-2-CARBOXYLIC ACID

(S)-(-)-N-BENZYLOXYCARBONYL-PIPECOLINIC ACID

(S)-N-CARBOBENZYLOXY-2-PIPERIDINECARBOXYLIC ACID

(S)-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER

(S)-(-)-1-(carbobenzyloxy)-2-piperidine-carboxyli

(S)-(-)-1-Cbz-2-piperidinecarboxylic acid, 97%

(2S)-1-(Carbobenzyloxy)-2-piperidinecarboxylic acid

(2S)-1-[(Benzyloxy)carbonyl]hexahydro-2-pyridinecarboxylic acid

(S)-(-)-1-Cbz-piperidine-2-carboxylic acid

N-Benzyloxycarbonyl-(S)-piperidine-2-carboxylic acid

N-Cbz-S-2-Piperidinecarboxylic acid

(S)-(-)-1-Cbz-2-piperidinecarboxylic acid 97%

1,2-Piperidinedicarboxylic acid, 1-(phenylmethyl) ester, (2S)-

(S)-1-(Benzyloxycarbonyl)-2-piperidine-carboxylic Acid

(2S)-1-benzyloxycarbonylpiperidine-2-carboxylic acid

(2S)-1-phenylmethoxycarbonylpiperidine-2-carboxylic acid

N-Cbz-L-pipecolic acid

Z-HomoPro-OH

N-Cbz-S-2-Piperidinecarboxylic aci

Cbz-L-Pipecolic acid

(<i>S</i>)-(?)-1-Cbz-2-piperidinecarboxylic acid

(S)-(-)-1-(carbobenzyloxy)-2-piperidine-carboxylic

(S)-(-)-1-Cbz-2-piperidinecarboxylic acid

28697-11-2

CARBOXYLIC ACID

Piperidines

Heterocyclic Building Blocks

Chiral Building Blocks

Asymmetric Synthesis

chiral

Chiral Building Blocks

Heterocyclic Building Blocks

Piperidines