1-CBZ-2-PIPERIDINECARBOXYLIC ACID
- Product Name
- 1-CBZ-2-PIPERIDINECARBOXYLIC ACID
- CAS No.
- 28697-07-6
- Chemical Name
- 1-CBZ-2-PIPERIDINECARBOXYLIC ACID
- Synonyms
- Z-PIP-OH;Z-DL-Pip-OH;Z-PIPECOLIC ACID;Z-PIPECOLINIC ACID;1-Cbz-pipecolic Acid;1-Carbobenzoxypipecolic Acid;1-CBZ-2-PIPERIDINECARBOXYLIC ACID;1-Benzyloxycarbonylpipecolic Acid;1-CBZ-PIPERIDINE-2-CARBOXYLIC ACID;1-N-Cbz-piperidine-2-carboxylic acid
- CBNumber
- CB8239288
- Molecular Formula
- C14H17NO4
- Formula Weight
- 263.29
- MOL File
- 28697-07-6.mol
1-CBZ-2-PIPERIDINECARBOXYLIC ACID Property
- Melting point:
- 110 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 443.9±45.0 °C(Predicted)
- Density
- 1.265±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder to crystal
- pka
- 4.01±0.20(Predicted)
- color
- White to Almost white
Safety
- Risk Statements
- 20/21/22
- Safety Statements
- 24/25-36/37/38-29/56-41-45-3/7/9
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C3382
- Product name
- 1-Carbobenzoxy-2-piperidinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- C3382
- Product name
- 1-Carbobenzoxy-2-piperidinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $153
- Updated
- 2025/07/31
- Product number
- FB140505
- Product name
- 1-((Benzyloxy)carbonyl)piperidine-2-carboxylic acid
- Packaging
- 50g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 43504
- Product name
- 1-Carbobenzoxy-2-piperidinecarboxylicacid,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 5G
- Price
- $179.11
- Updated
- 2021/12/16
- Product number
- FB140505
- Product name
- 1-((Benzyloxy)carbonyl)piperidine-2-carboxylic acid
- Packaging
- 100g
- Price
- $289
- Updated
- 2021/12/16
1-CBZ-2-PIPERIDINECARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
1,?2-?Piperidinedicarboxyl?ic Acid 1-?(Phenylmethyl) Ester is used to prepare disubstituted azetidinones as selective inhibitors of cysteine protease cathepsin K. It is also used to synthesize 2-?[(R)?-?2-?methylpyrrolidin-?2-?yl]?-?1H-?benzimidazole-?4-?carboxamide (ABT-?888) as the Poly(ADP-?ribose) Polymerase (PARP) inhibitor for the treatment of cancer.
Synthesis
501-53-1
4043-87-2
28697-07-6
10 g of 2-piperidinecarboxylic acid was added to a 250 mL four-neck flask, dissolved in 80 g of 10% aqueous sodium hydroxide solution and stirred until completely dissolved. Subsequently, a mixture of 15.7 g of benzyl chloroformate and 25 g of 10% aqueous sodium hydroxide solution was added dropwise. The reaction was stirred continuously at room temperature for 12 hours. Upon completion of the reaction, the reaction mixture was diluted with 100 mL of ether, followed by adjusting the pH of the aqueous layer with dilute hydrochloric acid to weakly acidic. The aqueous layer was extracted three times with ether and all organic layers were combined. The organic layer was dried with anhydrous magnesium sulfate, filtered, and the organic solvent was concentrated under reduced pressure to give 19.6 g of 1-N-benzyloxycarbonyl-2-piperidinecarboxylic acid in 96.1% yield.
References
[1] Patent: US6337423, 2002, B1. Location in patent: Example 10
[2] Patent: CN105418489, 2016, A. Location in patent: Paragraph 0010; 0015
[3] Journal of Organic Chemistry, 1993, vol. 58, # 4, p. 860 - 866
[4] Journal of Chemical Research, 2008, # 8, p. 468 - 472
[5] Patent: WO2010/21797, 2010, A1. Location in patent: Page/Page column 106
1-CBZ-2-PIPERIDINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-CBZ-2-PIPERIDINECARBOXYLIC ACID manufacturers
- Product
- 1-CBZ-2-PIPERIDINECARBOXYLIC ACID 28697-07-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08