ChemicalBook > CAS DataBase List > MPEG5-NHS

MPEG5-NHS

Product Name
MPEG5-NHS
CAS No.
1449390-12-8
Chemical Name
MPEG5-NHS
Synonyms
MPEG5-NHS;mPEG5-SPA;mPEG6-NHS;m-PEG6-NHS ester;Methyl-PEG5-NHS ester;mPEG5-CH2CH2COONHS Ester;4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;mPEG5-CH2CH2COONHS/4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber
CB12546945
Molecular Formula
C18H31NO10
Formula Weight
421.44
MOL File
1449390-12-8.mol
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MPEG5-NHS Property

Boiling point:
502.6±60.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO, DCM, DMF
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
P999900
Product name
mPEG5-CH2CH2COONHSEster
Packaging
500mg
Price
$310
Updated
2021/12/16
ChemPep
Product number
281303
Product name
mPEG5-NHS
Packaging
1g
Price
$306
Updated
2021/12/16
BroadPharm
Product number
BP-22086
Product name
m-PEG6-NHSester
Purity
98%
Packaging
500mg
Price
$350
Updated
2021/12/16
chempep
Product number
281307
Product name
mPEG6-NHS
Purity
>=95%
Packaging
500mg
Price
$360
Updated
2021/12/16
AK Scientific
Product number
0500AP
Product name
mPEG5-NHS
Packaging
1g
Price
$451
Updated
2021/12/16
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MPEG5-NHS Chemical Properties,Usage,Production

Description

m-PEG6-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.

Biological Activity

MPEG5-NHS is a non-cleavable 6-unit PEG-containing ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG/Alkyl/ether class, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Alkyl/ether

Non-cleavable

MPEG5-NHS Preparation Products And Raw materials

Raw materials

Preparation Products

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MPEG5-NHS Suppliers

China 48 India 1 United Kingdom 1 United States 5 Global 55
Daicel Chiral Technologies (China)CO.,LTD
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View Lastest Price from MPEG5-NHS manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
m-PEG6-NHS ester 1449390-12-8
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-27

1449390-12-8, MPEG5-NHSRelated Search:

m-PEG8-NHS ester MPEG4-NHS MPEG3-NHS MPEG11-NHS MPEG36-OH MPEG24-OH MPEG48-OH Pentaethylene glycol mono methyl ether tosylate MPEG8-NH-Mal MPEG6-Mal 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosanoic acid Mal-PEG3-alcohol 3,6,9,12,15,18-Hexaoxanonadecane-1-thiol 2,5-Dioxopyrrolidin-1-yl 3-methoxypropanoate MAl-PEG6-t-butyl ester Mal-PEG4-NHS ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) MPEG12-Mal

  • MPEG5-NHS
  • 4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
  • m-PEG6-NHS ester
  • mPEG5-CH2CH2COONHS Ester
  • mPEG6-NHS
  • Methyl-PEG5-NHS ester
  • mPEG5-SPA
  • mPEG5-CH2CH2COONHS/4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
  • 1449390-12-8
  • C18H31NO10
  • mPEG