MPEG5-NHS

ChemicalBook > CAS DataBase List > MPEG5-NHS

Product Name: MPEG5-NHS
CAS No.: 1449390-12-8
Chemical Name: MPEG5-NHS
Synonyms: MPEG5-NHS;mPEG5-SPA;mPEG6-NHS;m-PEG6-NHS ester;Methyl-PEG5-NHS ester;mPEG5-CH2CH2COONHS Ester;4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;mPEG5-CH2CH2COONHS/4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB12546945
Molecular Formula: C18H31NO10
Formula Weight: 421.44
MOL File: 1449390-12-8.mol

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MPEG5-NHS Property

Boiling point:: 502.6±60.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P999900
Product name: mPEG5-CH2CH2COONHSEster
Packaging: 500mg
Price: $310
Updated: 2021/12/16

BroadPharm

Product number: BP-22086
Product name: m-PEG6-NHSester
Purity: 98%
Packaging: 500mg
Price: $350
Updated: 2021/12/16

chempep

Product number: 281307
Product name: mPEG6-NHS
Purity: >=95%
Packaging: 500mg
Price: $360
Updated: 2021/12/16

AK Scientific

Product number: 0500AP
Product name: mPEG5-NHS
Packaging: 1g
Price: $451
Updated: 2021/12/16

chempep

Product number: 281307
Product name: mPEG6-NHS
Purity: >=95%
Packaging: 1g
Price: $540
Updated: 2021/12/16

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MPEG5-NHS Chemical Properties,Usage,Production

Description

m-PEG6-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.

Biological Activity

MPEG5-NHS is a non-cleavable 6-unit PEG-containing ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG/Alkyl/ether class, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Alkyl/ether

Non-cleavable

MPEG5-NHS Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MPEG5-NHS manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: m-PEG6-NHS ester 1449390-12-8
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-27

1449390-12-8, MPEG5-NHSRelated Search:

m-PEG8-NHS ester MPEG4-NHS MPEG3-NHS MPEG11-NHS MPEG36-OH MPEG24-OH MPEG48-OH Pentaethylene glycol mono methyl ether tosylate MPEG8-NH-Mal MPEG6-Mal 3,6,9,12,15,18,21,24,27-Nonaoxaoctacosanoic acid Mal-PEG3-alcohol 3,6,9,12,15,18-Hexaoxanonadecane-1-thiol 2,5-Dioxopyrrolidin-1-yl 3-methoxypropanoate MAl-PEG6-t-butyl ester Mal-PEG4-NHS ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) MPEG12-Mal

MPEG5-NHS

4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester

m-PEG6-NHS ester

mPEG5-CH2CH2COONHS Ester

mPEG6-NHS

Methyl-PEG5-NHS ester

mPEG5-SPA

mPEG5-CH2CH2COONHS/4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester

1449390-12-8

C18H31NO10

mPEG