4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine
- Product Name
- 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine
- CAS No.
- 916176-52-8
- Chemical Name
- 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine
- Synonyms
- 4-BroMo-5-chloro-7-azaindole;4-Bromo-5-chloro-1H-pyrrolo[2;4-BroMo-5-chloro-7-aza-1H-indole;4-BroMo-5-chloro-7-aza-2H-indole;4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine;1H-pyrrolo[2,3-b]pyridine, 4-broMo-5-chloro-
- CBNumber
- CB12554717
- Molecular Formula
- C7H4BrClN2
- Formula Weight
- 231.48
- MOL File
- 916176-52-8.mol
4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine Property
- Density
- 1.878
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.04±0.40(Predicted)
- Appearance
- Off-white to pink Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1548AQ
- Product name
- 4-BROMO-5-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
- Packaging
- 100mg
- Price
- $258.8
- Updated
- 2021/12/16
- Product number
- 1548AQ
- Product name
- 4-BROMO-5-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
- Packaging
- 1g
- Price
- $1143.2
- Updated
- 2021/12/16
- Product number
- A296012
- Product name
- 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $1250
- Updated
- 2021/12/16
- Product number
- CD11017227
- Product name
- 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1386
- Updated
- 2021/12/16
- Product number
- 916176528
- Product name
- 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 5g
- Price
- $1503.48
- Updated
- 2021/12/16
4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine Chemical Properties,Usage,Production
Uses
4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine can be used in drug synthesis and as a pharmaceutical intermediate in scientific research.
Synthesis
916176-51-7
916176-52-8
5-Chloro-1H-pyrrolo[2,3-b]pyridine-7-oxide (5.00 g, 29.66 mmol) was used as a raw material, which was dissolved with tetrabutylammonium bromide (Bu4Br, 19.12 g, 59.31 mmol) in N,N-dimethylformamide (DMF, 200 mL). Trifluoromethanesulfonic anhydride (Tf2O, 20.91 g, 74.20 mmol) was slowly added dropwise to the above solution at 0 °C. After the dropwise addition, the reaction mixture was stirred at room temperature for 2 hours. Subsequently, the reaction solution was poured into water (500 mL), and the pH of the mixture was adjusted to 8-9 with saturated aqueous sodium bicarbonate (NaHCO3). The precipitate was collected by filtration, and the filter cake was washed with water (50 mL x 3) and dried under vacuum at 60 °C overnight to afford 4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine as an off-white solid (5.83 g, yield 84.9%). Mass spectrum (ESI, positive ion mode) m/z: 231.0 [M + H]+; NMR hydrogen spectrum (400 MHz, DMSO-d6) δ (ppm): 12.24 (s, 1H), 8.30 (s, 1H), 7.68 (s, 1H), 6.45 (s, 1H).
References
[1] Patent: WO2018/169700, 2018, A1. Location in patent: Paragraph 00328; 00329
[2] Patent: US2010/81645, 2010, A1. Location in patent: Page/Page column 37
[3] Patent: WO2006/127587, 2006, A1. Location in patent: Page/Page column 87
4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine Suppliers
- Tel
- 8485655694
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- Country
- United States
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View Lastest Price from 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine manufacturers
- Product
- 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine 916176-52-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10