5-chloro-2,4-dihydroxybenzaldehyde

Product Name: 5-chloro-2,4-dihydroxybenzaldehyde
CAS No.: 131088-02-3
Chemical Name: 5-chloro-2,4-dihydroxybenzaldehyde
Synonyms: 5-chloro-2,4-dihydroxybenzaldehyde;2,4 -dihydroxy-5-chlorobenzaldehyde;Benzaldehyde, 5-chloro-2,4-dihydroxy-;5-Chloro-2,4-dihydroxybenzaldehyde，97%
CBNumber: CB12561249
Molecular Formula: C7H5ClO3
Formula Weight: 172.57
MOL File: 131088-02-3.mol

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5-chloro-2,4-dihydroxybenzaldehyde Property

Melting point:: 163-164 °C
Boiling point:: 332.8±22.0 °C(Predicted)
Density: 1.570±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 6.11±0.23(Predicted)
Appearance: White to pink Solid
InChI: InChI=1S/C7H5ClO3/c8-5-1-4(3-9)6(10)2-7(5)11/h1-3,10-11H
InChIKey: IPOSHVWRFQTHGK-UHFFFAOYSA-N
SMILES: C(=O)C1=CC(Cl)=C(O)C=C1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 5108CV
Product name: 5-Chloro-2,4-dihydroxybenzaldehyde
Packaging: 1g
Price: $107
Updated: 2021/12/16

Chemenu

Product number: CM248777
Product name: 5-Chloro-2,4-dihydroxybenzaldehyde
Purity: 95%
Packaging: 1g
Price: $343
Updated: 2021/12/16

Crysdot

Product number: CD12154585
Product name: 5-Chloro-2,4-dihydroxybenzaldehyde
Purity: 95+%
Packaging: 1g
Price: $363
Updated: 2021/12/16

Alichem

Product number: 131088023
Product name: 5-Chloro-2,4-dihydroxybenzaldehyde
Packaging: 1g
Price: $367
Updated: 2021/12/16

JR MediChem

Product number: 60149
Product name: 5-chloro-2,4-dihydroxybenzaldehyde
Purity: >95%
Packaging: 5g
Price: $880
Updated: 2021/12/16

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5-chloro-2,4-dihydroxybenzaldehyde Chemical Properties,Usage,Production

Synthesis

95-01-2

131088-02-3

General procedure for the synthesis of 5-chloro-2,4-dihydroxybenzaldehyde from 2,4-dihydroxybenzaldehyde: Sulfonyl chloride (14 mL, 171.2 mmol) was added slowly and dropwise to a solution of 2,4-dihydroxybenzaldehyde (20 g, 144.92 mmol) in ether (500 mL) at 0 °C and under argon protection. After the dropwise addition was completed, the reaction mixture was warmed to room temperature and stirring was continued for 30 minutes. Subsequently, the reaction mixture was poured into ice water to separate the organic layer. The organic layer was washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=90:10) to afford 5-chloro-2,4-dihydroxybenzaldehyde as an off-white solid (6.7 g, 26% yield, 97% purity by LC/MS). eSI-MS, m/z 170.9 [M-H]? ; elemental analysis consistent with C7H5ClO3; 1H NMR (DMSO-d6, 400 MHz): δ 11.39 (1H, s), 10.87 (1H, s), 9.98 (1H, s), 7.0 (1H, s), 6.58 (1H, s).

References

[1] Chemical Biology and Drug Design, 2015, vol. 86, # 5, p. 1030 - 1035
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 19, p. 3505 - 3508
[3] Chemical Communications, 2008, # 10, p. 1217 - 1219
[4] Heterocycles, 1997, vol. 45, # 7, p. 1345 - 1361
[5] Journal of the American Chemical Society, 2010, vol. 132, # 26, p. 8828 - 8830

5-chloro-2,4-dihydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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5-chloro-2,4-dihydroxybenzaldehyde Suppliers

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View Lastest Price from 5-chloro-2,4-dihydroxybenzaldehyde manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-chloro-2,4-dihydroxybenzaldehyde 131088-02-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-08

131088-02-3, 5-chloro-2,4-dihydroxybenzaldehydeRelated Search:

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5-Chloro-2,4-dihydroxybenzaldehyde，97%

131088-02-3