Asiaticoside

Product Name: Asiaticoside
CAS No.: 16830-15-2
Chemical Name: Asiaticoside
Synonyms: Asiaticosides;asiaticosid;MADECASSOL;dermatologico;blastoestimulina;2-alpha,3-beta,23-trihydroxy-urs-12-en-28-oicacio-6-deoxy-alpha-l-mannopy;Ba-2742;CENTELASE;MADECASOL;Meal snow
CBNumber: CB7109339
Molecular Formula: C48H78O19
Formula Weight: 959.12
MOL File: 16830-15-2.mol

More

Less

Asiaticoside Property

Melting point:: 235-238°C
alpha: D20 -14° (alc)
Boiling point:: 1017.5±65.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
vapor pressure: 0.001Pa at 160℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly)
pka: 12.50±0.70(Predicted)
form: Solid
color: Crystals
Water Solubility: 99mg/L
InChIKey: WYQVAPGDARQUBT-KRQXBQLUNA-N
LogP: 0.44 at 22℃
CAS DataBase Reference: 16830-15-2(CAS DataBase Reference)

More

Less

Safety

Safety Statements: 24/25
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
RTECS: YU9625000
F: 1-10
HS Code: 29389090

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 43191
Product name: Asiaticoside
Purity: analytical standard
Packaging: 5mg
Price: $165
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1043331
Product name: Asiaticoside
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 30mg
Price: $500
Updated: 2024/03/01

Sigma-Aldrich

Product number: 04560590
Product name: Asiaticoside
Purity: primary pharmaceutical reference standard
Packaging: 10mg
Price: $499
Updated: 2024/03/01

Sigma-Aldrich

Product number: 43191
Product name: Asiaticoside
Purity: analytical standard
Packaging: 1mg
Price: $33.7
Updated: 2022/05/15

Cayman Chemical

Product number: 11819
Product name: Asiaticoside
Purity: ≥95%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

More

Less

Asiaticoside Chemical Properties,Usage,Production

Description

Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat a variety of ailments including dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. In various wound healing models, topical application (0.2-0.4%), injection (1 mg), or ingestion (1 mg/kg) of asiaticoside has been shown to increase hydroxyproline content, improve tensile strength, increase collagen synthesis and remodeling of the collagen matrix, promote epithelialization, stimulate glycosaminoglycan synthesis, and elevate antioxidant levels.

Chemical Properties

White powder

Uses

wound healing, anxiolytic

Uses

Asiatic Acid is a terpenoid saponin component isolated from Centella asiatica with antioxidant and anti-inflammatory activities. Asiaticoside has been shown to possess strong wound-healing properties and reduces scar formation.

Definition

ChEBI: Asiaticoside is a triterpenoid saponin.

Flammability and Explosibility

Not classified

Biological Activity

Asiaticoside, a triterpenoid compound from Centella asiatica, has been shown to have anti-inflammatory, anti-renal fibrosis and tissue repair promoting effects. Asiaticoside has been shown through ex vivo and in vivo studies to reduce blood urea nitrogen (BUN) and serum creatinine (Scr) levels in a renal ischemia-reperfusion injury (IRI) model^[1]. Meanwhile, Asiaticoside decreased the secretion of IL-6, IL-1β, and TNF-α, but increased the secretion of IL-10 using a dose-dependent manner. Treatment of Raw264.7 cells with lipopolysaccharide (LPS) induced an inflammatory response, but the LPS-induced effect was attenuated by the administration of asiaticoside. In addition, asiaticoside significantly inhibits LPS-induced expression of inducible nitric oxide synthase (iNOS) and promotes expression of the polarisation marker protein arginase 1. It is also a potential candidate for use as a dental wound healing agent with a maximum tolerated concentration of 0.25 mg/ml, and its mechanism of action may be related to increased Col1A1 gene expression ^[2].

Safety Profile

Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits acrid smoke and fumes. Promoteshealing of wounds.

storage

+4°C

References

[1] XINGYING ZHAO, JINGWEN ZHOU*; Elucidation of the Biosynthesis of Asiaticoside and Its Reconstitution in Yeast[J]. ACS Sustainable Chemistry & Engineering, 2024, 12 10: 4028-4040. DOI:10.1021/acssuschemeng.3c07046.
[2] W. H. SURIYAH. In Vitro Wound Healing Effect of Asiaticoside Extracted from Centella asiatica (‘Pegaga’) on Human Gingival Fibroblast Cell Line[J]. Materials Science Forum, 2021, 72 1: 224-229. DOI:10.4028/www.scientific.net/MSF.1025.224.

Asiaticoside Preparation Products And Raw materials

Raw materials

PETROLEUM ETHER

Preparation Products

More

Less

Asiaticoside Suppliers

Belgium 1 Brazil 1 Canada 1 China 416 Czech Republic 1 Egypt 1 Europe 2 France 2 Germany 5 India 8 Italy 1 Japan 1 Poland 1 Switzerland 2 United Kingdom 7 United States 46 Global 496

Shaanxi Haochen Biological Technology Co., Ltd.

Tel: 15389083437
Email: 18991341291@qq.com
Country: China
ProdList: 1
Advantage: 58

Guilin Benefittw Biotechnology Co.,LTD.

Tel: 0773-0773-8280552 18978691595
Fax: 0773-8280552
Email: 935960@qq.com
Country: China
ProdList: 40
Advantage: 58

Tongchuan Boliante Chemical Co. LTD

Tel: 17719597442
Email: 642232259@qq.com
Country: China
ProdList: 92
Advantage: 58

Xi'AnTongZeBiotechCo.,Ltd

Tel: +86-18591971926 +86-18591971926
Email: 3516471159@qq.com
Country: China
ProdList: 155
Advantage: 58

Hangzhou Linran Biotechnology Co. LTD

Tel: 0571-18067987-92 18067987892
Fax: 0571-88772395
Email: 2543558860@qq.com
Country: China
ProdList: 138
Advantage: 58

Nanjing bingcheng Biotechnology Co., Ltd.

Tel: 18805194892
Email: 2727751293@qq.com
Country: China
ProdList: 157
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

More

Less

View Lastest Price from Asiaticoside manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Asiaticoside 16830-15-2
Price: US $80.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/Week
Release date: 2024-04-23

Sinoway Industrial co., ltd.

Product: Asiaticoside 16830-15-2
Price: US $0.00-0.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 90% up
Supply Ability: 20 tons
Release date: 2024-06-27

Hovane Phytochemicals Co., Ltd

Product: Asiaticoside 16830-15-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 90%HPLC
Supply Ability: 1 ton
Release date: 2024-11-07

16830-15-2, AsiaticosideRelated Search:

Asiaticoside Kresoxim-methyl Centella asiatica extract Methyl acetate Bensulfuron methyl Thiophanate-methyl METSULFURON METHYL Methyl salicylate Methylparaben Rotundine Sophoricoside Ursolic acid Asiaticoside B Methyl Centella asiatica whole plant Methyl bromide GLYCEROL MONOISOSTEARATE Hydroxy asiaticoside Madecassol

2-alpha,3-beta,23-trihydroxy-urs-12-en-28-oicacio-6-deoxy-alpha-l-mannopy

asiaticosid

blastoestimulina

dermatologico

ranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-6)-o-beta-d-glucopyranosylester

CENTELASE

ASIATICOSIDE

MADECASOL

MADECASSOL

[6-[[3,4-Dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyl-oxan-2-yl)oxy-oxan-2-yl]oxymethyl]-3,4,5-trihydroxy-oxan-2-yl] (1S,2R,4aS,6aS,6bR,9S,10R,11R,12aS,14bR)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate

Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-.alpha.-L-mannopyranosyl-(1?4)-O-.beta.-D-glucopyranosyl-(1?6)-.beta.-D-glucopyranosyl ester, (2.alpha.,3.beta.,4.alpha.)-

ASIATICOSIDE(P)

Gotu Kola (Centella Asiatica) (40%Asiatisides)

Urs-12-en-28-oic acid,2,3,23-trihydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranos

yl-(1→6)- β-D-glucopyranosyl ester, (2α,3β,4α)-

O-6-Deoxy-a-L-mannopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->6)-b-D-glucopyranosyl (2a,3b,4a)-2,3,23-trihydroxyurs-12-en-28-oate

O-6-Deoxy-a-L-mannopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->6)-b-D-glucopyranosyl ester, (2a,3b,4a)-

(4R)-2α,3β,23-Trihydroxyurs-12-en-28-oic acid [6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl] ester

2α,3β,23-Trihydroxyurs-12-en-28-oic acid 6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester

Ba-2742

Asiaticosides

Centella Asiatica(40%Asiatisides)

ASIATICOSIDE hplc

ASIATICOSIDE WITH HPLC

Asiaticoside,Madecassol

Asiaticoside Gotu Kola Extract

(1S,2R,4aS,6aS,6bR,9S,10R,11R,12aS,14bR)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate

BlastostiMulina

EMdecassol

Marticassol

Asiaticoside (30 mg)

Asiaticoside, froM Centella asiatica

Asiaticoside 16830-15-2

Centella asiatica extractTriterpenoid saponins

Total Triterpenes of centella asiatica extract

Asiaticoside(Single)

(1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid [(2S,3R,4S

Centella asiatica Extract Asiaticoside powder

Meal snow

Asiaticoside, 98%, from Centella asiatica (L.) Urb.

Asiaticoside, >=98%

Asiaticosides 10%-80%

Asiaticoside CRS

BRN0078195

CCRIS8995

NSC166062

Asiaticoside,90%

Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α)-

Asiaticoside USP/EP/BP

Centella asiatica powder

Asiaticoside/Centella asiatica

Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α)-

asiaticcoside

Asiaticoside (6CI)

(1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate

Centella Total Glucosides, CTG

Asiaticoside-RM

16830-15-2