Madecassic acid
- Product Name
- Madecassic acid
- CAS No.
- 18449-41-7
- Chemical Name
- Madecassic acid
- Synonyms
- Madecasoside;MADECASSIC ACID;MADECASSIC ACID(P);Hydroxyasiatic acid;Hydroxy asiaticoside;6-Hydroxyasiatic acid;Madecassic Acid (97%);Brahmic acid 18449-41-7;6BETA-HYDROXYASIATIC ACID;Hydroxycentella glycoside
- CBNumber
- CB7280283
- Molecular Formula
- C30H48O6
- Formula Weight
- 504.71
- MOL File
- 18449-41-7.mol
Madecassic acid Property
- Melting point:
- 270°C (dec.)
- Boiling point:
- 641.7±55.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Sparingly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 4.63±0.70(Predicted)
- color
- White to Pale Red
- InChI
- InChI=1/C30H48O6/c1-16-9-10-30(25(35)36)12-11-28(5)18(22(30)17(16)2)7-8-21-26(3)13-20(33)24(34)27(4,15-31)23(26)19(32)14-29(21,28)6/h7,16-17,19-24,31-34H,8-15H2,1-6H3,(H,35,36)/t16-,17+,19-,20-,21-,22+,23-,24+,26-,27+,28-,29-,30+/s3
- InChIKey
- PRAUVHZJPXOEIF-MRQYELSVNA-N
- SMILES
- C[C@]12C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]1([H])[C@H](O)C[C@]1([C@@]3(CC[C@]4(CC[C@@H](C)[C@H](C)[C@@]4([H])C3=CC[C@]21[H])C(=O)O)C)C |&1:1,3,5,7,11,13,16,17,20,23,25,27,32,r|
- LogP
- 4.321 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 11854
- Product name
- Madecassic Acid
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 11854
- Product name
- Madecassic Acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 11854
- Product name
- Madecassic Acid
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 11854
- Product name
- Madecassic Acid
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- M107500
- Product name
- MadecassicAcid(97%)
- Packaging
- 250mg
- Price
- $265
- Updated
- 2021/12/16
Madecassic acid Chemical Properties,Usage,Production
Description
Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; ), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 μg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; ). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.
Chemical Properties
White powder
Uses
wound healing
Uses
Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Uses
Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Definition
ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).
Madecassic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Madecassic acid manufacturers
- Product
- Madecassic acid 18449-41-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥98%HPLC
- Supply Ability
- 20tons
- Release date
- 2024-01-05
- Product
- Madecassic acid 18449-41-7
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.912%
- Supply Ability
- 10ton
- Release date
- 2024-04-24
- Product
- Madecassic acid 18449-41-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- >95%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-09