Madecassic acid

Product Name: Madecassic acid
CAS No.: 18449-41-7
Chemical Name: Madecassic acid
Synonyms: Madecasoside;MADECASSIC ACID;MADECASSIC ACID(P);Madecassic acid-RM;Hydroxyasiatic acid;Hydroxy asiaticoside;6-Hydroxyasiatic acid;Madecassic Acid (97%);Brahmic acid 18449-41-7;6BETA-HYDROXYASIATIC ACID
CBNumber: CB7280283
Molecular Formula: C30H48O6
Formula Weight: 504.71
MOL File: 18449-41-7.mol

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Madecassic acid Property

Melting point:: 270°C (dec.)
Boiling point:: 641.7±55.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Sparingly), Methanol (Slightly, Heated)
form: Solid
pka: 4.63±0.70(Predicted)
color: White to Pale Red
InChI: InChI=1/C30H48O6/c1-16-9-10-30(25(35)36)12-11-28(5)18(22(30)17(16)2)7-8-21-26(3)13-20(33)24(34)27(4,15-31)23(26)19(32)14-29(21,28)6/h7,16-17,19-24,31-34H,8-15H2,1-6H3,(H,35,36)/t16-,17+,19-,20-,21-,22+,23-,24+,26-,27+,28-,29-,30+/s3
InChIKey: PRAUVHZJPXOEIF-MRQYELSVNA-N
SMILES: C[C@]12C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]1([H])[C@H](O)C[C@]1([C@@]3(CC[C@]4(CC[C@@H](C)[C@H](C)[C@@]4([H])C3=CC[C@]21[H])C(=O)O)C)C |&1:1,3,5,7,11,13,16,17,20,23,25,27,32,r|
LogP: 4.321 (est)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11854
Product name: Madecassic Acid
Purity: ≥95%
Packaging: 100mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 11854
Product name: Madecassic Acid
Purity: ≥95%
Packaging: 1g
Price: $179
Updated: 2024/03/01

Cayman Chemical

Product number: 11854
Product name: Madecassic Acid
Purity: ≥95%
Packaging: 250mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 11854
Product name: Madecassic Acid
Purity: ≥95%
Packaging: 500mg
Price: $117
Updated: 2024/03/01

TRC

Product number: M107500
Product name: MadecassicAcid(97%)
Packaging: 250mg
Price: $265
Updated: 2021/12/16

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Madecassic acid Chemical Properties,Usage,Production

Description

Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E₂ (PGE₂; ), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 μg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; ). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.

Chemical Properties

White powder

Uses

wound healing

Uses

Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.

Definition

ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).

Madecassic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Madecassic acid Suppliers

Canada 1 China 295 Europe 2 Germany 3 India 1 United Kingdom 6 United States 20 Global 328

Shaanxi Pioneer Biotech CO., Ltd

Tel: 029-86107037-8019 15332321378
Email: sales@pioneerbiotech.com
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
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XiaoGan ShenYuan ChemPharm co,ltd

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Sichuan Kulinan Technology Co., Ltd

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China Langchem Inc.

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Country: China
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Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
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Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
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Country: China
ProdList: 9658
Advantage: 60

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View Lastest Price from Madecassic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Madecassic acid 18449-41-7
Price: US $99.00-45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-26

BINBO BIOLOGICAL CO.,LTD

Product: Madecassic acid 18449-41-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: >95%
Supply Ability: 1000 kg
Release date: 2024-04-09

Hebei Weibang Biotechnology Co., Ltd

Product: Madecassic acid 18449-41-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-26

18449-41-7, Madecassic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate ORIENTIN AURANTIO-OBTUSIN CALYCOSIN Stearic acid Centella asiatica extract Asiaticoside Citric acid Folic acid Ascoric Acid Asiatic acid 3,3,5,5-TETRAMETHYLCYCLOHEXANOL Madecassic acid Centella asiatica whole plant MADECASSIC ACID(SECONDARY STANDARD) MADECASSIC ACID(SH) MADECASSIC ACID 95% MADECASSIC ACID(PRIMARY STANDARD)

(2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxy-urs-12-en-28-oic acid

MADECASSIC ACID

Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2.alpha.,3.beta.,4.alpha.,6.beta.)-

(1S,2R,4aS,6aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bR)-8,10,11-trihydroxy -9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,1 1,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid

Hydroxy asiaticoside

MADECASSIC ACID(P)

6BETA-HYDROXYASIATIC ACID

2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid

6-Hydroxyasiatic acid

Madecasoside

Madecassic acid, 98%, from Centella asiatica (L.) Urb.

Madecassic acid, froM Centella asiatica

Urs-12-en-28-oic acid,2,3,6,23-tetrahydroxy-, (2a,3b,4a,6b)-

Brahmic acid 18449-41-7

Madecassic Acid (97%)

Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,4α,6β)-

(1S,2R,4aS,6aS,6bR,8R,9R,10R,11R,12aR)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid

(1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-8,10,11-Trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid

Hydroxycentella glycoside

Madecassic acid/Madecassoide

Hydroxyasiatic acid

Madecassic acid-RM

18449-41-7

C30H48O6

Inhibitors

Cofactor

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Miscellaneous Natural Products

The group of Asiaticoside