ORIENTIN

Product Name: ORIENTIN
CAS No.: 28608-75-5
Chemical Name: ORIENTIN
Synonyms: LUTEOLIN-8-C-GLUCOSIDE;Polygonin;Luteolin 8-C-β-D-glucopyranoside;lutexin;ORIENTIN;ORIENTINE;Aids026706;Aids-026706;ORIENTIN(P);ORIENTIN,NA
CBNumber: CB7710333
Molecular Formula: C21H20O11
Formula Weight: 448.38
MOL File: 28608-75-5.mol

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ORIENTIN Property

Melting point:: 260-285°C
Boiling point:: 816.1±65.0 °C(Predicted)
Density: 1.759±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: 1 M NaOH: soluble1mg/mL, clear, yellow-orange
pka: 6.24±0.40(Predicted)
form: powder
color: yellow
Stability:: Hygroscopic
InChIKey: PLAPMLGJVGLZOV-FYNBPVOANA-N
SMILES: C12OC(=CC(=O)C=1C(=CC(O)=C2[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)O)C1C=CC(O)=C(O)C=1 |&1:12,13,15,16,18,r|
LogP: 1.580 (est)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: DJ3009300
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O9765
Product name: Orientin
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $127.24
Updated: 2025/07/31

Sigma-Aldrich

Product number: 03810585
Product name: Orientin
Purity: primary pharmaceutical reference standard
Packaging: 10mg
Price: $692
Updated: 2025/07/31

TCI Chemical

Product number: O0503
Product name: Orientin
Packaging: 25MG
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: O0503
Product name: Orientin
Packaging: 100MG
Price: $215
Updated: 2025/07/31

Cayman Chemical

Product number: 25143
Product name: Orientin
Purity: ≥95%
Packaging: 25mg
Price: $61
Updated: 2024/03/01

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ORIENTIN Chemical Properties,Usage,Production

Description

Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; ) radicals with an IC₅₀ value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC₅₀ value of 11.7 μg/ml and a cytotoxic concentration (CC₅₀) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.

Chemical Properties

Yellow powder

Uses

Orientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects.

Definition

ChEBI: A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.

in vivo

Orientin (0.1–10 mg/kg for p.o.;once) inhibits allergic reaction in PCA mouse model^[1].
Orientin (10–40 mg/kg for i.p.;once daily for 12 days) has an anti-neuroinflammatory effect in SNL rat model^[2].

Animal Model:	PCA mouse model^[1]
Dosage:	0.1–10 mg/kg
Administration:	Oral gavage (p.o.); Euthanized mouse after 1 h
Result:	Significantly suppressed PCA reactions in PCA mouse model.

Animal Model:	SNL rat model^[2]
Dosage:	10, 20, 40 mg/kg
Administration:	Intraperitoneal injection (i.p.); Once daily for 12 days
Result:	Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model. Decreased the levels of IL-6, IL-1β and TNF-α. Increased the level of anti-inflammatory IL-10. Down-regulated the level of MDA.

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] NAN WU. Antioxidant activities of extracts and main components of Pigeonpea [Cajanus cajan (L.) Millsp.] leaves.[J]. Molecules, 2009, 14 3: 1032-1043. DOI: 10.3390/molecules14031032
[3] YAO-LAN LI . Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge[J]. Journal of ethnopharmacology, 2002, 79 3: Pages 365-368. DOI: 10.1016/s0378-8741(01)00410-x
[4] WONHWA LEE Jong S B Sae Kwang Ku. Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo[J]. Vascular pharmacology, 2014, 62 1: Pages 3-14. DOI: 10.1016/j.vph.2014.04.006

ORIENTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ORIENTIN Suppliers

Canada 1 China 258 Europe 1 France 2 Germany 5 India 2 Japan 2 South Korea 1 United Kingdom 7 United States 20 Global 299

Nantong Feiyu Biological Technology CO.,LTD

Tel: 0513-68819626; 15152877458
Fax: 0513-68669626
Email: feiyubio@163.com
Country: China
ProdList: 4817
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
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Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
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Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
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Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
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Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
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Shenzhen Sungening Bio-Tech Co., Ltd

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Fax: +86-0755-89594066/4038
Email: sales@sungening.com
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View Lastest Price from ORIENTIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Orientin 28608-75-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: Orientine 28608-75-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Orientine 28608-75-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

28608-75-5, ORIENTINRelated Search:

4-N-HEXYLPHENOL 5-ETHYL-2-HYDROXY-BENZALDEHYDE 1-(2-Hydroxy-5-methylphenyl)ethanone 4-Phenylbutanol ORIENTIN 4'-Hydroxy-3'-methylacetophenone (S)-(-)-3-BENZYLOXY-1,2-PROPANEDIOL 1-(3-METHYLPHENYL)ETHANOL (S)-(+)-1-Phenyl-1,2-ethanediol (S)-(+)-4-PHENYL-2-BUTANOL 1,2,3-HEPTANETRIOL 2-Benzyloxyethanol 2',4'-DIHYDROXY-3'-PROPYLACETOPHENONE 4-Hexylresorcinol Vitexin 1-O-BENZYL-RAC-GLYCEROL 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE HOMOORIENTIN(ISOORIENTIN)(P)

2-(3,4-Dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one

ORIDONIN (RG)

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-.beta.-D-glucopyranosyl-5,7-dihydroxy-

Aids026706

Aids-026706

8-Glucosylluteolin

ORIENTIN

ORIENTINE

LUTEOLIN-8-C-GLUCOSIDE

Orientin, froM PolygonuM orientale

Orientin,Lutexin

Orientin, 98%, from Polygonum orientale L.

2-(3,4-dihydroxyphenyl)-8-beta-d-glucopyranosyl-5,7-dihydroxy-4h-1-benzopyra

4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-8-beta-d-glucopyranosyl-5,7-dihy

luteolin8-glucoside

lutexin

orientin(flavone)

ORIENTIN(P)

ORIENTIN(SH)

ORIENTIN WITH HPLC

8-β-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone

Luteolin 8-C-β-D-glucopyranoside

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-(β-D-glucopyranosyl)-4H-1-benzopyran-4-one

2-(3,4-Dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one

Polygonin

Orientin, 98%, from Polygonum orientale

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-

8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone

Luteolin 8-C-beta-D-Glucopyranoside

ORIENTIN USP/EP/BP

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one

OrientinQ: What is Orientin Q: What is the CAS Number of Orientin Q: What is the storage condition of Orientin Q: What are the applications of Orientin

4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-8-b-D-glucopyranosyl-5,7-dihydroxy-

ORIENTIN,NA

Orientin, 10 mM in DMSO

Orientin 100 μg/mL in Acetonitrile:Water

28608-75-5

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Aromatics, Glucuronides, Pharmaceuticals, Intermediates & Fine Chemicals