1-(2-Hydroxy-5-methylphenyl)ethanone
- Product Name
- 1-(2-Hydroxy-5-methylphenyl)ethanone
- CAS No.
- 1450-72-2
- Chemical Name
- 1-(2-Hydroxy-5-methylphenyl)ethanone
- Synonyms
- Ethanone,1-(2-hydroxy-5-methylphenyl)-;o-Acetyl-p-cresol;1-(2-HYDROXY-5-METHYLPHENYL)ETHAN-1-ONE;2-ACETYL-4-METHYLPHENOL;2-HYDROXY-5-METHYLACETOPHENONE;2'EOS-61730;AURORA 16683;-Hydroxy-5'ASISCHEM D38759
- CBNumber
- CB7477191
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 1450-72-2.mol
1-(2-Hydroxy-5-methylphenyl)ethanone Property
- Melting point:
- 45-48 °C(lit.)
- Boiling point:
- 112-114°C 12mm
- Density
- 1.079
- refractive index
- 1.5369 (estimate)
- FEMA
- 4594 | 2-HYDROXY-5-METHYLACETOPHENONE
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO : 50 mg/mL (332.96 mM; Need ultrasonic)
- form
- powder to crystal
- pka
- 10.46±0.18(Predicted)
- color
- Light orange to Yellow to Green
- Odor
- at 1.00 % in dipropylene glycol. sweet heavy floral herbal
- Odor Type
- floral
- Water Solubility
- Insoluble in water.
- JECFA Number
- 2045
- BRN
- 1364840
- LogP
- 2.52
- CAS DataBase Reference
- 1450-72-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-(2-hydroxy-5-methylphenyl)-(1450-72-2)
- EPA Substance Registry System
- Ethanone, 1-(2-hydroxy-5-methylphenyl)- (1450-72-2)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H37601
- Product name
- 2′-Hydroxy-5′-methylacetophenone
- Purity
- 98%
- Packaging
- 10g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- H37601
- Product name
- 2′-Hydroxy-5′-methylacetophenone
- Purity
- 98%
- Packaging
- 50g
- Price
- $214
- Updated
- 2025/07/31
- Product number
- H0790
- Product name
- 2'-Hydroxy-5'-methylacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- H0790
- Product name
- 2'-Hydroxy-5'-methylacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $126
- Updated
- 2025/07/31
- Product number
- H505220
- Product name
- 1-(2-Hydroxy-5-methylphenyl)ethanone
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
1-(2-Hydroxy-5-methylphenyl)ethanone Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder
Uses
2'-Hydroxy-5'-methylacetophenone is used to produce 2-ethyl-4-methyl-phenol. It is used as an intermediate in organic synthesis.
Definition
ChEBI: 2'-Hydroxy-5'-methylacetophenone is an aromatic ketone.
Preparation
Obtained by treatment of methyl 4-hydroxy-6-methyl-coumarin-3-carboxylate with potassium hydroxide at 200° (82%).
Synthesis
140-39-6
1450-72-2
The general procedure for the synthesis of 2-hydroxy-5-methylacetophenone from p-cresyl acetate was as follows: p-tolyl acetate (10 g, 0.067 mol) and aluminum chloride (10.7 g, 0.08 mol) were added to a 500-mL round-bottomed flask. The reaction mixture was heated in an oil bath at 140-150°C for 5-6 hours. The reaction process was monitored by thin layer chromatography (TLC) using ethyl acetate:hexane as the unfolding agent. After completion of the reaction, the reaction mixture was quenched with crushed ice and the resulting solid product was extracted with ethyl acetate (2 x 50 mL). The organic phase was washed with brine solution (2 x 15 mL) and dried with anhydrous sodium sulfate. Subsequently, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by aqueous ethanol recrystallization to afford the target compound 2-hydroxy-5-methylacetophenone in 92% yield with a melting point of 45-48°C.
References
[1] Journal of Organic Chemistry, 1981, vol. 46, p. 4971 - 4975
[2] Journal of Chemical Research, Miniprint, 2003, # 12, p. 1258 - 1270
[3] Journal of Chemical Research, Synopses, 1999, # 9, p. 574 - 575
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 734 - 736
[5] Journal of Chemical Research, Miniprint, 1998, # 10, p. 2678 - 2695
1-(2-Hydroxy-5-methylphenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(2-Hydroxy-5-methylphenyl)ethanone manufacturers
- Product
- 1-(2-Hydroxy-5-methylphenyl)ethanone 1450-72-2
- Price
- US $4656.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-07-25
- Product
- 1-(2-Hydroxy-5-methylphenyl)ethanone 1450-72-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-08