SCIADOPITYSIN

Product Name: SCIADOPITYSIN
CAS No.: 521-34-6
Chemical Name: SCIADOPITYSIN
Synonyms: Nsc 45108;SCIADOPITYSIN;Einecs 208-311-5;Sciadopitysin-RM;SCIADOPITYSIN(SH);SCIADOPITYSIN(AS) 10mg;Sciadopitysin, 10 mM in DMSO;4',4''',7-Trimethoxyamentoflavone;AMENTOFLAVONE-7,4',4'-TRIMETHYL ETHER;Amentoflavone-4',4",7-trimethyl Ether
CBNumber: CB0273404
Molecular Formula: C33H24O10
Formula Weight: 580.54
MOL File: 521-34-6.mol

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SCIADOPITYSIN Property

Melting point:: 296-298°C
Boiling point:: 839.6±65.0 °C(Predicted)
Density: 1.445±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in ethanol and methan
form: powder
pka: 6.16±0.40(Predicted)
color: Light yellow
InChIKey: YCXRBCHEOFVYEN-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(OC)C=C2)OC2=C(C3=CC(C4OC5=CC(OC)=CC(O)=C5C(=O)C=4)=CC=C3OC)C(O)=CC(O)=C2C(=O)C=1
LogP: 5.500 (est)
CAS DataBase Reference: 521-34-6

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Safety

Safety Statements: 24/25
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27900
Product name: Sciadopitysin
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 27900
Product name: Sciadopitysin
Packaging: 50mg
Price: $841
Updated: 2024/03/01

Cayman Chemical

Product number: 27900
Product name: Sciadopitysin
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 27900
Product name: Sciadopitysin
Packaging: 25mg
Price: $513
Updated: 2024/03/01

Usbiological

Product number: 300938
Product name: Sciadopitysin
Packaging: 20mg
Price: $462
Updated: 2021/12/16

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SCIADOPITYSIN Chemical Properties,Usage,Production

Description

Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC₅₀ = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC₅₀ = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.

Chemical Properties

White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginkgo leaves and yew branches and leaves.

Uses

Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].

Definition

ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.

in vivo

Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)^[2].

target

IC 50

NF-κB

References

[1] Brian?on-Scheid F, et al. HPLC?Separation?and?Quantitative?Determination?of?Biflavones?in?Leaves?from?Ginkgo biloba. Planta Med.?1983 Dec;49(12):204-7. DOI:10.1055/s-2007-969851
[2] Sciadopitysin?suppresses?RANKL-mediated?osteoclastogenesis?and?prevents?boneloss?in?LPS-treated?mice. Int Immunopharmacol.?2017 Aug;49:109-117. DOI:10.1016/j.intimp.2017.05.029

SCIADOPITYSIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SCIADOPITYSIN Suppliers

China 153 France 1 Germany 2 Japan 1 United Kingdom 6 United States 13 USA 1 Global 177

Huzhou ZhanShu Biotechnology Co.,Ltd

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Shanghai Tauto Biotech Co., Ltd.

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TargetMol Chemicals Inc.

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View Lastest Price from SCIADOPITYSIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Sciadopitysin 521-34-6
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-19

Career Henan Chemical Co

Product: SCIADOPITYSIN 521-34-6
Price: US $350.00/KG
Min. Order: 1KG
Purity: 99.5%
Supply Ability: 10000kg
Release date: 2018-07-27

521-34-6, SCIADOPITYSINRelated Search:

4-Phenylphenol 3-Biphenylmethanol SCIADOPITYSIN 2-METHOXYBIPHENYL 3,3'-Dimethylbiphenyl 4-METHOXY-3-METHYLBENZYL ALCOHOL 4'-Hydroxy-3'-methylacetophenone 2-Phenylphenol 1-(2-Hydroxy-5-methylphenyl)ethanone 2,4-Dihydroxy-3-methylbenzaldehyde 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE 2,2'-DIMETHOXYBIPHENYL 4',7-DIMETHOXY-5-HYDROXYFLAVONE 2-PROPENAL, 3-(3-METHYLPHENYL)-,(2E) BILOBETIN 3-Phenylbenzaldehyde 4,6-DIMETHOXYSALICYLALDEHYDE 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE

AMENTOFLAVONE-7,4',4'''-TRIMETHYL ETHER

AMENTOFLAVONE-7,4',4''-TRIMETHYL ETHER

AMENTOFLAVONE-7,4',4'-TRIMETHYL ETHER

SCIADOPITYSIN

5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4-benzopyrone

SCIADOPITYSIN(SH)

AMENTOFLAVONE-7,4'',4''-TRIMETHYL ETHER WITH HPLC

2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5-hydroxy-7-methoxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one

2-(4-Methoxyphenyl)-8-[6-methoxy-3-(4-oxo-5-hydroxy-7-methoxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one

4',4''',7-Trimethoxyamentoflavone

5,5'',7''-Trihydroxy-4',4''',7-trimethoxy-3',8''-biflavone

5,7-Dihydroxy-8-[2-methoxy-5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

5,7-Dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-methoxyphenyl)-4-benzopyrone

Einecs 208-311-5

Nsc 45108

4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-

5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one

Sciadopitysin, 95%, from Ginkgo biloba L.

Amentoflavone-4',4",7-trimethyl Ether

SCIADOPITYSIN(AS) 10mg

Sciadopitysin-RM

Sciadopitysin, 10 mM in DMSO

5,7-Dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-2-(4-methoxyphenyl)-4H-chromen-4-one

521-34-6

C33H24O10

Tri-substituted Flavones