4',7-DIMETHOXY-5-HYDROXYFLAVONE

Product Name: 4',7-DIMETHOXY-5-HYDROXYFLAVONE
CAS No.: 5128-44-9
Chemical Name: 4',7-DIMETHOXY-5-HYDROXYFLAVONE
Synonyms: Dimethoxylapigenin;4’7-Dimethoxylapigenin;4',7-DIMETHOXYAPIGENIN;apigenin dimethylether;4'-Di-O-methylapigenin;4',7-O-DIMETHYLAPIGENIN;7,4'-Di-O-methylapigenin;ACACETIN 7-O-METHYL ETHER;Genkwanin 4'-methyl ether;7,4''-Di-O-methylapigenin
CBNumber: CB6447665
Molecular Formula: C17H14O5
Formula Weight: 298.29
MOL File: 5128-44-9.mol

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4',7-DIMETHOXY-5-HYDROXYFLAVONE Property

Melting point:: 139-140 °C
Boiling point:: 515.2±50.0 °C(Predicted)
Density: 1.321±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : 5 mg/mL (16.76 mM; Need ultrasonic)
form: powder
pka: 6.35±0.40(Predicted)
color: Yellow
InChI: InChI=1S/C17H14O5/c1-20-11-5-3-10(4-6-11)15-9-14(19)17-13(18)7-12(21-2)8-16(17)22-15/h3-9,18H,1-2H3
InChIKey: LZERJKGWTQYMBB-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(OC)C=C2)OC2=CC(OC)=CC(O)=C2C(=O)C=1
LogP: 3.444 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1876
Product name: 7,4'-Di-O-methylapigenin
Purity: min. 95.0 %
Packaging: 25MG
Price: $165
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FA65396
Product name: Acacetin 7-O-methyl ether
Packaging: 2mg
Price: $40
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA65396
Product name: Acacetin 7-O-methyl ether
Packaging: 5mg
Price: $82.5
Updated: 2021/12/16

AK Scientific

Product number: W1635
Product name: 7,4'-Di-O-methylapigenin
Packaging: 2mg
Price: $103
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA65396
Product name: Acacetin 7-O-methyl ether
Packaging: 10mg
Price: $130
Updated: 2021/12/16

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4',7-DIMETHOXY-5-HYDROXYFLAVONE Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]

Definition

ChEBI: A dimethoxyflavone that is the 7,4'-dimethyl ether derivative of apigenin.

IC 50

Human Endogenous Metabolite

References

[1] Alvarez, M.E. et al.Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke.Farmaco. Jun-Jul;55(6-7):502-5.doi:10.1016/S0014-827X(00)00067-7(2000). DOI:10.1016/s0014-827x(00)00067-7
[2] Mangoyi, R., Midiwo, J. & Mukanganyama, S. Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. BMC complementary and alternative medicine 15, 405, doi:10.1186/s12906-015-0934-7 (2015). DOI:10.1186/s12906-015-0934-7

4',7-DIMETHOXY-5-HYDROXYFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4',7-DIMETHOXY-5-HYDROXYFLAVONE Suppliers

China 123 India 1 United Kingdom 4 United States 11 USA 1 Global 140

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View Lastest Price from 4',7-DIMETHOXY-5-HYDROXYFLAVONE manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: 4',7-Dimethoxy-5-Hydroxyflavone 5128-44-9 5128-44-9
Price: US $18.50/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-19

Career Henan Chemical Co

Product: apigenin 7,4'-dimethyl ether 5128-44-9
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

5128-44-9, 4',7-DIMETHOXY-5-HYDROXYFLAVONERelated Search:

KAEMPFEROL-3,7,4'-TRIMETHYL ETHER 3',4',5',5,7-PENTAMETHOXYFLAVONE 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER 5-HYDROXY-7,4'-DIMETHOXY-6,8-DIMETHYLFLAVONE 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE 3,7,3',4'-TETRAMETHYLGOSSYPETIN Diosmin 4',7-DIMETHOXY-5-HYDROXYFLAVONE 3',4',5,7-TETRAMETHOXYFLAVONE SCUTELLAREIN TETRAMETHYL ETHER SCIADOPITYSIN EUPATORIN-5-METHYL ETHER 5-HYDROXYFLAVONE Acacetin Apigenin Tangeretin

4',7-Dimethoxy-5-Hydroxyflavone 5128-44-9

4’7-Dimethoxylapigenin

4',7-DIMETHOXY-5-HYDROXYFLAVONE

4',7-DIMETHOXYAPIGENIN

4',7-O-DIMETHYLAPIGENIN

ACACETIN 7-O-METHYL ETHER

5-Hydroxy-4',7-dimethoxyflavone

5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

7,4'-Di-O-methylapigenin

Apigenin 4',7-dimethyl ether

Apigenin 7,4'-dimethyl ether

Genkwanin 4'-methyl ether

5-Hydroxy-7-Methoxy-2-(4-Methoxyphenyl)-4H-chroMen-4-one

5-hydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one

APIGENIN-4',7-DI-O-METHYL ETHER

5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4-benzopyrone

apigenin dimethylether

Dimethoxylapigenin

4'-Di-O-methylapigenin

4H-1-Benzopyran-4-one, 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-

5-Hydroxy 4',7-dimethoxyflavone

7,4''-Di-O-methylapigenin

7,4''-Di-O-methylapigenin, 10 mM in DMSO

5128-44-9

Tri-substituted Flavones