Acacetin
- Product Name
- Acacetin
- CAS No.
- 480-44-4
- Chemical Name
- Acacetin
- Synonyms
- Abietic;acacetine;5,7-dihydroxy-4’-methoxy-flavon;ACACETIN;LY 064233;NSC 76061;Linarisenin;LINARIGENIN;Acacetin-RM;ACACETIN hplc
- CBNumber
- CB9316535
- Molecular Formula
- C16H12O5
- Formula Weight
- 284.26
- MOL File
- 480-44-4.mol
Acacetin Property
- Melting point:
- 260-265 °C(lit.)
- Boiling point:
- 346.76°C (rough estimate)
- Density
- 1.2160 (rough estimate)
- refractive index
- 1.6200 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Very Slightly, Heated)
- form
- Solid
- pka
- 6.51±0.40(Predicted)
- color
- Light Yellow to Green-Yellow to Dark Yellow
- λmax
- 335nm(EtOH)(lit.)
- Merck
- 14,13
- BRN
- 277879
- InChIKey
- DANYIYRPLHHOCZ-UHFFFAOYSA-N
- LogP
- 2.443 (est)
- CAS DataBase Reference
- 480-44-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PHL89482
- Product name
- Acacetin
- Purity
- phyproof? Reference Substance
- Packaging
- 20mg
- Price
- $146.4
- Updated
- 2024/03/01
- Product number
- 49975
- Product name
- Acacetin
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $247
- Updated
- 2022/05/15
- Product number
- A3013
- Product name
- Acacetin
- Purity
- >98.0%(GC)
- Packaging
- 25mg
- Price
- $173
- Updated
- 2024/03/01
- Product number
- A3013
- Product name
- Acacetin
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $344
- Updated
- 2024/03/01
- Product number
- 20827
- Product name
- Acacetin
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $121
- Updated
- 2024/03/01
Acacetin Chemical Properties,Usage,Production
Description
Acacetin is an O-methylated flavone found in various plants. It is reported to demonstrate spasmolytic, antinociceptive, anti-inflammatory, and antioxidant activity in various research models.
Chemical Properties
Yellow Solid
Uses
VEGF expression inhibitor and tumor angiogenesis. A flavonoid with antiaggregatory activity in human blood.
Definition
ChEBI: A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 6497, 1990 DOI: 10.1016/S0040-4039(00)97100-4
General Description
Acacetin belongs to the category of naturally occurring plant pigments called flavonoids found in vascular plants. It was first reported to be extracted from the leaves of Robinia pseuducacia. It has been used as an active component of traditional Chinese medicine Xuelianhua.
Biochem/physiol Actions
Acacetin has been noted to exhibit anti-peroxidative, anti-inflammatory, and anti-plasmodial properties. It has been posited to prevent the proliferation of Hep G2 cells, thereby causing cell apoptosis and subsequent anti-cancer action. It has antiarrhythmic properties and can be used in the treatment of Atrial fibrillation.
Enzyme inhibitor
This naturally occurring flavone (FW = 286.27 g/mol; CAS 480-44-4), also known as 5,7-dihydroxy-4’-methoxyflavone and 7-O-methylapigenin, and systematically named as 5,7-dihydroxy-2-(4-methoxyphenyl)-chromen-4- one, from the black locust Robinia pseudoacacia is the aglycon of linarin and acaciin and is biosynthesized by apigenin 4'-O-methyltransferase from S-adenosyl-methionine and 5,7,4’-trihydroxyflavone (apigenin), yielding Sadenosylhomocysteine and acacetin. The chemical synthesis of acacetin was accomplished by Robert Robinson, who was awarded the 1947 Nobel Prize in Chemistry for his work on alkaloids and organic synthesis. Target(s): glutathione S-transferase; xanthine oxidase, Ki = 0.11 μM; CYP1A; CYP1B1; glutathione-disulfide reductase; DNA topoisomerase I; [myosin light-chain] kinase; and protein-tyrosine kinase, or non-specific protein-tyrosine kinase.
Acacetin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acacetin manufacturers
- Product
- Acacetin 480-44-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥98%
- Supply Ability
- 20tons
- Release date
- 2024-01-05
- Product
- Acacetin 480-44-4
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-12-10
- Product
- Acacetin 480-44-4
- Price
- US $725.00/kg
- Min. Order
- 1kg
- Purity
- 98% HPLC
- Supply Ability
- 20 tons
- Release date
- 2022-10-20