ARTEMISININ
- Product Name
- ARTEMISININ
- CAS No.
- 491-54-3
- Chemical Name
- ARTEMISININ
- Synonyms
- KAEMPFERIDE;ARTEANNUIN;ARTEMISIA ANNUA;kaempferid;ARTEANUIN;QINGHAOSA;Kaemperide;ARTEMISINE;Kempferide;CaMpheride
- CBNumber
- CB0387974
- Molecular Formula
- C16H12O6
- Formula Weight
- 300.26
- MOL File
- 491-54-3.mol
ARTEMISININ Property
- Melting point:
- 156-157 °C(lit.)
- Boiling point:
- 543.8±50.0 °C(Predicted)
- Density
- 1.538
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, Heat
- pka
- 6.32±0.40(Predicted)
- form
- Solid
- color
- Yellow
- BRN
- 305378
- LogP
- 2.740 (est)
- CAS DataBase Reference
- 491-54-3
Safety
- Safety Statements
- 24/25
- WGK Germany
- 2
- RTECS
- KD4170000
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 69545
- Product name
- Kaempferide
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $548
- Updated
- 2024/03/01
- Product number
- K0057
- Product name
- Kaempferide
- Purity
- >96.0%(GC)
- Packaging
- 10mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- K0057
- Product name
- Kaempferide
- Purity
- >96.0%(GC)
- Packaging
- 50mg
- Price
- $385
- Updated
- 2024/03/01
- Product number
- 29673
- Product name
- Kaempferide
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 29673
- Product name
- Kaempferide
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
ARTEMISININ Chemical Properties,Usage,Production
Chemical Properties
Yellow powder
Uses
Kaempferide is a flavonoid that maintains anti-radical and anti-oxidant capabilities, as well as anti-tumour possibilities. Impurity of Icaritin (I163700).
Definition
ChEBI: A monomethoxyflavone that is the 4'-O-methyl derivative of kaempferol.
Biological Activity
the effects of phytoestrogens have been studied in the hypothalamic-pituitary-gonadal axis and various non-gonadal targets. epidemiologic and experimental evidence indicates a protective effect of phytoestrogens also in colorectal cancer. the mechanism through which estrogenic molecules control colorectal cancer tumorigenesis could possibly involve estrogen receptor β, which is the predominantly expressed estrogen receptor subtype in colon mucosa.
in vitro
kaempferide triglycoside proved to inhibit the proliferation of native and estrogen receptor β overexpressing colon cancer cells via a mechanism not mediated by ligand binding dependent estrogen receptor activation. it affected hct8 cell cycle progression through increasing the g0/g1 cell fraction and in estrogen receptor β overexpressing cells increased two antioxidant enzymes [1].
in vivo
the aim of one previous study was to evaluate the effect of kaempferol on tissue lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal cancer in male wistar rats and to compare its efficacy with irinotecan. this study revealed that kaempferol could be safely used as a chemopreventive agent in colorectal cancer [2].
References
[1] martineti v, tognarini i, azzari c, carbonell sala s, clematis f, dolci m, lanzotti v, tonelli f, brandi ml, curir p. inhibition of in vitro growth and arrest in the g0/g1 phase of hct8 line human colon cancer cells by kaempferide triglycoside from dianthus caryophyllus. phytother res. 2010 sep;24(9):1302-8.
[2] nirmala p, ramanathan m. effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats. eur j pharmacol. 2011 mar 1;654(1):75-9.
ARTEMISININ Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ARTEMISININ manufacturers
- Product
- ARTEMISININ 491-54-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-09-27
- Product
- Kaempferide 491-54-3
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-12-27
- Product
- ARTEMISININ 491-54-3
- Price
- US $302.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2018-07-27