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KAEMPFEROL-3-O-RUTINOSIDE

Product Name
KAEMPFEROL-3-O-RUTINOSIDE
CAS No.
17650-84-9
Chemical Name
KAEMPFEROL-3-O-RUTINOSIDE
Synonyms
NICOTIFLORIN;Nictoflorin;KAEMPFEROL-3-RUTINOSIDE;Nicotiflorine;Aempferol-3-O-rutinoside;Nicotifiorin;Nictoflorin (incorr;Kaempferol-3-O-rutinosid;Kaempferol-3-O-beta-rutinoside;Rutoside Trihydrate EP Impurity B
CBNumber
CB6690629
Molecular Formula
C27H30O15
Formula Weight
594.52
MOL File
17650-84-9.mol
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KAEMPFEROL-3-O-RUTINOSIDE Property

Melting point:
200°C (dec.)
Boiling point:
941.7±65.0 °C(Predicted)
Density 
1.76
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
6.20±0.40(Predicted)
color 
Off-White to Yellow
biological source
plant (Clematis cultivar)
Stability:
Hygroscopic
InChIKey
RTATXGUCZHCSNG-FVJKAJKWNA-N
SMILES
C1(O[C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](CO[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)O2)O)C(=O)C2=C(C=C(O)C=C2O)OC=1C1C=CC(O)=CC=1 |&1:2,3,5,6,8,11,13,14,16,18,r|
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-45-24/25
WGK Germany 
3
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
90242
Product name
Kaempferol 3-O-β -rutinoside
Purity
≥98.0% (HPLC)
Packaging
1mg
Price
$161
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL80700
Product name
Kaempferol 3-rutinoside
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$489
Updated
2025/07/31
Sigma-Aldrich
Product number
90242
Product name
Kaempferol 3-O-β -rutinoside
Purity
≥98.0% (HPLC)
Packaging
5mg
Price
$292
Updated
2025/07/31
Cayman Chemical
Product number
27392
Product name
Nicotiflorin
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
27392
Product name
Nicotiflorin
Packaging
25mg
Price
$893
Updated
2024/03/01
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KAEMPFEROL-3-O-RUTINOSIDE Chemical Properties,Usage,Production

Description

Nicotiflorin is a flavonoid that has been found in I. glandulifera and has antioxidant and neuroprotective activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals with EC50 values of 0.52 and 0.48 mg/ml, respectively, in cell-free assays. Nicotiflorin (1 μM) prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in primary rat mesencephalic neurons. It decreases infarct volume by 24.5, 45.8, and 63.2% when administered at doses of 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient middle central artery occlusion (MCAO).

Chemical Properties

Light yellow needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Sophora japonica seeds and safflower.

Uses

Kaempferol 3-O-β -Rutinoside is a flavonoid antioxidant compound from Cichorium spinosum L. ecotype plants and also may display anti-diabetic activity. It is a component of many plant species including Helianthemum ruficomum.

Definition

ChEBI: Kaempferol-3-rutinoside is a kaempferol O-glucoside that is kaempferol attached to a rutinosyl [6-deoxy-alpha-L-mannosyl-(1->6)-beta-D-glucosyl] residue at position 3 via a glycosidic linkage. It has been isolated from the leaves of Solanum campaniforme. It has a role as a metabolite, a radical scavenger and a plant metabolite. It is a rutinoside, a trihydroxyflavone, a disaccharide derivative and a kaempferol O-glucoside.

General Description

Kaempferol 3-O-β -rutinoside is a bitter tasting flavonol glycoside that was isolated from flowers of a Clematis cultivar.

in vivo

At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits[2]. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits[3].

References

[1] KATARZYNA SZEWCZYK . Phenolic constituents of the aerial parts of Impatiens glandulifera Royle (Balsaminaceae) and their antioxidant activities[J]. Natural Product Research, 2019, 33 19: Pages 2851-2855. DOI: 10.1080/14786419.2018.1499644
[2] WEI QU . Kaempferol Derivatives Prevent Oxidative Stress–Induced Cell Death in a DJ-1–Dependent Manner[J]. Journal of pharmacological sciences, 2009, 110 2: Pages 191-200. DOI: 10.1254/jphs.09045fp
[3] RUNPING LI . Nicotiflorin reduces cerebral ischemic damage and upregulates endothelial nitric oxide synthase in primarily cultured rat cerebral blood vessel endothelial cells[J]. Journal of ethnopharmacology, 2006, 107 1: Pages 143-150. DOI: 10.1016/j.jep.2006.04.024

KAEMPFEROL-3-O-RUTINOSIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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KAEMPFEROL-3-O-RUTINOSIDE Suppliers

China 242 France 1 Germany 2 India 1 Japan 1 United Kingdom 6 United States 17 USA 1 Global 271
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
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China
ProdList
4999
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Jiangsu Yongjian Pharmaceutical Technology Co., Ltd
Tel
17701422015
Email
3582572959@qq.com
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China
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979
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58
Chengdu RefMedic Biotech Co Ltd
Tel
028-82253651 18140204969
Email
sales@refmedic.com
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China
ProdList
2260
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58
Hubei Danding Pharmaceutical Technology Co., Ltd
Tel
17701422019
Email
1559451077@qq.com
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China
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8171
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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Chembest Research Laboratories Limited
Tel
+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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Sichuan Kulinan Technology Co., Ltd
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400-1166-196 18981987031
Fax
028-84555506 800101999
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cdhxsj@163.com
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China
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11705
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Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
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China
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4747
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BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
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Chengdu Ai Keda Chemical Technology Co., Ltd.
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4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
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9718
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View Lastest Price from KAEMPFEROL-3-O-RUTINOSIDE manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Kaempferol-3-O-rutinoside 17650-84-9
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-12-18
Career Henan Chemical Co
Product
KAEMPFEROL-3-O-RUTINOSIDE 17650-84-9
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/kg/t
Release date
2019-12-20

17650-84-9, KAEMPFEROL-3-O-RUTINOSIDERelated Search:

ARTEMISININ Sanggenon C kaempferol 3-O-sophoroside KaeMpferol-4'-O-β-D-glucopyranoside Kaempferol KAEMPFERITRIN KAEMPFEROL-7-O-GLUCOSIDE Kaempferol 3-neohesperidoside Kaempferol 3-(6-O-glucopyranosylglucoside) Kaempferol 3-sophoroside-7-glucoside KaeMpferol 3-sophoroside-7-rhaMnoside KAEMPFEROL 3-A-L-ARABINOPYRANOSIDE 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-benzopyran-4-one kaempferol-3-O-galactoside KaeMpferol 7-O-rhaMnoside KAEMPFEROL-3-GLUCURONIDE Kaempferol-3-O-(2,6-di-O-trans-p-coumaroyl)-beta-D-glucopyranoside kaempferol-3-O-glucosyl(1-2)rhamnoside

  • KaeMpferol-3-O-rutinoside, Nicotiflorin
  • Nictoflorin (incorr
  • 4H-1-Benzopyran-4-one,3-[[6-O-(6-deoxy-a-L-Mannopyranosyl)-b-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
  • 3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside
  • KaeMpferol-3-O-rutinosid, froM CarthaMus tinctorius
  • Kaempferol-3-O-rutinosid
  • Aempferol-3-O-rutinoside
  • NICOTIFLORIN
  • KAEMPFEROL-3-O-RUTINOSIDE
  • KAEMPFEROL-3-RUTINOSIDE
  • Kaempfeol-3-O-rutinoside
  • KAEMPFEROL-3-O-RUTINOSIDE WITH HPLC
  • KAEMPFEROL-3-RUTINOSIDE hplc
  • 3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(4-hydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • Kaempferol 3-rhamnoglucoside
  • Nicotoflorin
  • Kaempferol-3-O-rutinosid ,98%
  • 3-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • Nicotifiorin
  • Nicotiflorine
  • Nicotifloroside
  • Kaempferol-3-O-rutinosid, 98%, from Carthamus tinctorius L.
  • Kaempferol-3-O-rutinosid, ≥98.0%(HPLC)
  • Rutoside Trihydrate Impurity 2（Rutoside Trihydrate EP Impurity B）
  • Rutoside Trihydrate EP Impurity B
  • Nicotiflorin (Kaempferol-3-O-beta-Rutinoside)
  • Nictoflorin
  • Kaempferol-3-O-beta-rutinoside
  • Rutoside EP Impurity B
  • 4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
  • Kaempferol 3-O-β -Rutinoside (Nicotiflorin)
  • Kaempferol 3-O-beta -Rutinoside (Nicotiflorin)
  • Kaempferol 3-O-β -rutinoside
  • 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
  • 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
  • Kaempferol 3-rutinoside-RM
  • Rutoside Trihydrate EP Impurity B (Kaempferol-3-O-Beta-Rutinoside)
  • Kaempferol 3-O-b -Rutinoside (Nicotiflorin)
  • Kaempferol 3-<i>O</i>-β -rutinoside
  • Nicotiflorin (Kaempferol-3-O-rutinoside)
  • 17650-84-9
  • Tetra-substituted Flavones
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract