Kaempferol
Pharmacological effects Mechanism of action Bioactivity- Product Name
- Kaempferol
- CAS No.
- 520-18-3
- Chemical Name
- Kaempferol
- Synonyms
- kaempherol;kempferol;KAEMPFEROL 98%;3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one;campherol;pelargidenolon;Kaempferol Hydrate;3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one;3,4';asurone
- CBNumber
- CB5223176
- Molecular Formula
- C15H10O6
- Formula Weight
- 286.24
- MOL File
- 520-18-3.mol
Kaempferol Property
- Melting point:
- 276°C
- Boiling point:
- 348.61°C (rough estimate)
- Density
- 1.2981 (rough estimate)
- refractive index
- 1.4413 (estimate)
- storage temp.
- 2-8°C
- solubility
- ethanol: 20 mg/mL
- form
- powder
- Colour Index
- 75640
- pka
- 6.34±0.40(Predicted)
- color
- yellow
- Merck
- 14,5274
- BRN
- 304401
- Stability:
- Unstable in Solution
- InChIKey
- IYRMWMYZSQPJKC-UHFFFAOYSA-N
- LogP
- 2.685 (est)
- CAS DataBase Reference
- 520-18-3(CAS DataBase Reference)
- IARC
- 3 (Vol. 31, Sup 7) 1987
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-68-25
- Safety Statements
- 26-36-45-36/37-36/37/38-22
- RIDADR
- 2811
- WGK Germany
- -
- RTECS
- LK9275200
- F
- 8-10-23
- HS Code
- 29329990
- Hazardous Substances Data
- 520-18-3(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR2705
- Product name
- Kaempferol
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 30?mg
- Packaging
- 30MG
- Price
- $400
- Updated
- 2024/03/01
- Product number
- PHL89235
- Product name
- Kaempferol
- Purity
- phyproof? Reference Substance
- Packaging
- 20MG
- Price
- $423
- Updated
- 2024/03/01
- Product number
- 1354900
- Product name
- Kaempferol
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 15mg
- Price
- $429
- Updated
- 2024/03/01
- Product number
- 00550580
- Product name
- Kaempferol
- Purity
- primary reference standard
- Packaging
- 10mg
- Price
- $497
- Updated
- 2023/01/07
- Product number
- K0018
- Product name
- Kaempferol Hydrate
- Purity
- >97.0%(HPLC)
- Packaging
- 1g
- Price
- $974
- Updated
- 2024/03/01
Kaempferol Chemical Properties,Usage,Production
Pharmacological effects
Kaempferol (3,5,7‐trihydroxy‐2‐[4‐hydroxyphenyl]‐4H‐1‐benzopyran‐4‐one) is a yellow bioactive flavonoid, which is present inmany edible plants such as tea, cabbage, broccoli, endive, kale, beans, tomato, strawberries, leek, and grapes. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Its efficacy, a broad range of activity, and low toxicity compared with other examined compounds, make it an attractive chemical in the fight against diseases (including cancer).
Mechanism of action
Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3‐kinase (PI3K)/AKT (protein kinase B) and human T‐cell leukemia/lymphoma virus‐I (HTLV-I) signaling pathways, suppresses protein expression of epithelial‐mesenchymal transition (EMT)‐related markers including N‐cadherin, E‐cadherin, Slug, and Snail, and metastasis‐related markers such as matrix metallopeptidase 2 (MMP-2).
Bioactivity
As an anti‐oxidant, kaempferol counteracts production of superoxide ions and lowers the formation of reactive oxygen and nitrogen species. It also scavenges Fenton‐generated hydroxyl radical, peroxynitrite, and hydroxyl radicals. Furthermore, kaempferol suppresses the activity of xanthine oxidase and enhances the activities of catalase, heme oxygenase‐1, and superoxide dismutase.
Chemical Properties
Yellow Solid
Uses
antidepressant, inhibits fatty acid amide hydrolase
Uses
Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.
Uses
Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.
Definition
ChEBI: Kaempferol is a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment. It has a role as an antibacterial agent, a plant metabolite, a human xenobiotic metabolite, a human urinary metabolite, a human blood serum metabolite and a geroprotector. It is a member of flavonols, a 7-hydroxyflavonol and a tetrahydroxyflavone. It is a conjugate acid of a kaempferol oxoanion.
General Description
Kaempferol is a polyphenolic antioxidant abundantly present in vegetables and fruits. It has a diphenylpropane structure. In many plants, it is present as a glycosidic form namely, kaempferol-3-O-glucoside.
Biological Activity
Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca 2+ uniporter (EC 50 = 7 μ M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro .
Biochem/physiol Actions
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.
Anticancer Research
Kaempferol is one of the secondary metabolites found in some plants, plant-derivedfoods, and traditional medicines. It is a flavonoid compound obtained from someedible plants including grapes, tea, strawberries, broccoli, tomato, cabbage, leek,kale, endive, and beans. It inhibits growth and migration of pancreatic cancer cellsby acting on proto-oncogene tyrosine kinase (Src), ERK1/2, and AKT pathways(Singh et al. 2016a). It is being investigated in pancreatic and lung cancers toevaluate its antiangiogenic, anticancer, and radical scavenging activities. It showsmoderate cytostatic activity in PC3, HeLa, and K562 human cancer cells. It isidentified as aryl hydrocarbon receptor antagonist and acts against ABCG2 (ATP-bindingcassette subfamily G member 2)-mediated multidrug resistance bypreventing the ABCG2 upregulation in esophageal carcinoma. It induces theapoptosis of ovarian cancer cell by activating p53 in intrinsic pathway mechanism.It is an inhibitor of breast cancer resistance protein (BCRP), quinine reductase-2,and a substrate of BCRP (Calderon-Montano et al. 2011; Wang et al. 2012).
storage
Store at +4°C
Kaempferol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Kaempferol manufacturers
- Product
- Kaempferol 520-18-3
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-29
- Product
- Kaempferol 520-18-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 200000
- Release date
- 2023-08-15
- Product
- Kaempferol 520-18-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-22