ChemicalBook > CAS DataBase List > KAEMPFEROL-3-O-RUTINOSIDE

KAEMPFEROL-3-O-RUTINOSIDE

Product Name: KAEMPFEROL-3-O-RUTINOSIDE
CAS No.: 17650-84-9
Chemical Name: KAEMPFEROL-3-O-RUTINOSIDE
Synonyms: NICOTIFLORIN;Nictoflorin;KAEMPFEROL-3-RUTINOSIDE;Nicotiflorine;Aempferol-3-O-rutinoside;Nicotifiorin;Nictoflorin (incorr;Kaempferol-3-O-rutinosid;Kaempferol-3-O-beta-rutinoside;Rutoside Trihydrate EP Impurity B
CBNumber: CB6690629
Molecular Formula: C27H30O15
Formula Weight: 594.52
MOL File: 17650-84-9.mol

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KAEMPFEROL-3-O-RUTINOSIDE Property

Melting point:: 200°C (dec.)
Boiling point:: 941.7±65.0 °C(Predicted)
Density: 1.76
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 6.20±0.40(Predicted)
color: Off-White to Yellow
biological source: plant (Clematis cultivar)
Stability:: Hygroscopic
InChIKey: RTATXGUCZHCSNG-FVJKAJKWNA-N
SMILES: C1(O[C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](CO[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)O2)O)C(=O)C2=C(C=C(O)C=C2O)OC=1C1C=CC(O)=CC=1 |&1:2,3,5,6,8,11,13,14,16,18,r|

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-45-24/25
WGK Germany: 3
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 90242
Product name: Kaempferol 3-O-β -rutinoside
Purity: ≥98.0% (HPLC)
Packaging: 1mg
Price: $161
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL80700
Product name: Kaempferol 3-rutinoside
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $489
Updated: 2025/07/31

Sigma-Aldrich

Product number: 90242
Product name: Kaempferol 3-O-β -rutinoside
Purity: ≥98.0% (HPLC)
Packaging: 5mg
Price: $292
Updated: 2025/07/31

Cayman Chemical

Product number: 27392
Product name: Nicotiflorin
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 27392
Product name: Nicotiflorin
Packaging: 25mg
Price: $893
Updated: 2024/03/01

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KAEMPFEROL-3-O-RUTINOSIDE Chemical Properties,Usage,Production

Description

Nicotiflorin is a flavonoid that has been found in I. glandulifera and has antioxidant and neuroprotective activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and ABTS radicals with EC₅₀ values of 0.52 and 0.48 mg/ml, respectively, in cell-free assays. Nicotiflorin (1 μM) prevents hydrogen peroxide-induced decreases in tyrosine hydroxylase activity in PC12 cells and cell death in primary rat mesencephalic neurons. It decreases infarct volume by 24.5, 45.8, and 63.2% when administered at doses of 2.5, 5, and 10 mg/kg, respectively, in a rat model of cerebral ischemia-reperfusion injury induced by transient middle central artery occlusion (MCAO).

Chemical Properties

Light yellow needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Sophora japonica seeds and safflower.

Uses

Kaempferol 3-O-β -Rutinoside is a flavonoid antioxidant compound from Cichorium spinosum L. ecotype plants and also may display anti-diabetic activity. It is a component of many plant species including Helianthemum ruficomum.

Definition

ChEBI: Kaempferol-3-rutinoside is a kaempferol O-glucoside that is kaempferol attached to a rutinosyl [6-deoxy-alpha-L-mannosyl-(1->6)-beta-D-glucosyl] residue at position 3 via a glycosidic linkage. It has been isolated from the leaves of Solanum campaniforme. It has a role as a metabolite, a radical scavenger and a plant metabolite. It is a rutinoside, a trihydroxyflavone, a disaccharide derivative and a kaempferol O-glucoside.

General Description

Kaempferol 3-O-β -rutinoside is a bitter tasting flavonol glycoside that was isolated from flowers of a Clematis cultivar.

in vivo

At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits^[2]. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits^[3].

References

[1] KATARZYNA SZEWCZYK . Phenolic constituents of the aerial parts of Impatiens glandulifera Royle (Balsaminaceae) and their antioxidant activities[J]. Natural Product Research, 2019, 33 19: Pages 2851-2855. DOI: 10.1080/14786419.2018.1499644
[2] WEI QU . Kaempferol Derivatives Prevent Oxidative Stress–Induced Cell Death in a DJ-1–Dependent Manner[J]. Journal of pharmacological sciences, 2009, 110 2: Pages 191-200. DOI: 10.1254/jphs.09045fp
[3] RUNPING LI . Nicotiflorin reduces cerebral ischemic damage and upregulates endothelial nitric oxide synthase in primarily cultured rat cerebral blood vessel endothelial cells[J]. Journal of ethnopharmacology, 2006, 107 1: Pages 143-150. DOI: 10.1016/j.jep.2006.04.024

KAEMPFEROL-3-O-RUTINOSIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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KAEMPFEROL-3-O-RUTINOSIDE Suppliers

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View Lastest Price from KAEMPFEROL-3-O-RUTINOSIDE manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Kaempferol-3-O-rutinoside 17650-84-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-18

Career Henan Chemical Co

Product: KAEMPFEROL-3-O-RUTINOSIDE 17650-84-9
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/kg/t
Release date: 2019-12-20

17650-84-9, KAEMPFEROL-3-O-RUTINOSIDERelated Search:

ARTEMISININ Sanggenon C kaempferol 3-O-sophoroside KaeMpferol-4'-O-β-D-glucopyranoside Kaempferol KAEMPFERITRIN KAEMPFEROL-7-O-GLUCOSIDE Kaempferol 3-neohesperidoside Kaempferol 3-(6-O-glucopyranosylglucoside) Kaempferol 3-sophoroside-7-glucoside KaeMpferol 3-sophoroside-7-rhaMnoside KAEMPFEROL 3-A-L-ARABINOPYRANOSIDE 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-benzopyran-4-one kaempferol-3-O-galactoside KaeMpferol 7-O-rhaMnoside KAEMPFEROL-3-GLUCURONIDE Kaempferol-3-O-(2,6-di-O-trans-p-coumaroyl)-beta-D-glucopyranoside kaempferol-3-O-glucosyl(1-2)rhamnoside

KaeMpferol-3-O-rutinoside, Nicotiflorin

Nictoflorin (incorr

4H-1-Benzopyran-4-one,3-[[6-O-(6-deoxy-a-L-Mannopyranosyl)-b-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-

3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside

KaeMpferol-3-O-rutinosid, froM CarthaMus tinctorius

Kaempferol-3-O-rutinosid

Aempferol-3-O-rutinoside

NICOTIFLORIN

KAEMPFEROL-3-O-RUTINOSIDE

KAEMPFEROL-3-RUTINOSIDE

Kaempfeol-3-O-rutinoside

KAEMPFEROL-3-O-RUTINOSIDE WITH HPLC

KAEMPFEROL-3-RUTINOSIDE hplc

3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(4-hydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one

3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Kaempferol 3-rhamnoglucoside

Nicotoflorin

Kaempferol-3-O-rutinosid ,98%

3-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Nicotifiorin

Nicotiflorine

Nicotifloroside

Kaempferol-3-O-rutinosid, 98%, from Carthamus tinctorius L.

Kaempferol-3-O-rutinosid, ≥98.0%(HPLC)

Rutoside Trihydrate Impurity 2（Rutoside Trihydrate EP Impurity B）

Rutoside Trihydrate EP Impurity B

Nicotiflorin (Kaempferol-3-O-beta-Rutinoside)

Nictoflorin

Kaempferol-3-O-beta-rutinoside

Rutoside EP Impurity B

4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-

Kaempferol 3-O-β -Rutinoside (Nicotiflorin)

Kaempferol 3-O-beta -Rutinoside (Nicotiflorin)

Kaempferol 3-O-β -rutinoside

5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

Kaempferol 3-rutinoside-RM

Rutoside Trihydrate EP Impurity B (Kaempferol-3-O-Beta-Rutinoside)

Kaempferol 3-O-b -Rutinoside (Nicotiflorin)

Kaempferol 3-<i>O</i>-β -rutinoside

Nicotiflorin (Kaempferol-3-O-rutinoside)

17650-84-9

Tetra-substituted Flavones

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract