Acacetin

ChemicalBook > CAS DataBase List > Acacetin

Product Name: Acacetin
CAS No.: 480-44-4
Chemical Name: Acacetin
Synonyms: Abietic;acacetine;5,7-dihydroxy-4’-methoxy-flavon;ACACETIN;LY 064233;NSC 76061;Linarisenin;LINARIGENIN;ACACETIN hplc;Acacetin, >98%
CBNumber: CB9316535
Molecular Formula: C16H12O5
Formula Weight: 284.26
MOL File: 480-44-4.mol

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Acacetin Property

Melting point:: 260-265 °C(lit.)
Boiling point:: 346.76°C (rough estimate)
Density: 1.2160 (rough estimate)
refractive index: 1.6200 (estimate)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Very Slightly, Heated)
form: Solid
pka: 6.51±0.40(Predicted)
color: Light Yellow to Green-Yellow to Dark Yellow
λmax: 335nm(EtOH)(lit.)
Merck: 14,13
BRN: 277879
InChIKey: DANYIYRPLHHOCZ-UHFFFAOYSA-N
LogP: 2.443 (est)
CAS DataBase Reference: 480-44-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: DJ3002000
F: 3-8-10
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89482
Product name: Acacetin
Purity: phyproof? Reference Substance
Packaging: 20mg
Price: $146.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 49975
Product name: Acacetin
Purity: analytical standard
Packaging: 10mg
Price: $247
Updated: 2022/05/15

TCI Chemical

Product number: A3013
Product name: Acacetin
Purity: >98.0%(GC)
Packaging: 25mg
Price: $173
Updated: 2024/03/01

TCI Chemical

Product number: A3013
Product name: Acacetin
Purity: >98.0%(GC)
Packaging: 100mg
Price: $344
Updated: 2024/03/01

Cayman Chemical

Product number: 20827
Product name: Acacetin
Purity: ≥98%
Packaging: 50mg
Price: $121
Updated: 2024/03/01

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Acacetin Chemical Properties,Usage,Production

Description

Acacetin is an O-methylated flavone found in various plants. It is reported to demonstrate spasmolytic, antinociceptive, anti-inflammatory, and antioxidant activity in various research models.

Chemical Properties

Yellow Solid

Uses

VEGF expression inhibitor and tumor angiogenesis. A flavonoid with antiaggregatory activity in human blood.

Definition

ChEBI: A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 6497, 1990 DOI: 10.1016/S0040-4039(00)97100-4

General Description

Acacetin belongs to the category of naturally occurring plant pigments called flavonoids found in vascular plants. It was first reported to be extracted from the leaves of Robinia pseuducacia. It has been used as an active component of traditional Chinese medicine Xuelianhua.

Biochem/physiol Actions

Acacetin has been noted to exhibit anti-peroxidative, anti-inflammatory, and anti-plasmodial properties. It has been posited to prevent the proliferation of Hep G2 cells, thereby causing cell apoptosis and subsequent anti-cancer action. It has antiarrhythmic properties and can be used in the treatment of Atrial fibrillation.

Enzyme inhibitor

This naturally occurring flavone (FW = 286.27 g/mol; CAS 480-44-4), also known as 5,7-dihydroxy-4’-methoxyflavone and 7-O-methylapigenin, and systematically named as 5,7-dihydroxy-2-(4-methoxyphenyl)-chromen-4- one, from the black locust Robinia pseudoacacia is the aglycon of linarin and acaciin and is biosynthesized by apigenin 4'-O-methyltransferase from S-adenosyl-methionine and 5,7,4’-trihydroxyflavone (apigenin), yielding Sadenosylhomocysteine and acacetin. The chemical synthesis of acacetin was accomplished by Robert Robinson, who was awarded the 1947 Nobel Prize in Chemistry for his work on alkaloids and organic synthesis. Target(s): glutathione S-transferase; xanthine oxidase, Ki = 0.11 μM; CYP1A; CYP1B1; glutathione-disulfide reductase; DNA topoisomerase I; [myosin light-chain] kinase; and protein-tyrosine kinase, or non-specific protein-tyrosine kinase.

Acacetin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Acacetin manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Acacetin 480-44-4
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-05

ANHUI WITOP BIOTECH CO., LTD

Product: Acacetin 480-44-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10 tons
Release date: 2021-03-19

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Acacetin 480-44-4
Price: US $725.00/kg
Min. Order: 1kg
Purity: 98% HPLC
Supply Ability: 20 tons
Release date: 2022-10-20

480-44-4, AcacetinRelated Search:

CETYL PALMITATE 1-Hydroxyethylidene-1,1-diphosphonic acid Triclosan Solvent Red 43 p-Anisidine Chrysin p-Anisaldehyde Anisole (Trifluoromethoxy)benzene (E,E)-Farnesol 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE 5,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE 3,7,3',4'-TETRAMETHYLGOSSYPETIN QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE ARTEMISININ TAMARIXETIN KAEMPFEROL-3,7,4'-TRIMETHYL ETHER

5,7-DIHYDROXY-4'-METHOXYFLAVONE

LINARIGENIN

METHYL-4'-APIGENIN

ACACETIN

5,7-dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone

Abietic

ACACETIN(METHYL-4'-APIGENIN)(RG)

ACACETIN WITH HPLC

4'-O-Methylapigenin

5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Linarisenin

Acacetin,5,7-Dihydroxy-4′-methoxyflavone

5,7-DIHYDROXY-2-(4-METHOXYPHENOL)-1-BENZOPYRAN-4-ONE

1-BENZOPYRAN-4-ONE,5,7-DIHYDROXY-2-(4-METHOXYPHENOL)-

2-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one

apisenin4’-methylether

buddleoflavonol

ACACETIN hplc

Acacetin 480-44-4

large stock Acacetin 480-44-4

7-hydroxy-2-(4-methoxyphenyl)-4-oxo-1-benzopyran-5-olate

Acacetin, >98%

LY 064233

NSC 76061

ACACETIN >= 97.0% (HPLC)

5,7-dihydroxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-on

5,7-dihydroxy-4’-methoxy-flavon

5,7-dioxy-4’-methoxyflavone

acacetine

5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen

Acacetin, 98%, From Acacia farnesiana (L.) Willd.

4'-Methoxyapigenin

4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)-

O sand and paxil

4'-methoxy-5,7-dihydroxy flavone

Acacetin Powder

480-44-4

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