4'-Hydroxy-3'-methylacetophenone

Product Name: 4'-Hydroxy-3'-methylacetophenone
CAS No.: 876-02-8
Chemical Name: 4'-Hydroxy-3'-methylacetophenone
Synonyms: 4-HYDROXY-3-METHYLACETOPHENONE;4'-Hydroxy-3'-methyl;4-ACETYL-2-METHYLPHENOL;TrichIoroacetyI chIorine;4'-Hydroxy-3'-methylacetophenone;3'-Methyl-4'-Hydroxy Acetophenone;4'-Hydroxy-3'-methylacetophenone>1-(4-HYDROXY-3-METHYLPHENYL)ETHANONE;4’-Hydroxy-3’-Methyl acetophenone99%;4'-Hydroxy-3'-methylacetophenone, 95%
CBNumber: CB7468317
Molecular Formula: C9H10O2
Formula Weight: 150.17
MOL File: 876-02-8.mol

More

Less

4'-Hydroxy-3'-methylacetophenone Property

Melting point:: 107-109 °C(lit.)
Boiling point:: 175°C 1mm
Density: 1.0858 (rough estimate)
refractive index: 1.5180 (estimate)
Flash point:: 175°C/1mm
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 8.52±0.18(Predicted)
color: Off-White to Pale Beige
BRN: 2041839
Stability:: Hygroscopic
LogP: 1.395 (est)
CAS DataBase Reference: 876-02-8(CAS DataBase Reference)
NIST Chemistry Reference: 4-Hydroxy-3-methylacetophenone(876-02-8)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 36/37/39-26-22-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29143990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H38004
Product name: 4′-Hydroxy-3′-methylacetophenone
Purity: 97%
Packaging: 5g
Price: $30.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: H38004
Product name: 4′-Hydroxy-3′-methylacetophenone
Purity: 97%
Packaging: 25g
Price: $56.5
Updated: 2023/01/07

TCI Chemical

Product number: H0791
Product name: 4'-Hydroxy-3'-methylacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: H0791
Product name: 4'-Hydroxy-3'-methylacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $108
Updated: 2025/07/31

TRC

Product number: H946870
Product name: 4''-Hydroxy-3''-methylacetophenone
Packaging: 5g
Price: $90
Updated: 2021/12/16

More

Less

4'-Hydroxy-3'-methylacetophenone Chemical Properties,Usage,Production

Chemical Properties

white to light beige crystalline powder or

Uses

4''-Hydroxy-3''-methylacetophenone is used in the synthesis of 3-De(hydroxymethyl)-3-methyl Salmeterol (D230650), which is an impurity of β2-Adrenergic agonist Salmeterol (S090100).

Definition

ChEBI: 4-hydroxy-3-methylacetophenone is a monohydroxyacetophenone that is acetophenone carrying methyl and hydroxy groups at positions 3 and 4, respectively. It has a role as a volatile oil component and an insect attractant. It is a monohydroxyacetophenone, a member of phenols and a hydroxytoluene. It is functionally related to an acetophenone.

Preparation

Preparation by dealkylation of 4-hydroxy-5-methyl-2-iso-propylacetophenone with aluminium chloride in chloro-benzene at 50° (53%).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008

4'-Hydroxy-3'-methylacetophenone Preparation Products And Raw materials

Raw materials

Dichloroacetyl chloride Chlorine

Preparation Products

Chlorpyrifos,E.C. Chlorpyrifos

More

Less

4'-Hydroxy-3'-methylacetophenone Suppliers

Americas 1 Belgium 2 China 190 Europe 3 France 1 Germany 5 India 19 Japan 3 Switzerland 1 The Netherlands 1 United Kingdom 11 United States 28 Global 265

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 0512-62857507
Fax: +86-512-62857507
Email: sales@sinorarechem.com
Country: China
ProdList: 991
Advantage: 58

Nantong Xiaochang Pharmaceutical Trading Co., Ltd.

Tel: 0513-82104991 18912868361
Fax: QQ1907456386
Email: sales11@btcpharm.com
Country: China
ProdList: 1250
Advantage: 58

Creasyn Finechem(Tianjin) Co., Ltd.

Tel: 022-83946278 13820503911
Fax: 022-83945176
Email: sales@creasyn.com
Country: China
ProdList: 957
Advantage: 68

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

More

Less

View Lastest Price from 4'-Hydroxy-3'-methylacetophenone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-(4-Hydroxy-3-methylphenyl)ethanone 876-02-8
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Shaanxi Dideu New Materials Co. Ltd

Product: 4'-Hydroxy-3'-methylacetophenone 876-02-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-07

Shaanxi Dideu New Materials Co. Ltd

Product: 4'-Hydroxy-3'-methylacetophenone 876-02-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-26

876-02-8, 4'-Hydroxy-3'-methylacetophenoneRelated Search:

4'-Hydroxyacetophenone 3,5-Dihydroxyacetophenone 3'-Methylacetophenone 4-Nitroacetophenone 2',6'-Dihydroxyacetophenone 4'-(Trifluoromethyl)acetophenone 3'-Hydroxyacetophenone 3-Nitroacetophenone 3'-(Trifluoromethyl)acetophenone 2-HYDROXYACETOPHENONE Acetophenone CHLOROPHOSPHONAZO III 2'-Hydroxyacetophenone 3-Methoxyacetophenone 4'-Methylacetophenone 2,4-Dihydroxyacetophenone PIPERACETAZINE (250 MG) 2',4'-Dichloroacetophenone

Ethanone, 1-(4-hydroxy-3-methylphenyl)-

1-(4-HYDROXY-3-METHYLPHENYL)ETHAN-1-ONE

1-(4-HYDROXY-3-METHYLPHENYL)ETHANONE

4-ACETYL-2-METHYLPHENOL

4-HYDROXY-3-METHYLACETOPHENONE

3'-Methyl-4'-Hydroxy Acetophenone

4-hydroxy-3-methylphenyl methyl ketone

TrichIoroacetyI chIorine

4'-Hydroxy-3'-methylacetophenone, 99.5+%

4'-Hydroxy-3'-methyl

4'-Hydroxy-3'-methylacetophenone&gt

4’-Hydroxy-3’-Methyl acetophenone99%

4'-Hydroxy-3'-methylacetophenone

4'-Hydroxy-3'-methylacetophenone, 95%

4′-Hydroxy-3′-methylacetophenone, CAS 876-02-8

876-02-8

976-02-8

HOC6H3CH3COCH3

KETONE

Organic Building Blocks

Ketones

C9

Carbonyl Compounds

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Aromatic Acetophenones & Derivatives (substituted)

Benzene series

Benzene derivatives

C9

Carbonyl Compounds

Ketones