3'-Hydroxyacetophenone
- Product Name
- 3'-Hydroxyacetophenone
- CAS No.
- 121-71-1
- Chemical Name
- 3'-Hydroxyacetophenone
- Synonyms
- 3-HYDROXYACETOPHENONE;1-(3-Hydroxyphenyl)ethan-1-one;Ethanone, 1-(3-hydroxyphenyl)-;3-ACETYLPHENOL;3-Hydroxyacetophenon;M-HYDROXYACETOPHENONE;3-HAP;3-ACETOPHENOL;m-Acetylphenol;META-HYDROXYACETOPHENONE
- CBNumber
- CB1407158
- Molecular Formula
- C8H8O2
- Formula Weight
- 136.15
- MOL File
- 121-71-1.mol
3'-Hydroxyacetophenone Property
- Melting point:
- 90-95 °C(lit.)
- Boiling point:
- 296 °C(lit.)
- Density
- 1.1 g/mL at 25 °C(lit.)
- vapor pressure
- 0.022Pa at 25℃
- refractive index
- 1,534
- Flash point:
- 296°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 22g/l
- form
- Crystalline Powder
- pka
- 9.19(at 25℃)
- color
- Beige-brown
- Water Solubility
- Soluble in alcohol. Insoluble in water.
- BRN
- 2040676
- InChIKey
- LUJMEECXHPYQOF-UHFFFAOYSA-N
- LogP
- 1.144 at 25℃
- CAS DataBase Reference
- 121-71-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-(3-hydroxyphenyl)-(121-71-1)
- EPA Substance Registry System
- Ethanone, 1-(3-hydroxyphenyl)- (121-71-1)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 22-24/25-37/39-26-36
- WGK Germany
- 3
- Hazard Note
- Harmful/Irritant
- TSCA
- Yes
- HS Code
- 29143990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 328103
- Product name
- 3′-Hydroxyacetophenone
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $26.8
- Updated
- 2025/07/31
- Product number
- 328103
- Product name
- 3′-Hydroxyacetophenone
- Purity
- ≥99%
- Packaging
- 25g
- Price
- $42.9
- Updated
- 2025/07/31
- Product number
- A0104
- Product name
- 3'-Hydroxyacetophenone
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- A0104
- Product name
- 3'-Hydroxyacetophenone
- Purity
- >98.0%(GC)(T)
- Packaging
- 500g
- Price
- $271
- Updated
- 2025/07/31
- Product number
- H18801
- Product name
- 3′-Hydroxyacetophenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $50.25
- Updated
- 2025/07/31
3'-Hydroxyacetophenone Chemical Properties,Usage,Production
Description
3’-Hydroxyacetophenone is a chemical compound and it is a component of castoreum, the exudate from the castor sacs of the mature beaver. It is used in the synthesis and preparation of chalcones and flavonoids as anti-tuberculosis agents, as well as antileishmanial chaocones.
Chemical Properties
beige-brown crystalline powder
Uses
Useful in the preparation of chalcones, flavonoids, and phenylephrine. It is an active component of castoreum, which is used as a tincture in some perfumes and as a food additive.
Uses
3?Hydroxyacetophenone is used in the preparation of chalcones and flavonoids, which finds application as an anti-tuberculosis agent and antileishmanial chaocones. It is also involved in the preparation of phenylephrine. Further, it is an active component of castoreum, which is used as a tincture in some perfumes and as a food additive.
Uses
3’Hydroxyacetophenone is a chemical reagent used in the synthesis and preparation of chalcones and flavonoids as anti-tuberculosis agents, as well as antileishmanial chaocones.
Preparation
Preparation by diazotization of 3-aminoacetophenone, followed by hydrolysis of the obtained diazonium salt (78–82%).
General Description
3′-Hydroxyacetophenone is an hydroxy-substituted alkyl phenyl ketone.
Flammability and Explosibility
Non flammable
Synthesis
14452-30-3
121-71-1
General procedure for the synthesis of 3-hydroxyacetophenone from 3-iodoacetophenone: 3-iodoacetophenone (1.0 mmol), CuCl? (13.4 mg, 0.1 mmol), KOH (336 mg, 6.0 mmol), ethylene glycol (12 μL, 0.2 mmol), and a solvent mixture of DMSO/H?O were sequentially added to the test tube fitted with a magnetic stirrer ( 1.0 mL/0.5 mL). The reaction mixture was placed in a preheated 120 °C oil bath under argon protection and stirred for 24 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted by partitioning with 5% HCl aqueous solution and ethyl acetate. The organic phase was washed sequentially with water and saturated saline, dried over anhydrous MgSO? and concentrated under reduced pressure to remove the solvent. The crude product was further purified by column chromatography (eluent: EtOAc/hexane) to afford the target product 3-hydroxyacetophenone.
References
[1] Journal of the American Chemical Society, 2016, vol. 138, # 41, p. 13493 - 13496
[2] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 12, p. 2833 - 2840
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 315 - 318
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 315 - 318
[5] Synlett, 2016, vol. 27, # 12, p. 1814 - 1819
3'-Hydroxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3'-Hydroxyacetophenone manufacturers
- Product
- 3'-Hydroxyacetophenone(3-HAP) 121-71-1
- Price
- US $70.00/kg
- Min. Order
- 800kg
- Purity
- 99%
- Supply Ability
- 50 ton per month
- Release date
- 2025-08-27
- Product
- 3'-Hydroxyacetophenone 121-71-1
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-22
- Product
- 3'-Hydroxyacetophenone 121-71-1
- Price
- US $100.00-80.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000000
- Release date
- 2025-03-06