ChemicalBook > CAS DataBase List > 4'-Hydroxy-3'-methylacetophenone

4'-Hydroxy-3'-methylacetophenone

Product Name
4'-Hydroxy-3'-methylacetophenone
CAS No.
876-02-8
Chemical Name
4'-Hydroxy-3'-methylacetophenone
Synonyms
4-HYDROXY-3-METHYLACETOPHENONE;4'-Hydroxy-3'-methyl;4-ACETYL-2-METHYLPHENOL;TrichIoroacetyI chIorine;4'-HYDROXY-3'-METHYLACETOPHENONE;4'-Hydroxy-3'-methylacetophenone;3'-Methyl-4'-Hydroxy Acetophenone;4'-Hydroxy-3'-methylacetophenone>1-(4-HYDROXY-3-METHYLPHENYL)ETHANONE;4’-Hydroxy-3’-Methyl acetophenone99%
CBNumber
CB7468317
Molecular Formula
C9H10O2
Formula Weight
150.17
MOL File
876-02-8.mol
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4'-Hydroxy-3'-methylacetophenone Property

Melting point:
107-109 °C(lit.)
Boiling point:
175°C 1mm
Density 
1.0858 (rough estimate)
refractive index 
1.5180 (estimate)
Flash point:
175°C/1mm
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
8.52±0.18(Predicted)
color 
Off-White to Pale Beige
BRN 
2041839
Stability:
Hygroscopic
LogP
1.395 (est)
CAS DataBase Reference
876-02-8(CAS DataBase Reference)
NIST Chemistry Reference
4-Hydroxy-3-methylacetophenone(876-02-8)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
36/37/39-26-22-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29143990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H38004
Product name
4′-Hydroxy-3′-methylacetophenone
Purity
97%
Packaging
5g
Price
$30.1
Updated
2023/06/20
Sigma-Aldrich
Product number
H38004
Product name
4′-Hydroxy-3′-methylacetophenone
Purity
97%
Packaging
25g
Price
$56.5
Updated
2023/01/07
TCI Chemical
Product number
H0791
Product name
4'-Hydroxy-3'-methylacetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
H0791
Product name
4'-Hydroxy-3'-methylacetophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$108
Updated
2024/03/01
Alfa Aesar
Product number
A18540
Product name
4'-Hydroxy-3'-methylacetophenone, 98%
Packaging
1g
Price
$26.65
Updated
2024/03/01
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4'-Hydroxy-3'-methylacetophenone Chemical Properties,Usage,Production

Chemical Properties

white to light beige crystalline powder or

Uses

4''-Hydroxy-3''-methylacetophenone is used in the synthesis of 3-De(hydroxymethyl)-3-methyl Salmeterol (D230650), which is an impurity of β2-Adrenergic agonist Salmeterol (S090100).

Definition

ChEBI: 4-hydroxy-3-methylacetophenone is a monohydroxyacetophenone that is acetophenone carrying methyl and hydroxy groups at positions 3 and 4, respectively. It has a role as a volatile oil component and an insect attractant. It is a monohydroxyacetophenone, a member of phenols and a hydroxytoluene. It is functionally related to an acetophenone.

Preparation

Preparation by dealkylation of 4-hydroxy-5-methyl-2-iso-propylacetophenone with aluminium chloride in chloro-benzene at 50° (53%).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008

4'-Hydroxy-3'-methylacetophenone Preparation Products And Raw materials

Raw materials

Dichloroacetyl chloride Chlorine

Preparation Products

Chlorpyrifos,E.C. Chlorpyrifos
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4'-Hydroxy-3'-methylacetophenone Suppliers

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View Lastest Price from 4'-Hydroxy-3'-methylacetophenone manufacturers

Honest Joy Holdings Limited
Product
4'-Hydroxy-3'-methylacetophenone 876-02-8
Price
US $0.00/KG
Min. Order
1KG
Purity
98.6%
Supply Ability
100 tons
Release date
2022-02-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
4"-Hydroxy-3"-methylacetophenone 876-02-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4'-Hydroxy-3'-methylacetophenone 876-02-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-05-24

876-02-8, 4'-Hydroxy-3'-methylacetophenoneRelated Search:

4'-Hydroxyacetophenone 3,5-Dihydroxyacetophenone 3'-Methylacetophenone 4-Nitroacetophenone 2',6'-Dihydroxyacetophenone 4'-(Trifluoromethyl)acetophenone 3'-Hydroxyacetophenone 3-Nitroacetophenone 3'-(Trifluoromethyl)acetophenone 2-HYDROXYACETOPHENONE Acetophenone CHLOROPHOSPHONAZO III 2'-Hydroxyacetophenone 3-Methoxyacetophenone 4'-Methylacetophenone 2,4-Dihydroxyacetophenone PIPERACETAZINE (250 MG) 2',4'-Dichloroacetophenone

  • Ethanone, 1-(4-hydroxy-3-methylphenyl)-
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  • 4-HYDROXY-3-METHYLACETOPHENONE
  • 3'-Methyl-4'-Hydroxy Acetophenone
  • 4-hydroxy-3-methylphenyl methyl ketone
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  • 4'-Hydroxy-3'-methylacetophenone, 99.5+%
  • 4'-Hydroxy-3'-methyl
  • 4'-Hydroxy-3'-methylacetophenone&gt
  • 4’-Hydroxy-3’-Methyl acetophenone99%
  • 4'-Hydroxy-3'-methylacetophenone
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  • KETONE
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  • C9
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  • Organic Building Blocks
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