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STERIGMATOCYSTIN

Product Name
STERIGMATOCYSTIN
CAS No.
10048-13-2
Chemical Name
STERIGMATOCYSTIN
Synonyms
NSC 204985;NSC 201423;,(3ar-cis)-;petiolubicin;STERIGMATOCYSTIN;STERIGMATOCYSTINE;Sterigmatocystin,98%;Sertindole Impurity 14;STERIGMATOCYSTIN USP/EP/BP;Sterigmatocystin solution
CBNumber
CB1475014
Molecular Formula
C18H12O6
Formula Weight
324.28
MOL File
10048-13-2.mol
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STERIGMATOCYSTIN Property

Melting point:
249-251℃
Boiling point:
382.63°C (rough estimate)
Density 
1.2842 (rough estimate)
refractive index 
1.4800 (estimate)
Flash point:
6℃
storage temp. 
2-8°C
solubility 
Acetone: 5 mg/ml
form 
powder
pka
6.92±0.20(Predicted)
color 
yellow
BRN 
53259
LogP
3.169 (est)
CAS DataBase Reference
10048-13-2
IARC
2B (Vol. 10, Sup 7) 1987
EPA Substance Registry System
Sterigmatocystin (10048-13-2)
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Safety

Hazard Codes 
T,Xn,F
Risk Statements 
25-40-36-20/21/22-11
Safety Statements 
36/37-45-16
RIDADR 
UN 3462 6.1/PG 3
WGK Germany 
3
RTECS 
LV1750000
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29329990
Hazardous Substances Data
10048-13-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
32986
Product name
Sterigmatocystin solution
Purity
50μg/mL in acetonitrile, analytical standard
Packaging
1ml
Price
$421
Updated
2024/03/01
Sigma-Aldrich
Product number
32609
Product name
Sterigmatocystin
Purity
reference material
Packaging
5mg
Price
$1310
Updated
2024/03/01
Cayman Chemical
Product number
11441
Product name
Sterigmatocystin
Purity
≥98%
Packaging
500μg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
11441
Product name
Sterigmatocystin
Purity
≥98%
Packaging
1mg
Price
$53
Updated
2024/03/01
Sigma-Aldrich
Product number
S3255
Product name
Sterigmatocystin
Purity
powder, ≥98% (TLC)
Packaging
1mg
Price
$80.8
Updated
2024/03/01
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STERIGMATOCYSTIN Chemical Properties,Usage,Production

Description

Sterigmatocystin is a mycotoxin that has been found in Aspergillus. It is lethal to rats (LD50 = 60 mg/kg) and chick embryos (LD50s = 5-7 μg/embryo). Sterigmatocystin (100 and 1,000 ppb in drinking water) induces gastritis, as well as intestinal polyp formation and metaplasia in aged Mongolian gerbils. It induces formation of lung and liver adenomas and malignant lymphomas in newborn mice.

Chemical Properties

yellow needles or powder

Uses

Sterigmatocystin is a carcinogenic mycotoxin that is struturally related to Aflatoxin. Sterigmatocystin has been shown to inhibit RNA synthesis in rat liver nuclei.

Uses

Sterigmatocystin is a xanthone produced by several species of Aspergillus, isolated by a number of research groups in the 1950s as a mycotoxin associated with food and grain contamination. Sterigmatocystin is structurally related to the aflatoxins and, while it is considered to be mutagenic, teratogenic and carcinogenic, it is less widespread and potent than the aflatoxins. Sterigmatocystin, in the presence of microsomes, covalently binds to DNA. It uncouples oxidative phosphorylation but, unlike the aflatoxins, does not induce mitochondrial swelling or hinder Ca2+-induced swelling of mitochondria. Sterigmatocystin also inhibits acyl-CoA:cholesterol acyltransferase (ACAT) with selectivity for the ACAT2 isoenzyme.

Definition

ChEBI: An organic heteropentacyclic compound whose skeleton comprises a xanthene ring system ortho-fused to a dihydrofuranofuran moiety. The parent of the class of sterigmatocystins.

Hazard

Possible carcinogen; tumorigen; poison; mutagen; causes necrosis of the liver and kidney, and an inhibitory effect on orotic acid incorporation into nuclear RNA.

Biochem/physiol Actions

Initiates lung and liver tumors under experimental conditions.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

It crystallises from amyl acetate, Me2CO or EtOH and sublimes in vacuo. It has UV max at 208, 235, 249 and 329nm (log  4.28, 4.39, 4.44 and 4.12). [UV: Bullock et al. J Chem Soc 4179, 1962, UV, IR: Holker & Mulheirn J Chem Soc, Chem Commun 1576, 1576 1968, Birkinshaw & Hammady Biochem J 65 162 1957.] This mycotoxin induces bone marrow changes in mice [Curry et al. Mutation Res 137 111 1984]. [Beilstein 19/10 V 575.]

STERIGMATOCYSTIN Preparation Products And Raw materials

Raw materials

Preparation Products

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STERIGMATOCYSTIN Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
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View Lastest Price from STERIGMATOCYSTIN manufacturers

Career Henan Chemical Co
Product
STERIGMATOCYSTIN 10048-13-2
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

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