Asiatic acid
- Product Name
- Asiatic acid
- CAS No.
- 464-92-6
- Chemical Name
- Asiatic acid
- Synonyms
- 2,3,23-TRIHYDROXY-12-URSEN-28-OIC ACID;NSC 166063;ASIATIC ACID;Asiantic acid;ASIATICA ACID;ASIATIC ACID(P);DaMMarolic acid;Asiatic acid-RM;Asiatic Acid >Snow oxalic acid
- CBNumber
- CB5109340
- Molecular Formula
- C30H48O5
- Formula Weight
- 488.7
- MOL File
- 464-92-6.mol
Asiatic acid Property
- Melting point:
- 325-330 °C(lit.)
- Boiling point:
- 609.4±55.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- RTECS
- YU9580000
- storage temp.
- 2-8°C
- solubility
- methanol: soluble1mg/mL, clear, colorless
- form
- powder
- pka
- 4.66±0.70(Predicted)
- color
- white
- biological source
- Centella asiatica
- Water Solubility
- Soluble in dimethyl sulfoxide, ethanol and dimethylformamide. Sparingly soluble in water
- InChIKey
- JXSVIVRDWWRQRT-UYDOISQJSA-N
- LogP
- 5.748 (est)
- CAS DataBase Reference
- 464-92-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- HS Code
- 29181990
- Hazardous Substances Data
- 464-92-6(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- 89773
- Product name
- Asiatic acid
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $460
- Updated
- 2025/07/31
- Product number
- 546712
- Product name
- Asiatic acid
- Purity
- 97%
- Packaging
- 500mg
- Price
- $267.9
- Updated
- 2025/07/31
- Product number
- A2475
- Product name
- Asiatic Acid
- Packaging
- 200MG
- Price
- $95
- Updated
- 2025/07/31
- Product number
- 11818
- Product name
- Asiatic Acid
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $41
- Updated
- 2024/03/01
- Product number
- 11818
- Product name
- Asiatic Acid
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $183
- Updated
- 2024/03/01
Asiatic acid Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from the whole grass of Centella asiatica (Centella asiatica), a plant of the genus Leiogangen, family Umbelliferae.
Uses
wound healing, experimental carcinogen
Uses
Asiatic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Asiatic Acid is a neuroprotectant and induces of apoptosis in HepG2 human hepatoma cells.
Uses
Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. It is a starting material for asiatic acid derivative synthesis for use as anticancer agents, glycogen phosphorylase inhibitors and and hepatoprotectants.
Definition
ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). It is isolated from Symplocos lancifolia and Vateria indica and exhibits anti-angiogenic activity.
General Description
Asiatic acid is a naturally occurring pentacyclic triterpenoid, obtained from Centella asiatica.
Biochem/physiol Actions
Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties.
Synthesis
16830-15-2
464-92-6
1) 1 g of (2α,3β,4α)-3,4-dihydroxy-6-(hydroxymethyl)-5-((3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-hexamethyl- Eicosanoid-4a-carboxylic acid ester (asiaticoside), 4.3×10^-2 mol sodium dodecyl sulfate and 0.02 mol NaOH were mixed, water was added to 1 L, and stirred until completely dissolved to obtain a mixed solution. The hydrolysis reaction was carried out at room temperature (25°C) and atmospheric pressure (1 atm) for 15 min to obtain the hydrolysate.2) The pH of the hydrolysate was adjusted to 5.0 with 1 M HCl solution and allowed to stand for 30 min, followed by filtration and collection of the precipitate.3) The precipitate was dissolved in 70% (v/v) aqueous ethanol at a ratio of 1 g:30 mL and filtered to remove insoluble matter. Crystallization was carried out by adding 16 times the volume of distilled water to the filtrate and allowed to stand overnight for complete crystallization. The crystallized product was collected by filtration and dried to constant weight in a vacuum drying oven at 40°C to obtain cumaric acid white crystals of 0.445 g. The product was analyzed by high-performance liquid chromatography (HPLC) with a purity of 95.8% and a yield of 93.08%.
target
TNF-α | IFN-γ | IL Receptor | Caspase | p21 | NOS | NADPH-oxidase | NO | HMG-CoA reductase | COX
References
[1] Patent: CN106349319, 2017, A. Location in patent: Paragraph 0017-0032
[2] Patent: WO2009/89365, 2009, A2. Location in patent: Page/Page column 6-7
[3] Steroids, 2015, vol. 96, p. 44 - 49
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4500 - 4504
[5] RSC Advances, 2016, vol. 6, # 67, p. 62890 - 62906
Asiatic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Asiatic acid Suppliers
- Tel
- 029-029-86629612 18202932191
- sales3@pioneerbiotech.com
- Country
- China
- ProdList
- 300
- Advantage
- 55
- Tel
- 025-84430028 13815430202
- sale02@cqherb.com
- Country
- China
- ProdList
- 294
- Advantage
- 59
- Tel
- 0773-0773-8280552 18978691595
- Fax
- 0773-8280552
- 935960@qq.com
- Country
- China
- ProdList
- 36
- Advantage
- 58
- Tel
- 18805194892
- 2727751293@qq.com
- Country
- China
- ProdList
- 170
- Advantage
- 58
- Tel
- 180-62205282 18062205282
- turbo_cq@163.com
- Country
- China
- ProdList
- 34
- Advantage
- 58
- Tel
- 15829065593
- hty15829065593@qq.com
- Country
- China
- ProdList
- 157
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
View Lastest Price from Asiatic acid manufacturers
- Product
- Asiatic acid 464-92-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-04-28
- Product
- Asiatic acid 464-92-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-10
- Product
- Asiatic Acid 464-92-6
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-12-09