5-chloro-2,4-dihydroxybenzaldehyde
- Product Name
- 5-chloro-2,4-dihydroxybenzaldehyde
- CAS No.
- 131088-02-3
- Chemical Name
- 5-chloro-2,4-dihydroxybenzaldehyde
- Synonyms
- 5-chloro-2,4-dihydroxybenzaldehyde;2,4 -dihydroxy-5-chlorobenzaldehyde;Benzaldehyde, 5-chloro-2,4-dihydroxy-;5-Chloro-2,4-dihydroxybenzaldehyde，97%
- CBNumber
- CB12561249
- Molecular Formula
- C7H5ClO3
- Formula Weight
- 172.57
- MOL File
- 131088-02-3.mol
5-chloro-2,4-dihydroxybenzaldehyde Property
- Melting point:
- 163-164 °C
- Boiling point:
- 332.8±22.0 °C(Predicted)
- Density
- 1.570±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.11±0.23(Predicted)
- Appearance
- White to pink Solid
- InChI
- InChI=1S/C7H5ClO3/c8-5-1-4(3-9)6(10)2-7(5)11/h1-3,10-11H
- InChIKey
- IPOSHVWRFQTHGK-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(Cl)=C(O)C=C1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5108CV
- Product name
- 5-Chloro-2,4-dihydroxybenzaldehyde
- Packaging
- 1g
- Price
- $107
- Updated
- 2021/12/16
- Product number
- CM248777
- Product name
- 5-Chloro-2,4-dihydroxybenzaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $343
- Updated
- 2021/12/16
- Product number
- CD12154585
- Product name
- 5-Chloro-2,4-dihydroxybenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $363
- Updated
- 2021/12/16
- Product number
- 131088023
- Product name
- 5-Chloro-2,4-dihydroxybenzaldehyde
- Packaging
- 1g
- Price
- $367
- Updated
- 2021/12/16
- Product number
- 60149
- Product name
- 5-chloro-2,4-dihydroxybenzaldehyde
- Purity
- >95%
- Packaging
- 5g
- Price
- $880
- Updated
- 2021/12/16
5-chloro-2,4-dihydroxybenzaldehyde Chemical Properties,Usage,Production
Synthesis
95-01-2
131088-02-3
General procedure for the synthesis of 5-chloro-2,4-dihydroxybenzaldehyde from 2,4-dihydroxybenzaldehyde: Sulfonyl chloride (14 mL, 171.2 mmol) was added slowly and dropwise to a solution of 2,4-dihydroxybenzaldehyde (20 g, 144.92 mmol) in ether (500 mL) at 0 °C and under argon protection. After the dropwise addition was completed, the reaction mixture was warmed to room temperature and stirring was continued for 30 minutes. Subsequently, the reaction mixture was poured into ice water to separate the organic layer. The organic layer was washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=90:10) to afford 5-chloro-2,4-dihydroxybenzaldehyde as an off-white solid (6.7 g, 26% yield, 97% purity by LC/MS). eSI-MS, m/z 170.9 [M-H]? ; elemental analysis consistent with C7H5ClO3; 1H NMR (DMSO-d6, 400 MHz): δ 11.39 (1H, s), 10.87 (1H, s), 9.98 (1H, s), 7.0 (1H, s), 6.58 (1H, s).
References
[1] Chemical Biology and Drug Design, 2015, vol. 86, # 5, p. 1030 - 1035
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 19, p. 3505 - 3508
[3] Chemical Communications, 2008, # 10, p. 1217 - 1219
[4] Heterocycles, 1997, vol. 45, # 7, p. 1345 - 1361
[5] Journal of the American Chemical Society, 2010, vol. 132, # 26, p. 8828 - 8830
5-chloro-2,4-dihydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
5-chloro-2,4-dihydroxybenzaldehyde Suppliers
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View Lastest Price from 5-chloro-2,4-dihydroxybenzaldehyde manufacturers
- Product
- 5-chloro-2,4-dihydroxybenzaldehyde 131088-02-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-08