ChemicalBook > CAS DataBase List > ITF2357

ITF2357

Product Name: ITF2357
CAS No.: 732302-99-7
Chemical Name: ITF2357
Synonyms: ITF2357;CS-1443;ITF2357 (Givinostat);Givinostat(HCl hydrate);Givinostat Hydrochloride Hydrate;Givinostat (ITF2357) 732302-99-7;ITF2357 hydrochloride monohydrate;Givinostat (ITF2357) HCl monohydrate;Gavinostat hydrochloride monohydrate;Givinostat HCl monohydrate (ITF-2357
CBNumber: CB12561481
Molecular Formula: C24H30ClN3O5
Formula Weight: 475.9651
MOL File: 732302-99-7.mol

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ITF2357 Property

storage temp.: -20°C
solubility: ≥23.8 mg/mL in DMSO; insoluble in EtOH; ≥2.9 mg/mL in H2O with gentle warming and ultrasonic
form: powder
color: white to beige
InChIKey: FKGKZBBDJSKCIS-UHFFFAOYSA-N
SMILES: C(OCC1=CC=C2C(=C1)C=CC(CN(CC)CC)=C2)(=O)NC1=CC=C(C(NO)=O)C=C1.[H]Cl.[H]O[H]
CAS DataBase Reference: 732302-99-7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1772
Product name: Givinostat hydrochloride hydrate
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $139.86
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1772
Product name: Givinostat hydrochloride hydrate
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $596
Updated: 2025/07/31

Cayman Chemical

Product number: 11045
Product name: ITF 2357
Purity: ≥98%
Packaging: 1mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 11045
Product name: ITF 2357
Purity: ≥98%
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 11045
Product name: ITF 2357
Purity: ≥98%
Packaging: 10mg
Price: $220
Updated: 2024/03/01

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ITF2357 Chemical Properties,Usage,Production

Uses

Givinostat Hydrochloride Hydrate is a potent inhibitor of HDAC with IC50?of 7.5-16 nM. It is used in the treatment of muscular dystrophy.

Uses

Givinostat hydrochloride hydrate has been used as a histone deacetylase inhibitor to test its effect on the human immunodeficiency virus reactivation in CD4⁺ T-cell model.

Biological Activity

itf2357, also known as givinostat, is a potent inhibitor of both class i and class ii histone deacetylase (hdac) as well as a potent inhibitor of hematopoietic colony formation by jakev617f-bearing progenitor cells from chronic myeloproliferative neoplasms in vitro. previous studies has shown that itf2357 induces apoptosis of multiple myeloma (mm) and acute myelogenous leukemia (aml) cells following induction of p21 and down-modulation of bcl-2 and mcl-1 proteins and inhibits the production of pro-inflammatory cytokines (such as il-1, il-6, tumor necrosis factor (tnf)-α and interferon (ifn)-γ) by peripheral blood mononuclear cells as well as the production of il-6 and vascular endothelium growth factor (vegf) by mesenchymal stromal cells.katia todoerti, valentina barbui, olga pedrini, marta linett, gianluca fossati, paolo mascagni, alessandro rambaldi, antonino neri, martino introna, luigia lombardi, and josee golay. pleiotropi anti-myeloma activity of itf2357: inhibition of interleukin-6 receptor signaling and repression of mir-19a and mir-19b. haematologica 2010; 95(2): 260-269

Biochem/physiol Actions

Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. Givinostat posseses a very promising activity profile in multiple myeloma and acute myelogenous leukemia in vitro and in vivo. Givinostat also has anti-inflammatory activity and inhibits the secretion of the tumor necrosis factor-alpha (TNF-α), IL-1, and IL-6. Givinostat has been in multiple Phase 2 studies for both inflammatory diseases (Duchenne Muscular Dystrophy , Juvenile arthritis, Polycythemia Vera) and blood cancers (myelomas and lymphomas).

in vivo

Givinostat (ITF2357) at 10 mg/kg is used as a positive control and, as expected, reduced serum TNFα by 60%. Strikingly, pretreatment of ITF3056 starting at 0.1 mg/kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg/kg), and blood is collected after 4 h. Similarly, when pretreated with lower doses of Givinostat (ITF2357) (1 or 5 mg/kg), there is a 22% reduction for 1 mg/kg and 40% for 5 mg/kg^[1].

target

HDAC

IC 50

hHDAC3: 157 nM (IC₅₀); hHDAC1: 198 nM (IC₅₀); hHDAC11: 292 nM (IC₅₀); hHDAC6: 315 nM (IC₅₀); hHDAC2: 325 nM (IC₅₀); hHDAC10: 340 nM (IC₅₀); hHDAC7: 524 nM (IC₅₀); hHDAC5: 532 nM (IC₅₀); hHDAC9: 541 nM (IC₅₀); hHDAC8: 854 nM (IC₅₀); hHDAC4: 1059 nM (IC₅₀); HD1-B: 7.5 nM (IC₅₀); HD1-A: 16 nM (IC₅₀); HD2: 10 nM (IC₅₀)

ITF2357 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ITF2357 manufacturers

Career Henan Chemical Co

Product: Givinostat 732302-99-7
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

732302-99-7, ITF2357Related Search:

[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester AR-42 Panobinostat JNJ-26481585 Mocetinostat (MGCD0103) Vorinostat Entinostat

(6-((diethylamino)methyl)naphthalen-2-yl)methyl 4-(hydroxycarbamoyl)phenylcarbamate hydrochloride hydrate

ITF2357

ITF2357 (Givinostat)

N-[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester hydrochloride hydrate

Givinostat (hydrochloride monohydrate)

Givinostat Hydrochloride Hydrate

Givinostat (ITF2357) HCl monohydrate

Givinostat(HCl hydrate)

CS-1443

Givinostat (ITF2357) hydrochloride monohydrate

ITF2357 hydrochloride monohydrate

Gavinostat hydrochloride monohydrate

Givinostat HCl monohydrate (ITF-2357

ITF2357 ITF-2357 Givinostat hydrochloride monohydrate

Givinostat (ITF2357) 732302-99-7

Givinostat hydrochloride,ITF-2357 hydrochloride,Givinostat hydrochloride monohydrate,inhibit,HDAC,Histone deacetylases,Inhibitor

6-[(Diethylamino)methyl]-2-naphthyl]methyl [4-(Hydroxycarbamoyl)phenyl]carbamate Hydrochloride Hydrate

Givinostat hydrochloride monohydrate, 10 mM in DMSO

732302-99-7

C24H27N3O4HClH2O

Inhibitor

Inhibitors