AR-42
- Product Name
- AR-42
- CAS No.
- 935881-37-1
- Chemical Name
- AR-42
- Synonyms
- AR-42;CS-15;OSU-HD;HDAC-42;RSYYAR-42;OSU-HDAC42;(S)-HDAC 42;NSC-D736012;AR-42 (HDAC-42);(S)-HDAC-42,AR-42
- CBNumber
- CB82525936
- Molecular Formula
- C18H20N2O3
- Formula Weight
- 312.36
- MOL File
- 935881-37-1.mol
AR-42 Property
- Density
- 1.223
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥15.62 mg/mL in DMSO
- form
- Powder
- pka
- 8.94±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A735450
- Product name
- AR-42
- Packaging
- 10mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- A735450
- Product name
- AR-42
- Packaging
- 2mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- A735450
- Product name
- AR-42
- Packaging
- 100mg
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- INB0001190
- Product name
- AR-42
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1443.75
- Updated
- 2021/12/16
- Product number
- A4104
- Product name
- AR-42(OSU-HDAC42)
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
AR-42 Chemical Properties,Usage,Production
Uses
AR-42 is a broad spectrum deacetylase inhibitor of both histone and non-histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies. AR-42 is k nown utilized as a novel, oral cancer therapy currently in early clinical development.
Definition
ChEBI: (S)-HDAC-42 is an amidobenzoic acid.
Biological Activity
ar-42 (also known as osu-hdac42), a derivative of hydroxamate-tethered phenylbutyrate, is a novel and potent inhibitor of histone deacetylase (hdac) that potently inhibits the activity of hdac with 50% inhibition concentration ic50 value of 16 nm and induces histone h3 acetylation, α-tubulin acetylation and p21 up-regulation, which have been considered as the hallmark indicators of hdac inhibition. ar-42 has been found to modulate several apoptosis inhibitors as well as cell survival regulator, including akt, bcl-xl, bax, ku70 and surviving, and exert potent antitumor activity against multiple tumor types, such as human prostate and hepatic cancers, at least partially through pi3k/akt pathway inhibition.matthew l. bush†, janet oblinger†, victoria brendel, griffin santarelli, jie huang, elena m. akhmametyeva, sarah s. burns, justin wheeler, jeremy davis, charles w. yates, abhik r. chaudhury, samuel kulp, ching-shih chen, long-sheng chang, d. bradley welling, and abraham jacob. ar42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas. neuro-oncology 13(9):983–999, 2011aaron m. sargeant, robert c. rengel, samuel k. kulp, et al. osu-hdac42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model cancer res 2008;68:3999-4009.qiang lu, da-sheng wang, chang-shi chen, yuan-dong hu, and ching-shih chen. structure-based optimization of phenylbutyrate-derived histone deacetylaseinhibitors. j. med. chem. 2005, 48, 5530-5535
target
HDAC
AR-42 Preparation Products And Raw materials
Raw materials
Preparation Products
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