ChemicalBook > CAS DataBase List > AR-42

AR-42

Product Name: AR-42
CAS No.: 935881-37-1
Chemical Name: AR-42
Synonyms: AR-42;CS-15;OSU-HD;HDAC-42;RSYYAR-42;OSU-HDAC42;(S)-HDAC 42;NSC-D736012;AR-42 (HDAC-42);(S)-HDAC-42,AR-42
CBNumber: CB82525936
Molecular Formula: C18H20N2O3
Formula Weight: 312.36
MOL File: 935881-37-1.mol

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AR-42 Property

Density: 1.223
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥15.62 mg/mL in DMSO
form: Powder
pka: 8.94±0.10(Predicted)
color: White to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A735450
Product name: AR-42
Packaging: 2mg
Price: $55
Updated: 2021/12/16

TRC

Product number: A735450
Product name: AR-42
Packaging: 10mg
Price: $165
Updated: 2021/12/16

TRC

Product number: A735450
Product name: AR-42
Packaging: 100mg
Price: $1230
Updated: 2021/12/16

ApexBio Technology

Product number: A4104
Product name: AR-42(OSU-HDAC42)
Packaging: 1unit
Price: $28
Updated: 2021/12/16

ApexBio Technology

Product number: A4104
Product name: AR-42(OSU-HDAC42)
Packaging: 2mg
Price: $50
Updated: 2021/12/16

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AR-42 Chemical Properties,Usage,Production

Uses

AR-42 is a broad spectrum deacetylase inhibitor of both histone and non-histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies. AR-42 is k nown utilized as a novel, oral cancer therapy currently in early clinical development.

Definition

ChEBI: (S)-HDAC-42 is an amidobenzoic acid.

Biological Activity

ar-42 (also known as osu-hdac42), a derivative of hydroxamate-tethered phenylbutyrate, is a novel and potent inhibitor of histone deacetylase (hdac) that potently inhibits the activity of hdac with 50% inhibition concentration ic50 value of 16 nm and induces histone h3 acetylation, α-tubulin acetylation and p21 up-regulation, which have been considered as the hallmark indicators of hdac inhibition. ar-42 has been found to modulate several apoptosis inhibitors as well as cell survival regulator, including akt, bcl-xl, bax, ku70 and surviving, and exert potent antitumor activity against multiple tumor types, such as human prostate and hepatic cancers, at least partially through pi3k/akt pathway inhibition.matthew l. bush†, janet oblinger†, victoria brendel, griffin santarelli, jie huang, elena m. akhmametyeva, sarah s. burns, justin wheeler, jeremy davis, charles w. yates, abhik r. chaudhury, samuel kulp, ching-shih chen, long-sheng chang, d. bradley welling, and abraham jacob. ar42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas. neuro-oncology 13(9):983–999, 2011aaron m. sargeant, robert c. rengel, samuel k. kulp, et al. osu-hdac42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model cancer res 2008;68:3999-4009.qiang lu, da-sheng wang, chang-shi chen, yuan-dong hu, and ching-shih chen. structure-based optimization of phenylbutyrate-derived histone deacetylaseinhibitors. j. med. chem. 2005, 48, 5530-5535

in vivo

AR-42 (10 mg/kg; tail vein injection; twice a week for three weeks) significantly inhibites tumor growth^[4].

Animal Model:	Nude mice (HepG2 cell tumor xenograft model) ^[4]
Dosage:	10 mg/kg
Administration:	Tail vein injection; twice a week for three weeks
Result:	Significantly inhibited tumor growth.

target

HDAC

AR-42 Preparation Products And Raw materials

Raw materials

Preparation Products

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935881-37-1, AR-42Related Search:

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AR-42

(S)-HDAC-42,AR-42

(S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)benzamide

(S)-HDAC 42

AR-42 (HDAC-42)

HDAC-42

OSU-HDAC42

AR-42 (OSU-HDAC42)

(S)-N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide

(S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)benzamide AR 42

N-hydroxy-4-[(3-methyl-1-oxo-2-phenylbutyl)amino]benzamide

NSC-D736012

CS-15

Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-α-(1-methylethyl)-, (αS)-

OSU-HD

AR-42 (HDAC-42, NSC-736012, OSU-42)

AR-42 OSU-HDAC42 AR42 HDAC-42

RSYYAR-42

AR42, 10 mM in DMSO

935881-37-1

Inhibitors

Inhibitor