ChemicalBook > CAS DataBase List > AR-42

AR-42

Product Name
AR-42
CAS No.
935881-37-1
Chemical Name
AR-42
Synonyms
AR-42;CS-15;OSU-HD;HDAC-42;RSYYAR-42;OSU-HDAC42;(S)-HDAC 42;NSC-D736012;AR-42 (HDAC-42);(S)-HDAC-42,AR-42
CBNumber
CB82525936
Molecular Formula
C18H20N2O3
Formula Weight
312.36
MOL File
935881-37-1.mol
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AR-42 Property

Density 
1.223
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥15.62 mg/mL in DMSO
form 
Powder
pka
8.94±0.10(Predicted)
color 
White to light brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A735450
Product name
AR-42
Packaging
10mg
Price
$165
Updated
2021/12/16
TRC
Product number
A735450
Product name
AR-42
Packaging
2mg
Price
$55
Updated
2021/12/16
TRC
Product number
A735450
Product name
AR-42
Packaging
100mg
Price
$1230
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001190
Product name
AR-42
Purity
95.00%
Packaging
5G
Price
$1443.75
Updated
2021/12/16
ApexBio Technology
Product number
A4104
Product name
AR-42(OSU-HDAC42)
Packaging
5mg
Price
$105
Updated
2021/12/16
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AR-42 Chemical Properties,Usage,Production

Uses

AR-42 is a broad spectrum deacetylase inhibitor of both histone and non-histone proteins, which has demonstrated greater potency and activity in solid tumors and hematological malignancies. AR-42 is k nown utilized as a novel, oral cancer therapy currently in early clinical development.

Definition

ChEBI: (S)-HDAC-42 is an amidobenzoic acid.

Biological Activity

ar-42 (also known as osu-hdac42), a derivative of hydroxamate-tethered phenylbutyrate, is a novel and potent inhibitor of histone deacetylase (hdac) that potently inhibits the activity of hdac with 50% inhibition concentration ic50 value of 16 nm and induces histone h3 acetylation, α-tubulin acetylation and p21 up-regulation, which have been considered as the hallmark indicators of hdac inhibition. ar-42 has been found to modulate several apoptosis inhibitors as well as cell survival regulator, including akt, bcl-xl, bax, ku70 and surviving, and exert potent antitumor activity against multiple tumor types, such as human prostate and hepatic cancers, at least partially through pi3k/akt pathway inhibition.matthew l. bush†, janet oblinger†, victoria brendel, griffin santarelli, jie huang, elena m. akhmametyeva, sarah s. burns, justin wheeler, jeremy davis, charles w. yates, abhik r. chaudhury, samuel kulp, ching-shih chen, long-sheng chang, d. bradley welling, and abraham jacob. ar42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas. neuro-oncology 13(9):983–999, 2011aaron m. sargeant, robert c. rengel, samuel k. kulp, et al. osu-hdac42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model cancer res 2008;68:3999-4009.qiang lu, da-sheng wang, chang-shi chen, yuan-dong hu, and ching-shih chen. structure-based optimization of phenylbutyrate-derived histone deacetylaseinhibitors. j. med. chem. 2005, 48, 5530-5535

target

HDAC

AR-42 Preparation Products And Raw materials

Raw materials

Preparation Products

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AR-42 Suppliers

Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71

935881-37-1, AR-42Related Search:


  • AR-42
  • (S)-HDAC-42,AR-42
  • (S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)benzamide
  • (S)-HDAC 42
  • AR-42 (HDAC-42)
  • HDAC-42
  • OSU-HDAC42
  • AR-42 (OSU-HDAC42)
  • (S)-N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide
  • (S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)benzamide AR 42
  • N-hydroxy-4-[(3-methyl-1-oxo-2-phenylbutyl)amino]benzamide
  • NSC-D736012
  • CS-15
  • Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-α-(1-methylethyl)-, (αS)-
  • OSU-HD
  • AR-42 (HDAC-42, NSC-736012, OSU-42)
  • AR-42 OSU-HDAC42 AR42 HDAC-42
  • RSYYAR-42
  • 935881-37-1
  • Inhibitors
  • Inhibitor