ChemicalBook > CAS DataBase List > N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide

N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide

Product Name
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
CAS No.
123664-84-6
Chemical Name
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
Synonyms
Eramod Impurity 4;Iguratimod Impurity 7;N-(5-Methoxy-2-phenoxyphenyl);N-(5-Methoxy-2-Phenoxyphenyl)methanesulfonamide;MethanesulfonaMide, N-(5-Methoxy-2-phenoxyphenyl)-;N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide (Aimolade intermediate 3);MethanesulfonaMide, N-(5-Methoxy-2-phenoxyphenyl)- Iguratimod Impurity 7
CBNumber
CB12563425
Molecular Formula
C14H15NO4S
Formula Weight
293.34
MOL File
123664-84-6.mol
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N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Property

Boiling point:
411.4±55.0 °C(Predicted)
Density 
1.306±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
8.07±0.10(Predicted)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C14H15NO4S/c1-18-12-8-9-14(13(10-12)15-20(2,16)17)19-11-6-4-3-5-7-11/h3-10,15H,1-2H3
InChIKey
HKQJXMJGWKDFTA-UHFFFAOYSA-N
SMILES
CS(NC1=CC(OC)=CC=C1OC1=CC=CC=C1)(=O)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

AK Scientific
Product number
4508AA
Product name
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
Packaging
1g
Price
$159
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0079795
Product name
N-(5-METHOXY-2-PHENOXYPHENYL)METHANESULFONAMIDE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0079795
Product name
N-(5-METHOXY-2-PHENOXYPHENYL)METHANESULFONAMIDE
Purity
95.00%
Packaging
10G
Price
$1334.03
Updated
2021/12/16
Ambeed
Product number
A138910
Product name
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
Purity
98%
Packaging
100mg
Price
$19
Updated
2021/12/16
Ambeed
Product number
A138910
Product name
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
Purity
98%
Packaging
250mg
Price
$19
Updated
2021/12/16
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N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Chemical Properties,Usage,Production

Synthesis

76838-72-7

124-63-0

123664-84-6

(4) Dissolve 10.0 g of 3-amino-4-phenoxyanisole in 50 mL of pyridine. Under cooling conditions in an ice bath, 5.59 g of methanesulfonyl chloride was added slowly dropwise for a controlled time of 10 minutes. The reaction mixture was stirred continuously at 20°C to 25°C for 1 hour. Subsequently, the reaction mixture was poured into a mixture consisting of 200 ml of ethyl acetate and 100 ml of water. The organic layer was separated and washed sequentially with three 100-mL portions of 2N hydrochloric acid and saturated aqueous sodium chloride. After separation of the organic layer, it was dried with anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure. The resulting crude product was recrystallized by isopropanol to give 12.5 g (yield: 91.9%) of N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide with a melting point of 109.5°C to 111°C. IR (KBr, cm-1): 3250, 1610, 1585, 1480, 1320, 1220, 1150. nMR (CDCl3) δ: 2.94 (3H, s), 3.81 (3H, s), 6.36-7.43 (9H, m).

References

[1] Patent: US4954518, 1990, A
[2] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 1, p. 131 - 139

N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Suppliers

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123664-84-6, N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamideRelated Search:

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