2-Chloro-5-methoxyaniline

Product Name: 2-Chloro-5-methoxyaniline
CAS No.: 2401-24-3
Chemical Name: 2-Chloro-5-methoxyaniline
Synonyms: Eramod Impurity 5;2-Chloro-5-methoxyan;2-CHLORO-M-ANISIDINE;6-Chloro-m-anisidine;2-Chloro-5-anisidine;2-Chloro-5-methoxyani;3-AMINO-4-CHLOROANISOLE;2-Chloro-5-Methxyaniline;2-CHLORO-5-METHOXYANILINE;6-Chloro-m-anisidine (NH2=1)
CBNumber: CB9144547
Molecular Formula: C7H8ClNO
Formula Weight: 157.6
MOL File: 2401-24-3.mol

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2-Chloro-5-methoxyaniline Property

Melting point:: 207 °C (dec.)(lit.)
Boiling point:: 135-137°C 12mm
Density: 1.261 g/mL at 25 °C
refractive index: 1.5848
Flash point:: 135-137°C/12mm
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to lump to clear liquid
pka: 2.23±0.10(Predicted)
color: White or Colorless to Yellow to Orange
Water Solubility: Slightly soluble in water.
BRN: 2082193
InChI: InChI=1S/C7H8ClNO/c1-10-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3
InChIKey: GBOUQGUQUUPGLO-UHFFFAOYSA-N
SMILES: C1(N)=CC(OC)=CC=C1Cl
CAS DataBase Reference: 2401-24-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-37/39-36-36/37
RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 736392
Product name: 2-Chloro-5-methoxyaniline
Purity: 97%
Packaging: 5g
Price: $43.95
Updated: 2025/07/31

TCI Chemical

Product number: C3053
Product name: 2-Chloro-5-methoxyaniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $75
Updated: 2025/07/31

TRC

Product number: C349610
Product name: 2-Chloro-5-methoxyaniline
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC03021
Product name: 2-Chloro-5-methoxyaniline
Packaging: 5G
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: Q967
Product name: 2-Chloro-5-methoxyaniline
Packaging: 25g
Price: $107
Updated: 2021/12/16

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2-Chloro-5-methoxyaniline Chemical Properties,Usage,Production

Uses

2-Chloro-5-methoxyaniline is used in the preparation of 4-amino-5-chloro-2-methoxyphenyl thiocyanate.

Synthesis

10298-80-3

2401-24-3

General procedure for the synthesis of 2-chloro-5-methoxyaniline from 4-chloro-3-nitroanisole: nitro compounds (0.6 mmol) and ethanol (2 mL) were added to a sealed tube, followed by hydrazine hydrate (2.6-6.0 mmol, cf. Table 2) and an Au/TiO2 catalyst (100 mg, 1 wt%, with 0.8 mol% [Au]). The reaction mixture was heated at 60 °C for an appropriate time under an inert atmosphere (see Table 2). The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction slurry was filtered under pressure through a short pad of diatomaceous earth and silica gel and washed using ethanol or methanol (~5 mL) to recover the loaded catalyst. The filtrate was evaporated under vacuum to give pure 2-chloro-5-methoxyaniline. The nuclear magnetic resonance hydrogen (1H NMR) and carbon (13C NMR) spectral data of the products 1a-20a were in agreement with those reported in the literature [28,30,31] and most of the products were commercially available chemicals. The Au/TiO2, Au/Al2O3 and Au/ZnO catalysts used (~1 wt% Au content) were purchased from Strem Chemicals and the average size of their Au microcrystals was about 2-3 nm.

References

[1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] New Journal of Chemistry, 2015, vol. 39, # 7, p. 5360 - 5365
[3] Chemistry - A European Journal, 2016, vol. 22, # 13, p. 4600 - 4607
[4] Catalysis Communications, 2013, vol. 36, p. 48 - 51
[5] ACS Catalysis, 2014, vol. 4, # 10, p. 3504 - 3511

2-Chloro-5-methoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-methoxyaniline Suppliers

Americas 1 China 168 Europe 3 France 1 Germany 2 India 32 Japan 2 Switzerland 1 Ukraine 1 United Kingdom 13 United States 30 Global 254

Changzhou Hongda New Material Technology Co., Ltd.

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China DongFan Chemical Co.,LTD

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View Lastest Price from 2-Chloro-5-methoxyaniline manufacturers

Honest Joy Holdings Limited

Product: 2-Chloro-5-methoxyaniline 2401-24-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.9%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 2-Chloro-5-methoxyaniline 2401-24-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-10

2401-24-3, 2-Chloro-5-methoxyanilineRelated Search:

o-Anisidine p-Anisidine 2-Chloroaniline 3-Ethoxyaniline 4-(Trifluoromethoxy)aniline 4-Methoxybenzylchloride 4-Chloroaniline Chlorpropham m-Anisidine 4-Chloro-3-nitroanisole N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Iguratimod Impurity 10 Iguratimod N-(4-(2-aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride MethanesulfonaMide, N-[4-[2-(forMylaMino)acetyl]-5-hydroxy-2-phenoxyphenyl]- Iguratimod Impurity 11 Phenol Iguratimod Impurity 2

2-Chloro-5-methoxyaniline, 98+%

1-Amino-2-chloro-5-methoxybenzene

2-Chloro-5-methoxybenzenamine

2-Chloro-5-methoxyan

3-Amino-4-chloroanisole, 6-Chloro-m-anisidine

2-chloro-5-MethoxybenzenaMine hydrochloride

3-Amino-4-chloroanisole [2-Chloro-5-methoxyaniline]

2-CHLORO-5-METHOXYANILINE

2-CHLORO-M-ANISIDINE

3-Amino-4-chloroanisole Hydrochloride

3-AMINO-4-CHLOROANISOLE

6 Chloro Meta Anisidine ( 2 chloro 5 methoxy Aniline )

6-Chloro-m-anisidine

6-chloro-meta-anisidine hydrochloride

2-Chloro-5-methoxyaniline Hcl

6-Chloro-m-anisidine(NH2=1),HCl

2-Chloro-5-anisidine

6-Chloro-m-anisidine (NH2=1)

6-CHLORO-META ALPHA-ANISIDINE HYDROCHLORIDE 98%

2-Chloro-5-Methxyaniline

Benzenamine, 2-chloro-5-methoxy-

2-Chloro-5-methoxyaniline ISO 9001：2015 REACH

2-Chloro-5-methoxyani

Eramod Impurity 5

2401-24-3

2401-24-23

C7H8CINO

C7H8ClNOxHCl

Organic Building Blocks

Nitrogen Compounds

Amine Salts

Building Blocks

Anilines, Amides & Amines

Anisoles, Alkyloxy Compounds & Phenylacetates

Chlorine Compounds

Anilines, Aromatic Amines and Nitro Compounds