N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
- Product Name
- N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
- CAS No.
- 123664-84-6
- Chemical Name
- N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
- Synonyms
- Eramod Impurity 4;Iguratimod Impurity 7;N-(5-Methoxy-2-phenoxyphenyl);N-(5-Methoxy-2-Phenoxyphenyl)methanesulfonamide;MethanesulfonaMide, N-(5-Methoxy-2-phenoxyphenyl)-;N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide (Aimolade intermediate 3);MethanesulfonaMide, N-(5-Methoxy-2-phenoxyphenyl)- Iguratimod Impurity 7
- CBNumber
- CB12563425
- Molecular Formula
- C14H15NO4S
- Formula Weight
- 293.34
- MOL File
- 123664-84-6.mol
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Property
- Boiling point:
- 411.4±55.0 °C(Predicted)
- Density
- 1.306±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.07±0.10(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C14H15NO4S/c1-18-12-8-9-14(13(10-12)15-20(2,16)17)19-11-6-4-3-5-7-11/h3-10,15H,1-2H3
- InChIKey
- HKQJXMJGWKDFTA-UHFFFAOYSA-N
- SMILES
- CS(NC1=CC(OC)=CC=C1OC1=CC=CC=C1)(=O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 4508AA
- Product name
- N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
- Packaging
- 1g
- Price
- $159
- Updated
- 2021/12/16
- Product number
- CHM0079795
- Product name
- N-(5-METHOXY-2-PHENOXYPHENYL)METHANESULFONAMIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- CHM0079795
- Product name
- N-(5-METHOXY-2-PHENOXYPHENYL)METHANESULFONAMIDE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1334.03
- Updated
- 2021/12/16
- Product number
- CM125908
- Product name
- N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $247
- Updated
- 2021/12/16
- Product number
- CD12170186
- Product name
- N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide
- Purity
- 98%
- Packaging
- 1g
- Price
- $260
- Updated
- 2021/12/16
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Chemical Properties,Usage,Production
Synthesis
76838-72-7
124-63-0
123664-84-6
(4) Dissolve 10.0 g of 3-amino-4-phenoxyanisole in 50 mL of pyridine. Under cooling conditions in an ice bath, 5.59 g of methanesulfonyl chloride was added slowly dropwise for a controlled time of 10 minutes. The reaction mixture was stirred continuously at 20°C to 25°C for 1 hour. Subsequently, the reaction mixture was poured into a mixture consisting of 200 ml of ethyl acetate and 100 ml of water. The organic layer was separated and washed sequentially with three 100-mL portions of 2N hydrochloric acid and saturated aqueous sodium chloride. After separation of the organic layer, it was dried with anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure. The resulting crude product was recrystallized by isopropanol to give 12.5 g (yield: 91.9%) of N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide with a melting point of 109.5°C to 111°C. IR (KBr, cm-1): 3250, 1610, 1585, 1480, 1320, 1220, 1150. nMR (CDCl3) δ: 2.94 (3H, s), 3.81 (3H, s), 6.36-7.43 (9H, m).
References
[1] Patent: US4954518, 1990, A
[2] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 1, p. 131 - 139
N-(5-Methoxy-2-phenoxyphenyl)methanesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
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