ChemicalBook > CAS DataBase List > 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL

1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL

Product Name
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL
CAS No.
119022-51-4
Chemical Name
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL
Synonyms
TIMTEC-BB SBB000154;Pyroxasulfone Impurity 1;1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL;5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-3-OL;2-methyl-3-(trifluoromethyl)-1H-pyrazol-5-one;3-HYDROXY-1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE;3-HYDROXY-1-METHYL-5-TRIFLUOROMETHYL-1H-PYRAZOLE;5-HYDROXY-2-METHYL-3-TRIFLUOROMETHYL-1H-PYRAZOLE;1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol,99+%;3-Hydroxy-1-methyl-5-(trifluoromethyl)pyrazole97%
CBNumber
CB1256895
Molecular Formula
C5H5F3N2O
Formula Weight
166.1
MOL File
119022-51-4.mol
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1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL Property

Melting point:
114-115 °C
Density 
1.3876 (estimate)
storage temp. 
Sealed in dry,Room Temperature
pka
7.35±0.70(Predicted)
Appearance
White to yellow Solid
BRN 
3543409
CAS DataBase Reference
119022-51-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-25
Safety Statements 
24/25-45-26
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Frontier Specialty Chemicals
Product number
CAPOD11112
Product name
3-Hydroxy-1-methyl-5-(trifluoromethyl)pyrazole
Purity
98%
Packaging
1g
Price
$19
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
CAPOD11112
Product name
3-Hydroxy-1-methyl-5-(trifluoromethyl)pyrazole
Purity
98%
Packaging
5g
Price
$63
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD95191
Product name
1,2-Dihydro-1-Methyl-5-(Trifluoromethyl)-3H-Pyrazol-3-One
Packaging
500mg
Price
$75
Updated
2021/12/16
Oakwood
Product number
010737
Product name
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol
Packaging
1g
Price
$98
Updated
2021/12/16
Matrix Scientific
Product number
044751
Product name
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol
Purity
>95%
Packaging
500mg
Price
$118
Updated
2021/12/16
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1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL Chemical Properties,Usage,Production

Chemical Properties

White to yellow or pink crystalline powder

Definition

ChEBI: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol is a member of pyrazoles.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 243, 1990 DOI: 10.1002/jhet.5570270224

Synthesis

372-31-6

60-34-4

119022-51-4

The general procedure for the synthesis of 1-methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one from ethyl trifluoroacetoacetate and methylhydrazine was as follows: 6 kg of ethyl ether and 6164.2 g (33.5 mol) of ethyl trifluoroacetoacetate were added to a reaction flask. Under continuous stirring, 1542.4 g (33.5 mol) of methylhydrazine was slowly added and the temperature was maintained at about 24 °C during the reaction. After continued stirring for 1 hour, the reaction was confirmed to be complete. Subsequently, most of the ether solvent was removed by vapor extraction and the residue was slurried in 12 L of chloroform. To the slurried mixture was added 50 mL of concentrated sulfuric acid with continuous stirring overnight. Next, another 100 mL of sulfuric acid was added, and the slurry was washed once with 3 L of water, followed by five washes with 3 L of 10% sodium bicarbonate solution to remove the 5-hydroxy isomer, and finally two washes with 3 L of water. The aqueous layer and undissolved crystals were sequentially extracted twice with 4 L of chloroform. The chloroform layers were combined and concentrated under reduced pressure on a rotary evaporator at 40 °C to give 1405.9 g (25.3% yield) of the target product with a melting point of 205 °C (literature value 130°-131 °C).

References

[1] Patent: US4855442, 1989, A

1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Chloroform Diethyl ether Methylhydrazine

Preparation Products

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View Lastest Price from 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one 119022-51-4
Price
US $1.60-9.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-20
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL 119022-51-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL 119022-51-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
600kg
Release date
2019-12-25

119022-51-4, 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OLRelated Search:

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-5-OL 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL 1-[(4-CHLOROPHENYL)SULFONYL]-3-([1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL]OXY)-2-PROPANOL 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL N-(4-FLUOROPHENYL)CARBAMATE 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL N-PROPYLCARBAMATE 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL N-ALLYLCARBAMATE S-(TERT-BUTYL) 2-([1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL]OXY)ETHANETHIOATE 1-(BENZYLSULFONYL)-3-([1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL]OXY)-2-PROPANOL 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL N-(2,6-DIMETHYLPHENYL)CARBAMATE 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL 5-(TRIFLUOROMETHYL)-2-PYRIDINYL ETHER 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL N-PHENYLCARBAMATE METHYL 2-([1-METHYL-5-(TRIFLUOROMETHYL)-1H-3-PYRAZOLYL]OXY)ACETATE 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL N-(3-CHLOROPHENYL)CARBAMATE 2-([1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL]OXY)-1-MORPHOLINO-1-ETHANONE 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL N-CYCLOHEXYLCARBAMATE 3-CHLORO-2-([1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL]OXY)-5-(TRIFLUOROMETHYL)PYRIDINE 5-(4-CHLOROPHENYL)-2-([1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL]OXY)PYRIMIDINE 1-[(4-METHOXYBENZYL)SULFONYL]-3-([1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-YL]OXY)-2-PROPANOL

  • TIMTEC-BB SBB000154
  • 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol,99+%
  • 3-Hydroxy-1-methyl-5-(trifluoromethyl)pyrazole 97%
  • 3-Hydroxy-1-methyl-5-(trifluoromethyl)pyrazole97%
  • 5-HYDROXY-2-METHYL-3-TRIFLUOROMETHYL-1H- PYRAZOLE 99+%
  • 5-HYDROXY-2-METHYL-3-TRIFLUOROMETHYL-1H-PYRAZOLE
  • 3-HYDROXY-1-METHYL-5-TRIFLUOROMETHYL-1H-PYRAZOLE
  • 3-HYDROXY-1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE
  • 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-3-OL
  • 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL
  • 3-Hydroxy-1-methyl-5-trifluoromethyl-1H-pyrazole, 99+%
  • 1,2-Dihydro-1-methyl-5-(trifluoromethyl)-3H-pyrazol-3-one
  • 1-Methyl-5-(trifluoromethyl)-1h-pyrazol-3-ol ,97%
  • 3H-Pyrazol-3-one, 1,2-dihydro-1-Methyl-5-(trifluoroMethyl)-
  • 1-Methyl-5-(trifluoroMethyl)-1H-pyrazol-3(2H)-one
  • 2-methyl-3-(trifluoromethyl)-1H-pyrazol-5-one
  • 3-<WBR>Hydroxy-<WBR>1-<WBR>methyl-<WBR>5-<WBR>(trifluoromethyl)<WBR>pyrazole
  • Pyroxasulfone Impurity 1
  • 119022-51-4
  • 1119022-51-4
  • C5H5F3N2O
  • Building Blocks
  • Pyrazole
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