ChemicalBook > CAS DataBase List > CCT241533

CCT241533

Product Name
CCT241533
CAS No.
1262849-73-9
Chemical Name
CCT241533
Synonyms
CS-198;CCT241533;CCT241533 (CCT 241533;4-Fluoro-2-(4-(((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol;3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, (3R,4S)-;(3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol
CBNumber
CB12570371
Molecular Formula
C23H27FN4O4
Formula Weight
442.4832832
MOL File
1262849-73-9.mol
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CCT241533 Property

Boiling point:
569.4±50.0 °C(Predicted)
Density 
1.327
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
pka
8.18±0.48(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C227905
Product name
CCT241533
Packaging
50mg
Price
$815
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611866
Product name
CCT241533
Purity
>98%
Packaging
50mg
Price
$994.5
Updated
2021/12/16
ApexBio Technology
Product number
A3291
Product name
CCT241533
Packaging
50mg
Price
$1559
Updated
2021/12/16
ApexBio Technology
Product number
A3291
Product name
CCT241533
Packaging
2mg
Price
$134
Updated
2021/12/16
ApexBio Technology
Product number
A3291
Product name
CCT241533
Packaging
5mg
Price
$202
Updated
2021/12/16
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CCT241533 Chemical Properties,Usage,Production

Uses

CCT241533 is an inhibitor of checkpoint kinase 2, which is a potential antitumor and radioprotectant.

Biological Activity

chk2 is a checkpoint kinase involved in the atm-mediated response to double-strand dna breaks. inhibitors of chk2 may increase the efficacy of genotoxic cancer therapies. cct241533 has been identified and characterized as a novel chk2 kinase inhibitor.in silico: x-ray crystallography confirmed that cct241533 bound to chk2 in the atp pocket. overall, the binding mode was found to be very highly conserved relative to previous compounds, with all of the key hydrogen bond interactions maintained. the potency gained with cct241533 therefore appears to be due to the presence of the two methoxy substituents occupying the solvent exposed region of the enzyme, and contributions from the isopropyl alcohol substituent, which may participate in a second intramolecular hydrogen bond to the quinazoline exocyclicnh [2].

in vitro

cct241533 inhibits chk2 with an ic50 of 3 nmol/l and shows minimal cross-reactivity against a panel of kinases at 1 mmol/l. cct241533 did not potentiate the cytotoxicity of a selection of genotoxic agents in several cell lines [1]. moreover, as the most potent chk2 inhibitor identified in the series, cct241533 shows potent selectivity (63-fold) over chk1 and low herg inhibition (hergic50=22 μm) [2].

References

[1] anderson ve, walton mi, eve pd, boxall kj, antoni l, caldwell jj, aherne w, pearl lh, oliver aw, collins i, garrett md. cct241533 is a potent and selective inhibitor of chk2 that potentiates the cytotoxicity of parp inhibitors. cancer res. 2011;71(2):463-72.
[2] caldwell jj, welsh ej, matijssen c, anderson ve, antoni l, boxall k, urban f, hayes a, raynaud fi, rigoreau lj, raynham t, aherne gw, pearl lh, oliver aw, garrett md, collins i. structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. j med chem. 2011;54(2):580-90.

CCT241533 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT241533 Suppliers

Chembest Research Laboratories Limited
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021-20908456
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NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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+86-27-87599188
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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LETOPHARM LIMITED
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SPIRO PHARMA
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eric_feng1954@126.com
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China
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Chengdu Dianchun Technology Co., Ltd
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400-1166-196 18502815961
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Fan De(Beijing) Biotechnology Co., Ltd.
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career henan chemical co
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Absin Bioscience Inc.
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TargetMol Chemicals Inc.
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Nanjing Shizhou Biology Technology Co.,Ltd
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Jilin Chinese Academy of Sciences-yanshen Technology
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Jilin Chinese Academy of Sciences-yanshen Technology
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Beijing Dongge Boye Biotechnology Co., Ltd.
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Beijing Fubo Biotechnology Co., Ltd.
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Shanghai Yijie Biological Technology Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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Shanghai Boyi Biotechnology Co., Ltd.
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Xiamen Huijia Biological Technology Co., Ltd.
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View Lastest Price from CCT241533 manufacturers

Career Henan Chemical Co
Product
CCT241533 1262849-73-9
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10

1262849-73-9, CCT241533Related Search:


  • (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol
  • CCT241533
  • CCT241533 (CCT 241533
  • CS-198
  • 3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, (3R,4S)-
  • 4-Fluoro-2-(4-(((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol
  • 1262849-73-9