CCT241533 Property

Boiling point:

569.4±50.0 °C(Predicted)

Density 

1.327

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

crystalline solid

pka

8.18±0.48(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

CCT241533 Chemical Properties,Usage,Production

Uses

CCT241533 is an inhibitor of checkpoint kinase 2, which is a potential antitumor and radioprotectant.

Biological Activity

chk2 is a checkpoint kinase involved in the atm-mediated response to double-strand dna breaks. inhibitors of chk2 may increase the efficacy of genotoxic cancer therapies. cct241533 has been identified and characterized as a novel chk2 kinase inhibitor.in silico: x-ray crystallography confirmed that cct241533 bound to chk2 in the atp pocket. overall, the binding mode was found to be very highly conserved relative to previous compounds, with all of the key hydrogen bond interactions maintained. the potency gained with cct241533 therefore appears to be due to the presence of the two methoxy substituents occupying the solvent exposed region of the enzyme, and contributions from the isopropyl alcohol substituent, which may participate in a second intramolecular hydrogen bond to the quinazoline exocyclicnh [2].

in vitro

cct241533 inhibits chk2 with an ic50 of 3 nmol/l and shows minimal cross-reactivity against a panel of kinases at 1 mmol/l. cct241533 did not potentiate the cytotoxicity of a selection of genotoxic agents in several cell lines [1]. moreover, as the most potent chk2 inhibitor identified in the series, cct241533 shows potent selectivity (63-fold) over chk1 and low herg inhibition (hergic50=22 μm) [2].

References

[1] anderson ve, walton mi, eve pd, boxall kj, antoni l, caldwell jj, aherne w, pearl lh, oliver aw, collins i, garrett md. cct241533 is a potent and selective inhibitor of chk2 that potentiates the cytotoxicity of parp inhibitors. cancer res. 2011;71(2):463-72.
[2] caldwell jj, welsh ej, matijssen c, anderson ve, antoni l, boxall k, urban f, hayes a, raynaud fi, rigoreau lj, raynham t, aherne gw, pearl lh, oliver aw, garrett md, collins i. structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. j med chem. 2011;54(2):580-90.