ChemicalBook > CAS DataBase List > CAY10602

CAY10602

Product Name: CAY10602
CAS No.: 374922-43-7
Chemical Name: CAY10602
Synonyms: CAY10602;CAY10602 HCl;CAY10602, >98%;SIRT1 Activator II;CAY10602, 10 mM in DMSO;CAY10602, SIRT1 Activator;SIRT1 Activator II - CAS 374922-43-7 - Calbiochem;Inhibitor,CAY 10602,CAY10602,CAY-10602,inhibit,Sirtuin;1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine;1H-Pyrrolo[2,3-b]quinoxalin-2-amine, 1-(4-fluorophenyl)-3-(phenylsulfonyl)-
CBNumber: CB12590438
Molecular Formula: C22H15FN4O2S
Formula Weight: 418.44
MOL File: 374922-43-7.mol

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CAY10602 Property

Melting point:: 270 °C
storage temp.: +2C to +8C
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
form: Off-white powder
color: Light yellow to Amber to Dark green
CAS DataBase Reference: 374922-43-7

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Safety

HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 566313
Product name: SIRT1 Activator II - CAS 374922-43-7 - Calbiochem<br />The SIRT1 Activator II, also referenced under CAS 374922-43-7, modulates the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Biochemicals applications.
Packaging: 10mg
Price: $110
Updated: 2025/07/31

TCI Chemical

Product number: F1204
Product name: 1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
Packaging: 10MG
Price: $82
Updated: 2025/07/31

TCI Chemical

Product number: F1204
Product name: 1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
Packaging: 50MG
Price: $303
Updated: 2025/07/31

Cayman Chemical

Product number: 10009796
Product name: CAY10602
Purity: ≥95%
Packaging: 5mg
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 10009796
Product name: CAY10602
Purity: ≥95%
Packaging: 10mg
Price: $56
Updated: 2024/03/01

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CAY10602 Chemical Properties,Usage,Production

Uses

CAY10602 is a SIRT1 activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells[1].

General Description

A cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator (10 μM causes ~2.3-fold fluorescent enhancement in a fluorescent assay using hrSIRT1) and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. Shown to inhibit LPS-induced TNF-α release in THP-1 cells by ~10-fold more potent than resveratrol (Cat. No. 554325).

IC 50

SIRT1

References

[1] Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11(8):959-67. DOI:10.1177/1087057106294710

CAY10602 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10602 Suppliers

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374922-43-7, CAY10602Related Search:

CAY10602

1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine

SIRT1 Activator II - CAS 374922-43-7 - Calbiochem

CAY10602, >98%

1H-Pyrrolo[2,3-b]quinoxalin-2-amine, 1-(4-fluorophenyl)-3-(phenylsulfonyl)-

CAY10602 HCl

Inhibitor,CAY 10602,CAY10602,CAY-10602,inhibit,Sirtuin

CAY10602, SIRT1 Activator

1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine/CAY10602

CAY10602, 10 mM in DMSO

SIRT1 Activator II

374922-43-7