CAY10602
- Product Name
- CAY10602
- CAS No.
- 374922-43-7
- Chemical Name
- CAY10602
- Synonyms
- CAY10602;CAY10602 HCl;CAY10602, >98%;SIRT1 Activator II;CAY10602, 10 mM in DMSO;CAY10602, SIRT1 Activator;SIRT1 Activator II - CAS 374922-43-7 - Calbiochem;Inhibitor,CAY 10602,CAY10602,CAY-10602,inhibit,Sirtuin;1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine;1H-Pyrrolo[2,3-b]quinoxalin-2-amine, 1-(4-fluorophenyl)-3-(phenylsulfonyl)-
- CBNumber
- CB12590438
- Molecular Formula
- C22H15FN4O2S
- Formula Weight
- 418.44
- MOL File
- 374922-43-7.mol
CAY10602 Property
- Melting point:
- 270 °C
- storage temp.
- +2C to +8C
- solubility
- DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
- form
- Off-white powder
- color
- Light yellow to Amber to Dark green
- CAS DataBase Reference
- 374922-43-7
Safety
- HS Code
- 2933.99.8290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 566313
- Product name
- SIRT1 Activator II - CAS 374922-43-7 - Calbiochem<br />The SIRT1 Activator II, also referenced under CAS 374922-43-7, modulates the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Biochemicals applications.
- Packaging
- 10mg
- Price
- $110
- Updated
- 2025/07/31
- Product number
- F1204
- Product name
- 1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
- Packaging
- 10MG
- Price
- $82
- Updated
- 2025/07/31
- Product number
- F1204
- Product name
- 1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
- Packaging
- 50MG
- Price
- $303
- Updated
- 2025/07/31
- Product number
- 10009796
- Product name
- CAY10602
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 10009796
- Product name
- CAY10602
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $56
- Updated
- 2024/03/01
CAY10602 Chemical Properties,Usage,Production
Uses
CAY10602 is a SIRT1 activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells[1].
General Description
A cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator (10 μM causes ~2.3-fold fluorescent enhancement in a fluorescent assay using hrSIRT1) and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. Shown to inhibit LPS-induced TNF-α release in THP-1 cells by ~10-fold more potent than resveratrol (Cat. No. 554325).
IC 50
SIRT1
References
[1] Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11(8):959-67. DOI:10.1177/1087057106294710
CAY10602 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10602 Suppliers
- Tel
- --
- Fax
- --
- sales-in@tcichemicals.com
- Country
- India
- ProdList
- 6768
- Advantage
- 58