4-chloro-7-Methoxyquinoline-6-carboxaMide

Product Name: 4-chloro-7-Methoxyquinoline-6-carboxaMide
CAS No.: 417721-36-9
Chemical Name: 4-chloro-7-Methoxyquinoline-6-carboxaMide
Synonyms: lenvaint-E;synthesis-024;synthesis-1-014;ine-6-carboxamide;oro-7-methoxyquinoL;Lenvatinib Impurity b;Lenvatinib Impurity 50;Lenvatinib Impurity LFS-B;4-chloro-7-Methoxy-6-QuinolinecarboxaMide;4-chloro-7-Methoxyquinoline-6-carboxaMide
CBNumber: CB12596687
Molecular Formula: C11H9ClN2O2
Formula Weight: 236.65
MOL File: 417721-36-9.mol

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4-chloro-7-Methoxyquinoline-6-carboxaMide Property

Melting point:: >205°C (dec.)
Boiling point:: 426.7±45.0 °C(Predicted)
Density: 1.380±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 15.28±0.30(Predicted)
form: Solid
color: Off-White to Light Beige
InChI: InChI=1S/C11H9ClN2O2/c1-16-10-5-9-6(4-7(10)11(13)15)8(12)2-3-14-9/h2-5H,1H3,(H2,13,15)
InChIKey: ZBTVNIDMGKZSGC-UHFFFAOYSA-N
SMILES: N1C2C(=CC(C(N)=O)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference: 417721-36-9

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C369515
Product name: 4-Chloro-7-methoxy-6-quinolinecarboxamide
Packaging: 1g
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC158634
Product name: 4-Chloro-7-methoxyquinoline-6-carboxamide
Packaging: 2g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC158634
Product name: 4-Chloro-7-methoxyquinoline-6-carboxamide
Packaging: 500mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR53151
Product name: 4-Chloro-7-methoxyquinoline-6-carboxamide
Purity: 97%
Packaging: 5g
Price: $145
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-5-C6
Product name: 4-Chloro-7-methoxyquinoline-6-carboxamide
Purity: 97%
Packaging: 5G
Price: $160
Updated: 2021/12/16

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4-chloro-7-Methoxyquinoline-6-carboxaMide Chemical Properties,Usage,Production

Description

4-chloro-7-Methoxyquinoline-6-carboxaMide is a pharmaceutical intermediate compound used in the preparation of Lenvatinib, an oral multi-receptor tyrosine kinase inhibitor approved by the FDA for the treatment of radioiodine-refractory differentiated thyroid cancer (DTC), unresectable (DTC), unresectable hepatocellular carcinoma (HCC), and advanced renal cell carcinoma (RCC).

Chemical Properties

light yellow powder

Uses

Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.

4-chloro-7-Methoxyquinoline-6-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-7-Methoxyquinoline-6-carboxaMide Suppliers

China 340 India 5 United Kingdom 3 United States 8 Global 356

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Syncozymes (Shanghai) Co.,Ltd.

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View Lastest Price from 4-chloro-7-Methoxyquinoline-6-carboxaMide manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 4-chloro-7-Methoxyquinoline-6-carboxaMide 417721-36-9
Price: US $1.00-0.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2023-12-11

Hangzhou ICH Biofarm Co., Ltd

Product: 4-Chloro-7-Methoxyquinoline-6-Carboxamide 417721-36-9
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2024-12-26

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 4-chloro-7-methoxyquinoline-6-carboxamide 417721-36-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥98% by HPLC
Supply Ability: 20kg/month
Release date: 2023-01-05

417721-36-9, 4-chloro-7-Methoxyquinoline-6-carboxaMideRelated Search:

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4-chloro-7-Methoxyquinoline-6-carboxaMide

4-chloro-7-Methoxy-6-QuinolinecarboxaMide

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Lenvatinib Impurity LFS-B

synthesis-024

4-Chloro-7-methoxy-quinoline-6-carboxylic acid amide

4-Chloro-7-methoxyquinazoline-6-carboxamide

lenvaint-E

ine-6-carboxamide

oro-7-methoxyquinoL

synthesis-1-014

Lenvatinib Impurity 50

417721-36-9

477721-36-9

Intermediate

417721-36-9