2-CHLORO-4-SULFAMOYLANILINE
- Product Name
- 2-CHLORO-4-SULFAMOYLANILINE
- CAS No.
- 53297-68-0
- Chemical Name
- 2-CHLORO-4-SULFAMOYLANILINE
- Synonyms
- Diazoxide Impurity 11;2-CHLORO-4-SULFAMOYLANILINE;Hydrochlorothiazide Impurity 71;4-amino-3-chlorobenzenesulfonamide;4-amino-3-chloro-benzenesulfonamid;Benzenesulfonamide, 4-amino-3-chloro-;4-amino-3-chlorobenzene-1-sulfonamide;3-14-00-02189 (Beilstein Handbook Reference)
- CBNumber
- CB1261277
- Molecular Formula
- C6H7ClN2O2S
- Formula Weight
- 206.65
- MOL File
- 53297-68-0.mol
2-CHLORO-4-SULFAMOYLANILINE Property
- Melting point:
- 161 °C
- Boiling point:
- 414.4±55.0 °C(Predicted)
- Density
- 1.558±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 9.83±0.60(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H7ClN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11)
- InChIKey
- LFIOFZKZCDMGFG-UHFFFAOYSA-N
- SMILES
- C1(S(N)(=O)=O)=CC=C(N)C(Cl)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS007881
- Product name
- 2-chloro-4-sulfamoylaniline
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $216
- Updated
- 2025/07/31
- Product number
- C428993
- Product name
- 2-Chloro-4-sulfamoylaniline
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 0225CG
- Product name
- 4-Amino-3-chlorobenzenesulfonamide
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- HCH0019246
- Product name
- 2-CHLORO-4-SULFAMOYLANILINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $837.99
- Updated
- 2021/12/16
- Product number
- 0225CG
- Product name
- 4-Amino-3-chlorobenzenesulfonamide
- Packaging
- 1g
- Price
- $261
- Updated
- 2021/12/16
2-CHLORO-4-SULFAMOYLANILINE Chemical Properties,Usage,Production
Uses
2-Chloro-4-sulfamoylanilide is an organic compound commonly used as a synthetic intermediate, especially in the synthesis of pharmaceuticals, pesticides and dyes.
Synthesis
63-74-1
53297-68-0
The general procedure for the synthesis of 4-amino-3-chlorobenzenesulfonamide from crystalline sulfonamide was as follows: 1 mmol of sulfonamide was dissolved in 12 mL of tetrahydrofuran under anhydrous and anaerobic conditions. Subsequently, 2 mmol of N-chlorosuccinimide (NCS) powder was added, and the reaction mixture was stirred at 40 °C for 25 hours. After completion of the reaction, the solvent was evaporated by rotary evaporator. The residue was extracted with 30 mL of ethyl acetate. The organic layer was washed sequentially with 5 mL of saturated potassium carbonate solution and 5 mL of saturated sodium chloride solution. The washed organic layer was dried with anhydrous sodium sulfate, filtered and purified by column chromatography (eluent ratio of dichloromethane: ethyl acetate = 7:1). Finally, 188 mg of the light yellow powdery product 4-amino-3-chlorobenzenesulfonamide was obtained in 95% yield.
References
[1] Patent: CN107400060, 2017, A. Location in patent: Paragraph 0011; 0029; 0030; 0036; 0037; 0043-0044; 0050-0051
[2] Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1988, vol. 27, # 12, p. 1028 - 1030
2-CHLORO-4-SULFAMOYLANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-4-SULFAMOYLANILINE manufacturers
- Product
- 2-Chloro-4-sulfamoylaniline 53297-68-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%HPLC
- Supply Ability
- 5ton
- Release date
- 2023-11-29
- Product
- 2-CHLORO-4-SULFAMOYLANILINE 53297-68-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08