ChemicalBook > CAS DataBase List > [S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride

[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride

Product Name
[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride
CAS No.
1243259-19-9
Chemical Name
[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride
Synonyms
LM11A-31;LM11A-31 BHS;LM11A-31 HCl;LM11A 31 2HCl;(2S,3S)-2-AMINO-3-;LM11A-31 (hydrochloride);LM11A-31 D8 dihydrochloride;LM11A-31 dihydrochloride salt;LM11A-31, nonpeptide p75NTR ligand;LM11A-31 dihydrochloride (LM11A-31 BHS)
CBNumber
CB12621190
Molecular Formula
C12H26ClN3O2
Formula Weight
279.81
MOL File
1243259-19-9.mol
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[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Property

Melting point:
>68°C (dec.)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 30 mg/ml)
form 
solid
color 
Pale yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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Safety

HS Code 
9999999999
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21982
Product name
LM11A-31 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
21982
Product name
LM11A-31 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
21982
Product name
LM11A-31 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
21982
Product name
LM11A-31 (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$268
Updated
2024/03/01
TRC
Product number
A612500
Product name
(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamideHydrochloride
Packaging
50mg
Price
$90
Updated
2021/12/16
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[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Chemical Properties,Usage,Production

Description

LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand that inhibits nerve growth factor (NGF) binding to p75NTR-Fc (A2 = 1,192 nM). It inhibits DNA damage in and promotes survival of hippocampal neuronal cultures in a p75NTR- and concentration-dependent manner. LMA11A-31 also inhibits proNGF-induced cell death of mature oligodendrocytes. In vivo, LMA11A-31 (10-100 mg/kg) improves motor function and coordination in the weight-bearing open-field test and nonweight-bearing swim test and increases survival of oligodendrocytes in a mouse model of spinal contusion injury. It prevents and/or reverses atrophy of forebrain cholinergic neurites and cortical dystrophic neurites in Thy-1 hAPPLond/Swe and Tg2576 mice with mid- to late stage Alzheimer''s disease. It also reduces excessive alcohol self-administration in rats and decreases huntingtin (Htt) aggregate formation and striatal cholinergic degeneration in the R6/2 mouse model of Huntington''s disease.

Uses

(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide is used for the preparation of peptideamides for treatment of retroviral infection.

storage

Desiccate at RT

References

1) Massa?et al. (2006),?Small, Nonpeptide p75NTR Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death; J. Neurosci.?26?5288 2) Tep?et al., (2013),?Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury; J. Neurosci.?33?397 3) Shi?et al. (2013),?A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury; Stem Cells?31?2561 4) Simmons?et al.?(2014),?A small molecule p75(NTR) ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models with mid- to late-stage disease progression; PLoS One?9?e102136 5) Meeker?et al.?(2016),?Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis; Exp. Neurol.?275?Pt.1 182

[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride Suppliers

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View Lastest Price from [S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride manufacturers

Career Henan Chemical Co
Product
[S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride 1243259-19-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-18

1243259-19-9, [S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide DihydrochlorideRelated Search:

Erlotinib hydrochloride 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE TYRPHOSTIN AG 879 LM 22A4

  • (2S,3S)-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Hydrochloride
  • [S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride
  • (2S,3S)-2-AMINO-3-METHYL-N-(2-MORPHOLIN-4-YLETHYL)PENTANAMIDE
  • LM11A-31
  • Pentanamide, 2-amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-, hydrochloride (1:2), (2S,3S)-
  • LM11A-31 (hydrochloride)
  • (2S,3S)-2-Amino-3-methyl-N-(2-morpholinoethyl)pentanamide Dihydrochloride
  • LM11A-31 dihydrochloride (LM11A-31 BHS)
  • (2S,3S)-2-amino-3-methyl-N-(2-morpholinoethyl)pentanamide hydrochloride
  • (2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride
  • LM11A-31 BHS
  • LM11A 31 2HCl
  • LM11A-31 D8 dihydrochloride
  • [S-(R*,R*)]-2-AMino-3-Methyl-N-[2-(4-Morpholinyl)ethyl]pentanaMide Dihydrochloride ISO 9001：2015 REACH
  • LM11A-31 dihydrochloride salt
  • (2S,3S)-2-AMINO-3-
  • LM11A-31 HCl
  • cholinergic,proNGF,Inhibitor,inhibit,growth,dystrophy,disease,p75,Neurotensin Receptor,LM-11A-31 dihydrochloride,nerve,neurite,receptor,barrier,neurotrophin,LM11A-31,factor,Ligand,LM11A 31 dihydrochloride,blood-brain,LM11A31 dihydrochloride,Alzheimer's,p75NTR
  • LM11A-31, nonpeptide p75NTR ligand
  • 1243259-19-9
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  • Amino Acids & Derivatives, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals