LM 22A4
- Product Name
- LM 22A4
- CAS No.
- 37988-18-4
- Chemical Name
- LM 22A4
- Synonyms
- BD2-4;LM 22A4;LM22A-4 ，S0827;LM 22A4; LM 22A-4;LM22A-4 - Bio-X ?;LM22A-4, 10 mM in DMSO;LM22A-4, neurotrophic BDNF mimetic;N,N',N''-Tris(beta-hydroxyethyl)trimesamide;N1,N3,N5-Tris(2-hydroxyethyl)benzene-1,3,5-tricarboxamide;N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
- CBNumber
- CB32682689
- Molecular Formula
- C15H21N3O6
- Formula Weight
- 339.34
- MOL File
- 37988-18-4.mol
LM 22A4 Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble2mg/mL, clear (warmed)
- form
- powder
- color
- white to beige
- Water Solubility
- H2O: 2mg/mL, clear (warmed)
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0848
- Product name
- LM22A-4
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $122
- Updated
- 2025/07/31
- Product number
- SML0848
- Product name
- LM22A-4
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $397
- Updated
- 2025/07/31
- Product number
- 22082
- Product name
- LM22A-4
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 22082
- Product name
- LM22A-4
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 22082
- Product name
- LM22A-4
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $254
- Updated
- 2024/03/01
LM 22A4 Chemical Properties,Usage,Production
Description
LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1?Improves respiratory function in a mouse models of Rett syndrome.2
Uses
LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. LM 22A4 has been show to induce activation of Trk, Akt and ERK in mouse hippocampus and striatum and reverse deficits in motor task learning in mice following traumatic brain injury. LM 22A4 also restored respiratory function in a rat model of Rett syndrome.
in vivo
LM22A-4 (10 mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10 mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration (10 mg/kg) significantly improves the neurological scores compared with those of the solvent-treated animals[1].
storage
Store at +4°C
References
[1] STEPHEN M MASSA. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.[J]. The Journal of clinical investigation, 2010: 1774-1785. DOI:10.1172/jci41356
[2] DANIELLE A SCHMID. A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.[J]. Journal of Neuroscience, 2012, 32 5: 1803-1810. DOI:10.1523/jneurosci.0865-11.2012
LM 22A4 Preparation Products And Raw materials
Raw materials
Preparation Products
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