LM 22A4

Product Name: LM 22A4
CAS No.: 37988-18-4
Chemical Name: LM 22A4
Synonyms: BD2-4;LM 22A4;LM 22A4; LM 22A-4;N,N',N''-Tris(beta-hydroxyethyl)trimesamide;N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide;1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)-;1-N,3-N,5-N-TRIS(2-HYDROXYETHYL)BENZENE-1,3,5-TRICARBOXAMIDE;LM-22A-4,Inhibitor,Trk Receptor,inhibit,LM22A4,LM22A-4,Tropomyosin related kinase receptor,LM22A 4
CBNumber: CB32682689
Molecular Formula: C15H21N3O6
Formula Weight: 339.34
MOL File: 37988-18-4.mol

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LM 22A4 Property

storage temp.: 2-8°C
solubility: H2O: soluble2mg/mL, clear (warmed)
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0848
Product name: LM22A-4
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $71.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0848
Product name: LM22A-4
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $386
Updated: 2024/03/01

Cayman Chemical

Product number: 22082
Product name: LM22A-4
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 22082
Product name: LM22A-4
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 22082
Product name: LM22A-4
Purity: ≥98%
Packaging: 25mg
Price: $254
Updated: 2024/03/01

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LM 22A4 Chemical Properties,Usage,Production

Description

LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1?Improves respiratory function in a mouse models of Rett syndrome.2

Uses

LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. LM 22A4 has been show to induce activation of Trk, Akt and ERK in mouse hippocampus and striatum and reverse deficits in motor task learning in mice following traumatic brain injury. LM 22A4 also restored respiratory function in a rat model of Rett syndrome.

storage

Store at +4°C

References

1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774 2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803

LM 22A4 Preparation Products And Raw materials

Raw materials

Preparation Products

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LM 22A4 Suppliers

China 48 India 2 United Kingdom 2 United States 14 USA 1 Global 67

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
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Shanghai Leto Pharmatech Co.,Ltd.

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HangZhou YuHao Chemical Technology Co., Ltd.

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AdooQ Bioscience CHINA

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Email: info@adooq.cn
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Shanghaizehan biopharma technology co., Ltd.

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EMMX Biotechnology LLC

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Pharmacodia (Beijing) Co.,Ltd

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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37988-18-4, LM 22A4Related Search:

Gefitinib Hydroxychloroquine sulfate ZM 306416 hydrochloride SU 4312

LM 22A4

N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide

1-N,3-N,5-N-TRIS(2-HYDROXYETHYL)BENZENE-1,3,5-TRICARBOXAMIDE

BD2-4

N,N',N''-Tris(beta-hydroxyethyl)trimesamide

LM 22A4; LM 22A-4

1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)-

LM-22A-4,Inhibitor,Trk Receptor,inhibit,LM22A4,LM22A-4,Tropomyosin related kinase receptor,LM22A 4

37988-18-4

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