ChemicalBook > CAS DataBase List > LM 22A4

LM 22A4

Product Name
LM 22A4
CAS No.
37988-18-4
Chemical Name
LM 22A4
Synonyms
BD2-4;LM 22A4;LM 22A4; LM 22A-4;N,N',N''-Tris(beta-hydroxyethyl)trimesamide;N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide;1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)-;1-N,3-N,5-N-TRIS(2-HYDROXYETHYL)BENZENE-1,3,5-TRICARBOXAMIDE;LM-22A-4,Inhibitor,Trk Receptor,inhibit,LM22A4,LM22A-4,Tropomyosin related kinase receptor,LM22A 4
CBNumber
CB32682689
Molecular Formula
C15H21N3O6
Formula Weight
339.34
MOL File
37988-18-4.mol
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LM 22A4 Property

storage temp. 
2-8°C
solubility 
H2O: soluble2mg/mL, clear (warmed)
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0848
Product name
LM22A-4
Purity
≥98% (HPLC)
Packaging
5mg
Price
$71.4
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0848
Product name
LM22A-4
Purity
≥98% (HPLC)
Packaging
25mg
Price
$386
Updated
2024/03/01
Cayman Chemical
Product number
22082
Product name
LM22A-4
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
22082
Product name
LM22A-4
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
22082
Product name
LM22A-4
Purity
≥98%
Packaging
25mg
Price
$254
Updated
2024/03/01
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LM 22A4 Chemical Properties,Usage,Production

Description

LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1?Improves respiratory function in a mouse models of Rett syndrome.2

Uses

LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. LM 22A4 has been show to induce activation of Trk, Akt and ERK in mouse hippocampus and striatum and reverse deficits in motor task learning in mice following traumatic brain injury. LM 22A4 also restored respiratory function in a rat model of Rett syndrome.

storage

Store at +4°C

References

1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774 2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803

LM 22A4 Preparation Products And Raw materials

Raw materials

Preparation Products

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LM 22A4 Suppliers

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37988-18-4, LM 22A4Related Search:

Gefitinib Hydroxychloroquine sulfate ZM 306416 hydrochloride SU 4312

  • LM 22A4
  • N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
  • 1-N,3-N,5-N-TRIS(2-HYDROXYETHYL)BENZENE-1,3,5-TRICARBOXAMIDE
  • BD2-4
  • N,N',N''-Tris(beta-hydroxyethyl)trimesamide
  • LM 22A4; LM 22A-4
  • 1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)-
  • LM-22A-4,Inhibitor,Trk Receptor,inhibit,LM22A4,LM22A-4,Tropomyosin related kinase receptor,LM22A 4
  • 37988-18-4
  • Agonist, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals