ChemicalBook > CAS DataBase List > PropylsulfaMide
PropylsulfaMide
Uses- Product Name
- PropylsulfaMide
- CAS No.
- 147962-41-2
- Chemical Name
- PropylsulfaMide
- Synonyms
- N-PropylsulfaMide;(N-propylsulfamoyl)amide;PropylsulfaMide;SulfaMide, propyl-;SulfaMide, N-propyl-;Macetetan impurity 7;N-(1-propyl)sulfamide;Macitentan Impurity 50;Propylamino sulfonamide;N-Propylsulfuric diamide
- CBNumber
- CB12624267
- Molecular Formula
- C3H10N2O2S
- Formula Weight
- 138.19
- MOL File
- 147962-41-2.mol
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PropylsulfaMide Property
- Boiling point:
- 249.0±23.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.06±0.60(Predicted)
- form
- solid
- Appearance
- Colorless to off-white Solid
- InChI
- InChI=1S/C3H10N2O2S/c1-2-3-5-8(4,6)7/h5H,2-3H2,1H3,(H2,4,6,7)
- InChIKey
- FEYGBGVBTKYFOF-UHFFFAOYSA-N
- SMILES
- S(NCCC)(N)(=O)=O
- CAS DataBase Reference
- 147962-41-2
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
TRC
- Product number
- P838558
- Product name
- N-Propylsulfamide
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
AK Scientific
- Product number
- 3980AH
- Product name
- Propylsulfamide
- Packaging
- 5g
- Price
- $101
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M1494
- Product name
- Propylsulfamide
- Packaging
- 25g
- Price
- $319
- Updated
- 2021/12/16
AK Scientific
- Product number
- 3980AH
- Product name
- Propylsulfamide
- Packaging
- 25g
- Price
- $384
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M1494
- Product name
- Propylsulfamide
- Packaging
- 10g
- Price
- $157
- Updated
- 2021/12/16
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PropylsulfaMide Chemical Properties,Usage,Production
Uses
Propylamine sulfonamide is mainly used in pharmaceutical intermediates.
Synthesis
107-10-8
1189-71-5
147962-41-2
The general procedure for the synthesis of N-propylsulfonamide from n-propylamine and chlorosulfonyl isocyanate is as follows: first, chlorosulfonyl isocyanate (12.3 mL, 0.14 mol, 1.0 eq.) was slowly added to a solution of benzyl alcohol (14.7 mL, 0.14 mol, 1.0 eq.) in dichloromethane (DCM, 130 mL) at -35 °C over a reaction time of 30 min. . Subsequently, a solution of n-propylamine (14 mL, 0.17 mol, 1.2 eq.) and triethylamine (29.5 mL, 0.21 mol, 1.5 eq.) in DCM (35 mL) was added slowly and dropwise at -50 °C. The reaction time was 30 minutes. The reaction mixture was gradually warmed to 20 °C and kept at this temperature for 2 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with water, 33% HCl and water. The mixture was then warmed up to 30 °C and the organic and aqueous layers were separated. The organic layer was washed with a mixture of triethylamine (20 mL, 0.14 mol, 1 eq.) and water (50 mL) and the pH was adjusted to be greater than 5. Next, tetrahydrofuran (THF, 85 mL) and 10% Pd/C catalyst (1 g) were added and the hydrogenation reaction was carried out for 6 hr at 25 °C under a pressure of 6 bar hydrogen. At the end of the reaction, the catalyst was removed by Celite filtration. Subsequently, the volatile solvent was removed under reduced pressure and dimethyl sulfoxide (DMSO, 120 mL) was added to dissolve the product. The resulting DMSO solution of propane-1-sulfonamide (100% theoretical yield) was used directly in the next step of the reaction.
References
[1] Patent: WO2015/4265, 2015, A1. Location in patent: Page/Page column 25; 26
PropylsulfaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PropylsulfaMide manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- N-propylsulfamide;propylsulfamide 147962-41-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- N-propylsulfamide;propylsulfamide 147962-41-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
Career Henan Chemical Co
- Product
- PropylsulfaMide 147962-41-2
- Price
- US $100.00/KG
- Min. Order
- 100G
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-07-25
147962-41-2, PropylsulfaMideRelated Search:
Macitidine related impurities
CarbaMic acid, N-[(propylaMino)sulfonyl]-, phenylMethyl ester
5-(4-Bromophenyl)-4,6-dichloropyrimidine
2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER
4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy-
N-Propylsulfuric diamide-sodium
SulfaMide, N-propyl-,(potassiuM salt)(1:1)
Macitentan impurity A
5-Bromo-2-chloropyrimidine
Macitentan impurity B
macitentan
Dichloromethane
Macitentan IMpurity
Masitatin impurity 1
NA
Masitatin impurity 3
Macitidine impurity 2
Macitidine impurity 5