ChemicalBook > CAS DataBase List > CEP-32496 (free base)

CEP-32496 (free base)

Product Name
CEP-32496 (free base)
CAS No.
1188910-76-0
Chemical Name
CEP-32496 (free base)
Synonyms
CS-1683;AC013773;RXDX-105;AC 013773;Agerafenib;RXDX-105 (CEP-32496);CEP-32496 (free base);AC-013773. Agerafenib;Agerafenib (RXDX-105);Agerafenib (CEP-32496)
CBNumber
CB12627682
Molecular Formula
C24H22F3N5O5
Formula Weight
517.46
MOL File
1188910-76-0.mol
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CEP-32496 (free base) Property

storage temp. 
Store at -20°C
solubility 
≥25.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
A crystalline solid
color 
White to off-white
CAS DataBase Reference
1188910-76-0
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18776
Product name
CEP-32496
Purity
≥95%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18776
Product name
CEP-32496
Purity
≥95%
Packaging
1mg
Price
$74
Updated
2024/03/01
Cayman Chemical
Product number
18776
Product name
CEP-32496
Purity
≥95%
Packaging
5mg
Price
$299
Updated
2024/03/01
Cayman Chemical
Product number
18776
Product name
CEP-32496
Purity
≥95%
Packaging
10mg
Price
$381
Updated
2024/03/01
TRC
Product number
C256660
Product name
CEP32496
Packaging
75mg
Price
$1460
Updated
2021/12/16
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CEP-32496 (free base) Chemical Properties,Usage,Production

Description

B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. CEP-32496 is a potent inhibitor of B-RafV600E (Kd = 14 nM in an in vitro binding assay). It blocks B-RafV600E-dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC50s = 78 and 60 nM, respectively). CEP-32496 binds kinases other than B-Raf but displays selective cytotoxicity for cells expressing B-RafV600E. It displays good oral bioavailability in rats, dogs, and monkeys and has single oral dose pharmacodynamics inhibition of both pMEK and pERK in B-RafV600E colon carcinoma xenografts in nude mice.

Uses

CEP 32496 is an orally active BRAFV600E inhibitor with selective cellular and in vivo antitumor activity.

References

[1] rowbottom mw1, faraoni r, chao q, campbell bt, lai ag, setti e, ezawa m, sprankle kg, abraham s, tran l, struss b, gibney m, armstrong rc,gunawardane rn, nepomuceno rr, valenta i, hua h, gardner mf, cramer md, gitnick d, insko de, apuy jl, jones-bolin s, ghose ak, herbertz t, ator ma,dorsey bd, ruggeri b, williams m, bhagwat s, james j, holladay mw. identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2 -methylpropan- 2-yl) isoxazol-3-yl) urea hydrochloride (cep-32496), a highly potent and orally efficacious inhibitor of v-raf murine sarcoma viral oncogene homologue b1 (braf) v600e. j med chem. 2012 feb 9;55(3):1082-105. doi: 10.1021/jm2009925. epub 2012 jan 23.

CEP-32496 (free base) Preparation Products And Raw materials

Raw materials

Preparation Products

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CEP-32496 (free base) Suppliers

China 84 India 2 United States 16 Global 102
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
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58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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58
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
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64
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
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View Lastest Price from CEP-32496 (free base) manufacturers

Career Henan Chemical Co
Product
CEP-32496 (free base) 1188910-76-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-24

1188910-76-0, CEP-32496 (free base)Related Search:

SB590885

  • CEP-32496 (free base)
  • 1-[3-[(6,7-Dimethoxyquinazolin-4-yl)oxy]phenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl]urea
  • Urea, N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-
  • AC 013773
  • AC013773
  • AC-013773. Agerafenib
  • CEP-32496 FREE BASE;AC013773; AC 013773; AC-013773. AGERAFENIB
  • 1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea
  • Agerafenib (CEP-32496)
  • CEP-32496;CEP 32496;CEP32496
  • CS-1683
  • Agerafenib
  • RXDX-105
  • RXDX-105 (CEP-32496)
  • CEP-32496 CEP32496 Agerafenib RXDX-105 RXDX105
  • Agerafenib (RXDX-105)
  • Agerafenib, 10 mM in DMSO
  • 1188910-76-0
  • 188910-76-0
  • Inhibitors
  • MAPK