Genz644282

ChemicalBook > CAS DataBase List > Genz644282

Uses

Product Name: Genz644282
CAS No.: 529488-28-6
Chemical Name: Genz644282
Synonyms: CS-1079;GNZ-644282;Genz644282;GNZ-644282cas;GENZ644282; GENZ 644282;GENZ-644282;GENZ644282;GENZ 644282;Genz 644282,Inhibitor,inhibit,Genz-644282,Topoisomerase;8,9-dimethoxy-2,3-methylenedioxy-5-[2-(N-methylamino)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one;2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one;Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 2,3-dimethoxy-12-[2-(methylamino)ethyl]-
CBNumber: CB12627899
Molecular Formula: C22H21N3O5
Formula Weight: 407.42
MOL File: 529488-28-6.mol

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Genz644282 Property

Melting point:: 254-257℃ (Decomposition)
Boiling point:: 665.5±55.0 °C(Predicted)
Density: 1.344±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly)
form: Solid
pka: 9.59±0.10(Predicted)
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24193
Product name: Genz-644282
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 24193
Product name: Genz-644282
Purity: ≥98%
Packaging: 5mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 24193
Product name: Genz-644282
Purity: ≥98%
Packaging: 10mg
Price: $351
Updated: 2024/03/01

Cayman Chemical

Product number: 24193
Product name: Genz-644282
Purity: ≥98%
Packaging: 25mg
Price: $728
Updated: 2024/03/01

TRC

Product number: G367760
Product name: GENZ-644282
Packaging: 50mg
Price: $1215
Updated: 2021/12/16

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Genz644282 Chemical Properties,Usage,Production

Uses

GENZ-644282 is used in the synthesis of ARC-111 analogs in the improvement of the antitumor activity of the parent compound.

Uses

GENZ-644282 is used in the synthesis of ARC-111 analogs in the improvement of the antitumor activity of the parent compound.

Biological Activity

genz-644282 [8,9-dimethoxy-5-(2-n-methylaminoethyl)-2,3-methylenedioxy-5h-dibenzo[c,h][1,6]naphthyridin-6-one] has emerged as a promising candidate of non-camptothecin topoisomerase i inhibitor for antitumor agents.

in vitro

genz-644282 demonstrated potent cytotoxic activity with a median ic(50) of 1.2 nm (range 0.2-21.9 nm) [1]. limited cross-resistance to genz-644282 was also found in the top1 knockdown colon cancer (hct116) and breast cancer (mcf7) cell lines and in human adenocarcinoma cells (kb31/kbv1) that overexpress (p-glycoprotein, abcb1), a member of the atp-binding cassette family of cell surface transport proteins known to confer mdr [3].

in vivo

genz-644282 at its mtd (4 mg/kg) induced maintained complete responses (mcr) in 6/6 evaluable solid tumor models. at 2 mg/kg genz-644282 induced cr or mcr in 3/3 tumor models relatively insensitive to topotecan, but there were no objective responses at 1 mg/kg [1]. genz-644282 was tolerated at doses up to 4 mg/kg when administered intravenously on alternate days, and the compound was active at doses from 1 to 4 mg/kg. the efficacy of genz-644282 was compared with irinotecan in 4 human colon carcinoma xenograft models. in the human hct-116 colon cancer xenograft, tgd values were 14 days for irinotecan (60 mg/kg) and 34 days for genz-644282 (2.7 mg/kg), giving maximum test to control ratios (t/cs) of 23.7% and 16.8%, respectively [2].

IC 50

1.2 nm [1]

Genz644282 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Genz644282 manufacturers

Career Henan Chemical Co

Product: Genz644282 529488-28-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-10

529488-28-6, Genz644282Related Search:

Eliglustat genz-682452

2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one

2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one GENZ-644282

GENZ-644282;GENZ644282;GENZ 644282

Genz644282

GNZ-644282

2,3-dimethoxy-12-(2-(methylamino)ethyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one

8,9-dimethoxy-2,3-methylenedioxy-5-[2-(N-methylamino)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

GENZ644282; GENZ 644282

CS-1079

Benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one, 2,3-dimethoxy-12-[2-(methylamino)ethyl]-

GNZ-644282cas

Genz 644282,Inhibitor,inhibit,Genz-644282,Topoisomerase

2,3-Dimethoxy-12-(2-(methylamino)ethyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one

16,17-dimethoxy-21-[2-(methylamino)ethyl]-5,7-dioxa-11,21-diazapentacyclo[11.8.0.02,1?.0?,?.01?,1?]henicosa-1(13),2(10),3,8,11,14(19),15,17-octaen-20-one

529488-28-6