genz-682452

Product Name: genz-682452
CAS No.: 1401090-53-6
Chemical Name: genz-682452
Synonyms: GZ-452;CS-2780;GZ402671;GZ-402671;SAR402671;Ibiglustat;SAR 402671;SAR-402671;genz-682452;GZ/SAR402671
CBNumber: CB23121975
Molecular Formula: C20H24FN3O2S
Formula Weight: 389.49
MOL File: 1401090-53-6.mol

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genz-682452 Property

Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:37.5(Max Conc. mg/mL);96.28(Max Conc. mM)
form: A crystalline solid
pka: 10.34±0.46(Predicted)
color: White to off-white
InChI: InChI=1S/C20H24FN3O2S/c1-20(2,17-12-27-18(22-17)14-3-5-15(21)6-4-14)23-19(25)26-16-11-24-9-7-13(16)8-10-24/h3-6,12-13,16H,7-11H2,1-2H3,(H,23,25)/t16-/m1/s1
InChIKey: YFHRCLAKZBDRHN-MRXNPFEDSA-N
SMILES: C(O[C@H]1C2CCN(CC2)C1)(=O)NC(C1=CSC(C2=CC=C(F)C=C2)=N1)(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301IF SWALLOWED:

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Crysdot

Product number: CD11264912
Product name: Ibiglustat
Purity: 97%
Packaging: 50mg
Price: $366
Updated: 2021/12/16

DC Chemicals

Product number: DC10007
Product name: Ibiglustat(Genz-682452）
Purity: >98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

Crysdot

Product number: CD11264912
Product name: Ibiglustat
Purity: 97%
Packaging: 250mg
Price: $1100
Updated: 2021/12/16

DC Chemicals

Product number: DC10007
Product name: Ibiglustat(Genz-682452）
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

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genz-682452 Chemical Properties,Usage,Production

Uses

Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease[1][2].

References

[1] Viel C, et al. Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model. Sci Rep. 2021;11(1):20945. Published 2021 Oct 22. DOI:10.1038/s41598-021-00404-5
[2] Peterschmitt MJ, et al. Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers. Clin Pharmacol Drug Dev. 2021;10(1):86-98. DOI:10.1002/cpdd.865
[3] Stojkovska I, et al. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease. Cell Tissue Res. 2018;373(1):51-60. doi:10.1007/s00441-017-2704-y DOI:10.1007/s00441-017-2704-y
[4] Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014 Nov;37(6):1013-22. DOI:10.1007/s10545-014-9724-5

genz-682452 Preparation Products And Raw materials

Raw materials

Preparation Products

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genz-682452 Suppliers

China 62 United States 8 Global 70

Shanghai Dongyang Biotechnology Co., Ltd.

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1401090-53-6, genz-682452Related Search:

Eliglustat Genz644282

GZ/SAR402671

IBIGLUSTAT;VENGLUSTAT;GZ/SAR402671;GZ402671;SAR402671

genz-682452

Ansofaxine Hydrochloride

Ibiglustat

(S)-QUINUCLIDIN-3-YL (2-(2-(4-FLUOROPHENYL)THIAZOL-4-YL)PROPAN-2-YL)CARBAMATE

Ibiglustat(Genz-682452)

Genz-682452-AA

GZ402671

GZ-402671

GZ-402671; GZ402671; GZ402671; SAR402671; SAR-402671; SAR 402671; GENZ-682452-AA; IBIGLUSTAT; GZ-452; GENZ-682452

GZ-452

CS-2780

SAR 402671

SAR402671

SAR-402671

Carbamic acid, N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-, (3S)-1-azabicyclo[2.2.2]oct-3-yl ester

Ibiglustat (Venglustat

oral,Parkinson's disease,GZ-402671,GZ 402671,Ibiglustat,inhibit,Inhibitor,SAR 402671,SAR-402671,GBA,Fabry disease,GL-3 levels,mutations

Venglustat (ibiglustat)

Ibiglustat, 10 mM in DMSO

1401090-53-6

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