JI-101
- Product Name
- JI-101
- CAS No.
- 900573-88-8
- Chemical Name
- JI-101
- Synonyms
- JI-101;CS-2268;CGI 1842;JI101;JI 101;JI-101, 10 mM in DMSO;Pazopanib Impurity 66;1-[1-[(2-Aminopyridin-4-yl)methyl]-1H-indol-4-yl]-3-(5-bromo-2-methoxyphenyl)urea;Urea, N-[1-[(2-amino-4-pyridinyl)methyl]-1H-indol-4-yl]-N'-(5-bromo-2-methoxyphenyl)-;5-amino-2-methyl-N-(4-methyl-3-(N-(4-methyl-3-sulfamoylphenyl)sulfamoyl)phenyl)benzenesulfonamide;Inhibitor,Vascular endothelial growth factor receptor,JI-101,Ephrin Receptor,PDGFR,JI101,VEGFR,Platelet-derived growth factor receptor,inhibit
- CBNumber
- CB12627990
- Molecular Formula
- C22H20BrN5O2
- Formula Weight
- 466.33
- MOL File
- 900573-88-8.mol
JI-101 Property
- Boiling point:
- 606.9±55.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 13.25±0.70(Predicted)
- color
- Pale Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- J210340
- Product name
- JI-101
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-5636
- Product name
- JI-101
- Purity
- 99.95%
- Packaging
- 10mg
- Price
- $228
- Updated
- 2021/12/16
- Product number
- CS-5636
- Product name
- JI-101
- Purity
- 99.95%
- Packaging
- 50mg
- Price
- $792
- Updated
- 2021/12/16
- Product number
- CS-5636
- Product name
- JI-101
- Purity
- 99.95%
- Packaging
- 100mg
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- CS-5636
- Product name
- JI-101
- Purity
- 99.95%
- Packaging
- 5mg
- Price
- $156
- Updated
- 2021/12/16
JI-101 Chemical Properties,Usage,Production
Uses
JI-?101 is VEGFR2 inhibitor. It can be used as analyte in pharmacological activity and analytical study of assay methodologies and perspectives for quantitation of VEGFR2 inhibitors such as sunitinib, sorafenib, pazopanib and JI-101 which were involved in treatment of cancer in human and animal models including mouse.
in vivo
JI-101excreted through bile along with its mono- and di-hydroxy metabolites. Following oral administration, JI-101 is rapidly absorbed, reaching Cmax within 2?h. The t1/2 of JI-101 with intravenous and oral route is found to be 1.75±0.79 and 2.66±0.13?h, respectively. The Cl and Vd by intravenous route for JI-101 are found to be 13.0±2.62?mL/min/kg and 2.11±1.42?L/kg, respectively. The tissue distribution of JI-101 is extensive with rapid and preferred uptake into lung tissue. Overall, the oral bioavailability of JI-101 is 55% and the primary route of elimination for JI-101 is feces[1].
IC 50
VEGFR2; PDGFRβ
JI-101 Preparation Products And Raw materials
Raw materials
Preparation Products
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