Temsavir
- Product Name
- Temsavir
- CAS No.
- 701213-36-7
- Chemical Name
- Temsavir
- Synonyms
- CS-1668;Temsavir;EOS-62215;BMS-626529;BMS 626529;BMS-626529, Temsavir;BMS 626529; BMS626529;Temsavir (BMS-626529);Foscarbidopa Impurity 13;(1R,2S,3R,6S,7S,10R)-10-ISOPROPYL-3,7-DIMETHYL-11-OXATRICYCLO[5.3.1.02,6]UNDECAN-3-OL
- CBNumber
- CB12645134
- Molecular Formula
- C24H23N7O4
- Formula Weight
- 473.48
- MOL File
- 701213-36-7.mol
Temsavir Property
- Melting point:
- 263-265°C
- Boiling point:
- 787.6±70.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.92±0.40(Predicted)
- color
- Off-White to Pale Beige
- InChI
- InChI=1S/C24H23N7O4/c1-15-27-14-31(28-15)22-20-19(18(35-2)13-26-22)17(12-25-20)21(32)24(34)30-10-8-29(9-11-30)23(33)16-6-4-3-5-7-16/h3-7,12-14,25H,8-11H2,1-2H3
- InChIKey
- QRPZBKAMSFHVRW-UHFFFAOYSA-N
- SMILES
- C(N1CCN(C(=O)C2=CC=CC=C2)CC1)(=O)C(C1C2C(OC)=CN=C(N3C=NC(C)=N3)C=2NC=1)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 18413
- Product name
- BMS 626529
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18413
- Product name
- BMS 626529
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 18413
- Product name
- BMS 626529
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $299
- Updated
- 2024/03/01
- Product number
- 18413
- Product name
- BMS 626529
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $849
- Updated
- 2024/03/01
- Product number
- T017900
- Product name
- Temsavir
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
Temsavir Chemical Properties,Usage,Production
Description
BMS 626529 is an inhibitor of HIV-1 attachment. It binds to non-ligand bound HIV-1 gp120 to inhibit HIV-1 interaction with host CD4+ T cells and subsequent HIV-1 binding and cell entry. BMS 626529 reduces infectivity of laboratory strains and clinical isolates of HIV-1 (EC50s = 0.4-2,000 and 25-2,000 nM, respectively) with cytotoxic concentration (CC50) values greater than 100 μM in a panel of mammalian cell lines.
Uses
Temsavir is a Fostemsavir (CAS# 864953-29-7) intermediate and an antiviral agent. It is an HIV-1 attachment inhibitor.
Uses
Temsavir is an FDA-approved HIV-1 adhesion inhibitor. It blocks the interaction of Env with CD4. This molecule also stabilises Env in a pre-fused 'closed' conformation, which is the preferred target of several broad-spectrum neutralising antibodies (bNAbs). temsavir treatment also reduces the ability of bNAbs to eliminate HIV-1 infected cells through antibody-dependent cellular cytotoxicity (ADCC). fostemsavir, a pre-drug of temsavir, was approved in the FDA on 2 July 2020 approved for the treatment of patients with multidrug-resistant HIV-1 infection.
brand name
BMS-626529
Biological Functions
Temsavir prevents the host cell receptor CD4 from interacting with Env by binding to the pocket under the gp120 β20-β21 ring of the Env subunit. It prevents viral entry and also stabilises Env in a 'closed' conformation[3].
in vitro
the activity of bms-626529 is virus dependent, due to heterogeneity within gp120. bms-626529 had half-maximal effective concentration values of6 log10, with half-maximal effective concentration values in the low pm range against the most susceptible viruses. measurement of the binding affinity of bms-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life [1].
target
HIV-1 subtype A envelope
References
[1] nowicka-sans b, gong yf, mcauliffe b, dicker i, ho ht, zhou n, eggers b, lin pf, ray n, wind-rotolo m, zhu l, majumdar a, stock d, lataillade m, hanna gj, matiskella jd, ueda y, wang t, kadow jf, meanwell na, krystal m. in vitro antiviral characteristics of hiv-1 attachment inhibitor bms-626529, the active component of the prodrug bms-663068. antimicrob agents chemother. 2012;56(7):3498-507.
[2] nettles re, schürmann d, zhu l, stonier m, huang sp, chang i, chien c, krystal m, wind-rotolo m, ray n, hanna gj, bertz r, grasela d. pharmacodynamics, safety, and pharmacokinetics of bms-663068, an oral hiv-1 attachment inhibitor in hiv-1-infected subjects. j infect dis. 2012;206(7):1002-11.
[3] MARIANNE BOUTIN. Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage.[J]. Viruses-Basel, 2023. DOI:10.3390/v15051189.
Temsavir Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Temsavir manufacturers
- Product
- BMS 626529 701213-36-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09