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Temsavir

Product Name
Temsavir
CAS No.
701213-36-7
Chemical Name
Temsavir
Synonyms
CS-1668;Temsavir;EOS-62215;BMS-626529;BMS 626529;BMS-626529, Temsavir;BMS 626529; BMS626529;Temsavir (BMS-626529);Foscarbidopa Impurity 13;(1R,2S,3R,6S,7S,10R)-10-ISOPROPYL-3,7-DIMETHYL-11-OXATRICYCLO[5.3.1.02,6]UNDECAN-3-OL
CBNumber
CB12645134
Molecular Formula
C24H23N7O4
Formula Weight
473.48
MOL File
701213-36-7.mol
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Temsavir Property

Melting point:
263-265°C
Boiling point:
787.6±70.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
10.92±0.40(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C24H23N7O4/c1-15-27-14-31(28-15)22-20-19(18(35-2)13-26-22)17(12-25-20)21(32)24(34)30-10-8-29(9-11-30)23(33)16-6-4-3-5-7-16/h3-7,12-14,25H,8-11H2,1-2H3
InChIKey
QRPZBKAMSFHVRW-UHFFFAOYSA-N
SMILES
C(N1CCN(C(=O)C2=CC=CC=C2)CC1)(=O)C(C1C2C(OC)=CN=C(N3C=NC(C)=N3)C=2NC=1)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18413
Product name
BMS 626529
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18413
Product name
BMS 626529
Purity
≥98%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
18413
Product name
BMS 626529
Purity
≥98%
Packaging
10mg
Price
$299
Updated
2024/03/01
Cayman Chemical
Product number
18413
Product name
BMS 626529
Purity
≥98%
Packaging
50mg
Price
$849
Updated
2024/03/01
TRC
Product number
T017900
Product name
Temsavir
Packaging
50mg
Price
$65
Updated
2021/12/16
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Temsavir Chemical Properties,Usage,Production

Description

BMS 626529 is an inhibitor of HIV-1 attachment. It binds to non-ligand bound HIV-1 gp120 to inhibit HIV-1 interaction with host CD4+ T cells and subsequent HIV-1 binding and cell entry. BMS 626529 reduces infectivity of laboratory strains and clinical isolates of HIV-1 (EC50s = 0.4-2,000 and 25-2,000 nM, respectively) with cytotoxic concentration (CC50) values greater than 100 μM in a panel of mammalian cell lines.

Uses

Temsavir is a Fostemsavir (CAS# 864953-29-7) intermediate and an antiviral agent. It is an HIV-1 attachment inhibitor.

Uses

Temsavir is an FDA-approved HIV-1 adhesion inhibitor. It blocks the interaction of Env with CD4. This molecule also stabilises Env in a pre-fused 'closed' conformation, which is the preferred target of several broad-spectrum neutralising antibodies (bNAbs). temsavir treatment also reduces the ability of bNAbs to eliminate HIV-1 infected cells through antibody-dependent cellular cytotoxicity (ADCC). fostemsavir, a pre-drug of temsavir, was approved in the FDA on 2 July 2020 approved for the treatment of patients with multidrug-resistant HIV-1 infection.

brand name

BMS-626529

Biological Functions

Temsavir prevents the host cell receptor CD4 from interacting with Env by binding to the pocket under the gp120 β20-β21 ring of the Env subunit. It prevents viral entry and also stabilises Env in a 'closed' conformation[3].

in vitro

the activity of bms-626529 is virus dependent, due to heterogeneity within gp120. bms-626529 had half-maximal effective concentration values of6 log10, with half-maximal effective concentration values in the low pm range against the most susceptible viruses. measurement of the binding affinity of bms-626529 for purified gp120 suggests that a contributory factor to its inhibitory potency may be a relatively long dissociative half-life [1].

target

HIV-1 subtype A envelope

References

[1] nowicka-sans b, gong yf, mcauliffe b, dicker i, ho ht, zhou n, eggers b, lin pf, ray n, wind-rotolo m, zhu l, majumdar a, stock d, lataillade m, hanna gj, matiskella jd, ueda y, wang t, kadow jf, meanwell na, krystal m.  in vitro antiviral characteristics of hiv-1 attachment inhibitor bms-626529, the active component of the prodrug bms-663068. antimicrob agents chemother. 2012;56(7):3498-507.
[2] nettles re, schürmann d, zhu l, stonier m, huang sp, chang i, chien c, krystal m, wind-rotolo m, ray n, hanna gj, bertz r, grasela d.  pharmacodynamics, safety, and pharmacokinetics of bms-663068, an oral hiv-1 attachment inhibitor in hiv-1-infected subjects. j infect dis. 2012;206(7):1002-11.
[3] MARIANNE BOUTIN. Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage.[J]. Viruses-Basel, 2023. DOI:10.3390/v15051189.

Temsavir Preparation Products And Raw materials

Raw materials

Preparation Products

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Temsavir Suppliers

Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
957
Advantage
58
Shanghai Taibao Pharmaceutical Technology Co., Ltd.
Tel
13816752554
Email
1745533547@qq.com
Country
China
ProdList
129
Advantage
58
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
5793
Advantage
58
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
595
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Shanghai Twisun Bio-pharm Co.,Ltd
Tel
+86-21-33282107
Fax
+86-21-37285115
Country
China
ProdList
107
Advantage
60
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View Lastest Price from Temsavir manufacturers

Career Henan Chemical Co
Product
BMS 626529 701213-36-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

701213-36-7, TemsavirRelated Search:


  • 1-Benzoyl-4-[[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]oxoacetyl]piperazine BMS626529
  • BMS 626529
  • BMS-626529
  • 1-Benzoyl-4-[[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]oxoacetyl]piperazine
  • Temsavir
  • 1-(4-benzoylpiperazin-1-yl)-2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione
  • (1R,2S,3R,6S,7S,10R)-10-ISOPROPYL-3,7-DIMETHYL-11-OXATRICYCLO[5.3.1.0<SUP>2,6</SUP>]UNDECAN-3-OL
  • 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-
  • EOS-62215
  • Temsavir (BMS-626529)
  • BMS 626529; BMS626529
  • BMS-626529, Temsavir
  • CS-1668
  • 1-(4-benzoylpiperazin-1-yl)-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1h-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione
  • Foscarbidopa Impurity 13
  • 701213-36-7
  • C24H23N7O4