Methyl L-histidinate dihydrochloride

Product Name: Methyl L-histidinate dihydrochloride
CAS No.: 7389-87-9
Chemical Name: Methyl L-histidinate dihydrochloride
Synonyms: L-His-OMeHCl;H-His-OMeHCl;L-His-OMe·2HCl;H-HIS-OME 2HCL;H-His-OMe.2HCI;H-L-HIS-OME 2HCL;ester dihydrochL;-Histidine methyL;HISTIDINE-OME 2 HCL;L-Histidine methyl e
CBNumber: CB1264687
Molecular Formula: C7H13Cl2N3O2
Formula Weight: 242.1
MOL File: 7389-87-9.mol

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Methyl L-histidinate dihydrochloride Property

Melting point:: 207 °C (dec.)(lit.)
alpha: 9 º (c=2 in H2O)
refractive index: 10 ° (C=2, H2O)
storage temp.: Inert atmosphere,2-8°C
solubility: 100g/l
form: Fine Crystalline Powder
color: White
optical activity: [α]20/D +9.0°, c = 2 in H2O
Water Solubility: Soluble in dimethyl sulfoxide, methanol and water.
Sensitive: Hygroscopic
BRN: 3572010
InChI: InChI=1/C7H11N3O2.2ClH/c1-12-7(11)6(8)2-5-3-9-4-10-5;;/h3-4,6H,2,8H2,1H3,(H,9,10);2*1H/t6-;;/s3
InChIKey: DWAYENIPKPKKMV-ILKKLZGPSA-N
SMILES: C1(N=CNC=1)C[C@H](N)C(=O)OC.Cl.Cl |&1:6,r|
CAS DataBase Reference: 7389-87-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H15403
Product name: L-Histidine methyl ester dihydrochloride
Purity: 97%
Packaging: 25g
Price: $96.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: H15403
Product name: L-Histidine methyl ester dihydrochloride
Purity: 97%
Packaging: 100g
Price: $267
Updated: 2025/07/31

TCI Chemical

Product number: H0977
Product name: L-Histidine Methyl Ester Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: H0977
Product name: L-Histidine Methyl Ester Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $75
Updated: 2025/07/31

Usbiological

Product number: 013214
Product name: L-Histidine Methyl Ester Dihydrochloride
Packaging: 10g
Price: $319
Updated: 2021/12/16

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Methyl L-histidinate dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

L-Histidine methyl ester dihydrochloride is used to prepare optically pure L-(+)-ergothioneine.

Uses

Methyl L-histidinate dihydrochloride is used in the preparation of optically pure L-(+)-Ergothioneine.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

645-35-2

4467-54-3

Example 1; Synthesis of (R)-2-amino-3-(1H-imidazol-4-yl)propanoic acid methyl ester dihydrochloride was carried out by improving the method reported by Cook et al. In a 200 L Schott glass reactor equipped with an air-driven stirrer, a high-efficiency condenser and a gas introduction port, 12.5 kg of L-histidine hydrochloride monohydrate was suspended in 130 L of methanol. Dry HCl gas was passed into the suspension while the mixture was heated to 55-65 °C until complete dissolution. The passage of HCl gas was continued until saturation, at which point it was stopped. Shortly after the solution was formed, a precipitation of the product began to appear. The mixture is stirred continuously and supplemented with additional passes of HCl gas every 1 hour and 15 minutes; the mixture is heated under mild reflux conditions for 8 hours. After the reaction is complete, it can be kept warm for 6-8 hours. Subsequently, 40 L of ethyl acetate is added, stirred for 1 hour and filtered. The filter cake was washed with 10 L of isopropyl ether and the resulting white crystalline product was air dried. The yield was 95%. The melting point was 102-103 °C (literature value 102-103 °C). Spinodal [α]25D = +3.5° (c=2, H2O).1H NMR (D2O) data: δ 3.4 (t, 2H), 3.9 (s, 3H), 4.5 (s, 2H), 7.4 (s, 1H), 8.5 (s, 1H).

References

[1] Tetrahedron Asymmetry, 2008, vol. 19, # 3, p. 273 - 278
[2] Patent: US2009/93642, 2009, A1. Location in patent: Page/Page column 6; 7

Methyl L-histidinate dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl L-histidinate dihydrochloride Suppliers

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View Lastest Price from Methyl L-histidinate dihydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methyl L-histidinate dihydrochloride 7389-87-9
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 98.0%min BR
Supply Ability: 10000G
Release date: 2021-08-23

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-His-OMe.2Hcl 7389-87-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-23

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl L-histidinate dihydrochloride 7389-87-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-08

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-Histidine methyL

Methyl L-histidinate dihydrochloride USP/EP/BP

[(2S)-3-(1H-imidazol-3-ium-4-yl)-1-methoxy-1-oxopropan-2-yl]azanium

Methyl-L-histidinatdihydrochlorid

methyl (2S)-2-amino-3-(1H-imidazol-5-yl)propanoate

L-Histidine, methyl ester, hydrochloride (1:2)

Methyl L-histidinate dihydrochloride, 10 mM in DMSO

<sc>L</sc>-Histidine methyl ester dihydrochloride

7389-87-9

Amino Acid Derivatives

Protected & Labeled Amino Acids

Amino Acid Methyl Esters

Amino Acids (C-Protected)

Peptide Synthesis

Specialty Synthesis

Histidine

ESTER

Histidine [His, H]