5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID
- Product Name
- 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID
- CAS No.
- 10242-10-1
- Chemical Name
- 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID
- Synonyms
- RT 63;ASISCHEM D19360;BUTTPARK 40\07-65;5-Chlorocoumarilic acid;ASINEX-REAG BAS 12719327;5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID;5-Chloro-2-benzofurancarboxylic acid;2-Benzofurancarboxylic acid, 5-chloro-;5-Chlorobenzo[b]furan-2-carboxylic acid;5-Chlorobenzofuran-2-carboxylic Acid >
- CBNumber
- CB1264793
- Molecular Formula
- C9H5ClO3
- Formula Weight
- 196.59
- MOL File
- 10242-10-1.mol
5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID Property
- Melting point:
- 275°C (subl.)
- Boiling point:
- 348.8±22.0 °C(Predicted)
- Density
- 1.502
- storage temp.
- 2-8°C
- form
- powder to crystal
- pka
- 2.94±0.30(Predicted)
- color
- White to Light yellow
- λmax
- 301nm(EtOH)(lit.)
- CAS DataBase Reference
- 10242-10-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29321900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2890
- Product name
- 5-Chlorobenzofuran-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $85
- Updated
- 2025/07/31
- Product number
- C2890
- Product name
- 5-Chlorobenzofuran-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $287
- Updated
- 2024/03/01
- Product number
- C429068
- Product name
- 5-Chlorobenzofuran-2-carboxylic Acid
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC75031
- Product name
- 5-Chloro-1-benzofuran-2-carboxylic acid
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FC75031
- Product name
- 5-Chloro-1-benzofuran-2-carboxylic acid
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
Light red powder
Synthesis
685-87-0
635-93-8
10242-10-1
General procedure for the synthesis of 5-chlorobenzofuran-2-carboxylic acid from diethyl bromomalonate and 5-chlorosalicylaldehyde: 5-chlorosalicylaldehyde (10.62 g, 67.8 mmol), diethyl bromomalonate (25.3 g, 105.8 mmol), and anhydrous potassium carbonate (9.37 g, 67.8 mmol) were suspended in ethylmethyl ketone (50 mL), and the reaction was carried out at reflux. The reaction was carried out for 5 h, followed by stirring at room temperature overnight. Upon completion of the reaction, the solvent was removed by evaporation and the residue was diluted with water (500 mL) and neutralized with 1N HCl solution. The resulting suspension was extracted with ether (Et2O) and the organic phase was dried over anhydrous magnesium sulfate (MgSO4) and concentrated. The oily residue was dissolved in anhydrous ethanol (50 mL) and 10% ethanol solution of potassium hydroxide (KOH) was added. The thick suspension formed was refluxed overnight under vigorous stirring. After cooling to room temperature, the solvent was removed by evaporation and water was added. The aqueous phase was washed with ether (Et2O) and the pH was subsequently adjusted to 2 with 1 N HCl. The aqueous suspension was extracted with ethyl acetate (EtOAc), and the organic phase was dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give pure 5-chlorobenzofuran-2-carboxylic acid (7.4 g, 37.6 mmol, 55.5% yield) as a yellow oil.
References
[1] Patent: US6025390, 2000, A
[2] Gazzetta Chimica Italiana, 1955, vol. 85, p. 381,388
[3] Patent: US4332952, 1982, A
[4] Patent: US4342771, 1982, A
5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID manufacturers
- Product
- 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID 10242-10-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID 10242-10-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23