ChemicalBook > CAS DataBase List > AZD5363
AZD5363
- Product Name
- AZD5363
- CAS No.
- 1143532-39-1
- Chemical Name
- AZD5363
- Synonyms
- Capivasertib;4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-;CS-561;AZD5636;AZD5363;AZD5356;Capivasertinib;AZD5363 USP/EP/BP;AZD-5363; AZD 5363;AZD5363(Capivasertib)
- CBNumber
- CB12650349
- Molecular Formula
- C21H25ClN6O2
- Formula Weight
- 428.92
- MOL File
- 1143532-39-1.mol
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AZD5363 Property
- Melting point:
- 161-164°C
- Density
- 1.381
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 13.93±0.50(Predicted)
- form
- Solid
- color
- Off-White to Pale Beige
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 15406
- Product name
- AZD 5363
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15406
- Product name
- AZD 5363
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $166
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15406
- Product name
- AZD 5363
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $231
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15406
- Product name
- AZD 5363
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $412
- Updated
- 2024/03/01
Tocris
- Product number
- 6978
- Product name
- AZD5363
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $545
- Updated
- 2021/12/16
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AZD5363 Chemical Properties,Usage,Production
Uses
AZD5363 is used in inhibiting the proliferation of certain tumor cell lines.
Biological Activity
azd5363 is a novel, potent phosphoinositide 3-kinase (pi3k)/akt pathway inhibitor with ic50 value of ~200nm. [1]azd5363 is proved to inhibit castrate resistant prostate cancer (crpc) progression. clusterin (clu) and autophagy will be induced which may work as cytoprotective responses which can affect the downstream pi3k/akt signaling. [2] azd5363 inhibits the growth of a lot of human tumor cells in a dose dependent manner. the mode of action could be monotherapy as well as in combination with her2 inhibitors in breast cancer models. [3] it is suggested to induce cell apoptosis by measuring the expression of parp cleavage, the activity of caspase 3, et al. [1]most importantly, azd5363 can target the pi3k/akt-pathway in vivo significantly, thus reducing the serum psa-levels and tumor volume, finally, it could postpone the progression to crpc.[1]
target
Akt
storage
Store at -20°C
References
[1] thomas c, crafter c, davies b, zoubeidi a, gleave me. azd5363, a novel akt inhibitor, delays prostate cancer progression. the journal of urology. may 2011. 185(4s): e292-293.
[2] kumano m, zhang f, shiota m, crafter c, davies b, zoubeidi a, gleave m. clusterin knockdown enhances antitumor activity of a novel akt inhibitor, azd5363, through inhibition of autophagy in prostate cancer. the journal of urology. may 21 2012. e392.
[3] davies br, greenwood h, dudley p, et al. preclinical pharmacology of azd5363, an inhibitor of akt: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. mol. cancer ther. arp 2012. 11: 873.
AZD5363 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AZD5363 manufacturers
Apeloa production Co.,Limited
- Product
- Capivasertib (AZD5363) 1143532-39-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 11000
- Release date
- 2024-06-17
Career Henan Chemical Co
- Product
- AZD5363 1143532-39-1
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24
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